<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032024000300190</article-id>
<article-id pub-id-type="doi">10.35366/116823</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectividad de la toxina botulínica tipo A en el manejo de fisuras anales crónicas resistentes a manejo conservador en una práctica privada en la Ciudad de México]]></article-title>
<article-title xml:lang="en"><![CDATA[Effectiveness of botulinum toxin type A in the management of chronic anal fissures resistant to conservative therapy in a private practice in Mexico City]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Telich Tarriba]]></surname>
<given-names><![CDATA[José E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Tello]]></surname>
<given-names><![CDATA[Itzel V]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Telich Vidal]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villanueva Saenz]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles Pedregal Departamento de Cirugía Plástica y Reconstructiva ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Traumatología, Ortopedia y Rehabilitación &#8220;Dr. Victorio de la Fuente Narváez&#8221; Departamento de Cirugía Plástica y Reconstructiva ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Ángeles Pedregal Departamento de Cirugía de Colon y Recto ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<volume>22</volume>
<numero>3</numero>
<fpage>190</fpage>
<lpage>193</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032024000300190&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032024000300190&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032024000300190&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La fisura anal crónica es un desgarro del anodermo. Aunque la cirugía es el estándar de oro, sus efectos a largo plazo aún generan preocupación. El mecanismo de acción de la toxina botulínica ha alentado su uso como una forma de tratamiento mínimamente invasiva. El objetivo de este estudio es demostrar la efectividad de la toxina botulínica tipo A para el tratamiento de las fisuras anales en un grupo de pacientes de la Ciudad de México.  Material y métodos:  Estudio en el que se incluyeron 15 pacientes con diagnóstico de fisuras anales refractarias a manejo conservador. A cada paciente se le aplicaron 16 UI de toxina botulínica distribuidas en dos sitios de punción. Posteriormente fueron evaluados en la consulta externa durante un periodo de dos meses.  Resultados:  Se incluyeron 15 pacientes, siete hombres (46%) y ocho mujeres (53%) con una mediana de edad de 39 años (rango 22 a 72), 12 pacientes (80%) presentaron resolución total del cuadro. El resto de los pacientes fueron sometidos a procedimientos quirúrgicos debido a la falla en el tratamiento.  Conclusiones:  La aplicación de toxina botulínica es un método viable para el manejo de la FAC, logrando mejoría hasta en 80% de los casos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Chronic anal fissure is a linear split of the anoderm. Although surgery is the gold standard treatment, its side effects raise concerns. Recent studies have suggested encouraging results for the role of botulinum toxin in the treatment of anal fissures. This study aims to demonstrate the effectiveness of botulinum toxin type A for the treatment of anal fissures.  Material and methods:  Fifteen patients with a diagnosis of anal fissures refractory to conservative management were included. 16 IU of toxin was applied to each patient and distributed in two sites on the 3 and 9 o&#8217;clock axes. They were subsequently evaluated in the outpatient clinic over two months.  Results:  15 patients were treated, seven men (46%) and eight women (53%), with a median age of 39 years (range 22 to 72). Twelve patients (80%) presented a complete resolution of the condition. The rest of the patients underwent surgical procedures due to treatment failure.  Conclusions:  BT injection has been an accepted method for the management of CAF. This study demonstrates a cure rate of 80% with a 16 IU dose of botulinum toxin distributed along the 3 and 9 o&#8217;clock axes in the anal canal.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[toxina botulínica tipo A]]></kwd>
<kwd lng="es"><![CDATA[fisura anal]]></kwd>
<kwd lng="es"><![CDATA[conducto anal]]></kwd>
<kwd lng="es"><![CDATA[tratamiento conservador]]></kwd>
<kwd lng="es"><![CDATA[enfermedades anales]]></kwd>
<kwd lng="es"><![CDATA[México]]></kwd>
<kwd lng="en"><![CDATA[botulinum toxins type A]]></kwd>
<kwd lng="en"><![CDATA[fissure in anus]]></kwd>
<kwd lng="en"><![CDATA[anal canal]]></kwd>
<kwd lng="en"><![CDATA[conservative treatment]]></kwd>
<kwd lng="en"><![CDATA[anus diseases]]></kwd>
<kwd lng="en"><![CDATA[Mexico]]></kwd>
</kwd-group>
</article-meta>
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