<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032024000400302</article-id>
<article-id pub-id-type="doi">10.35366/117520</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome poliendocrino autoinmune tipo 2: la importancia de la sospecha clínica y el diagnóstico oportuno. Revisión de literatura y reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Autoimmune polyendocrine autoimmune syndrome type 2: the importance of clinical suspicion and timely diagnosis. Literature review and a case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales Muñoz]]></surname>
<given-names><![CDATA[Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Pérez]]></surname>
<given-names><![CDATA[María José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Weber]]></surname>
<given-names><![CDATA[Federico Leopoldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad La Salle Hospital Angeles Pedregal Facultad Mexicana de Medicina]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad La Salle Hospital Angeles Pedregal Facultad Mexicana de Medicina]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad La Salle Hospital Angeles Pedregal Facultad Mexicana de Medicina]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>302</fpage>
<lpage>306</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032024000400302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032024000400302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032024000400302&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los síndromes poliendocrinos autoinmunes (SPA) son una condición rara que incluye un grupo de manifestaciones derivadas de la pérdida de la tolerancia inmune en glándulas endocrinas, pudiendo también afectar órganos no endocrinos. En la actualidad, pueden estar divididos en formas monogénicas raras como el síndrome poliendocrino autoinmune tipo 1 (SPA1) y una variante poligénica más frecuente que es el tipo 2 (SPA2) o síndrome de Schmidt. Se presentan en la infancia o edad adulta y se caracterizan por la presencia de autoanticuerpos circulantes e infiltración linfocítica de tejidos u órganos que causan falla orgánica. Las manifestaciones clínicas son variadas y el retraso en el diagnóstico es frecuente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Autoimmune polyendocrine syndromes (APS) are a rare condition that includes a group of manifestations derived from the loss of immune tolerance in endocrine glands and can also affect non-endocrine organs. Currently, they can be divided into rare monogenic forms, such as autoimmune polyendocrine syndrome type 1 (APS1) and a more common polygenic variant, type 2 (APS2) or Schmidt syndrome. They occur in childhood or adulthood and are characterized by circulating autoantibodies and lymphocytic infiltration of tissues or organs that cause organ failure. The clinical manifestations are varied, and delays in diagnosis are common.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Schmidt]]></kwd>
<kwd lng="es"><![CDATA[poliglandular]]></kwd>
<kwd lng="es"><![CDATA[poliendocrino]]></kwd>
<kwd lng="es"><![CDATA[hipotiroidismo]]></kwd>
<kwd lng="es"><![CDATA[insuficiencia adrenal]]></kwd>
<kwd lng="en"><![CDATA[Schmidt]]></kwd>
<kwd lng="en"><![CDATA[polyglandular]]></kwd>
<kwd lng="en"><![CDATA[polyendocrine]]></kwd>
<kwd lng="en"><![CDATA[hypothyroidism]]></kwd>
<kwd lng="en"><![CDATA[adrenal insufficiency]]></kwd>
</kwd-group>
</article-meta>
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