<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032019000400380</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de deleción 22q11.2 en adulto femenino: síndrome de DiGeorge]]></article-title>
<article-title xml:lang="en"><![CDATA[22q11.2 deletion syndrome in adult woman: DiGeorge syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez Carrillo]]></surname>
<given-names><![CDATA[Luis Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Lezama]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Armenta Flores]]></surname>
<given-names><![CDATA[Rómulo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles León División de Medicina ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Ángeles León Departamento de Ecocardiografía ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Médica Campestre División de Cirugía ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>17</volume>
<numero>4</numero>
<fpage>380</fpage>
<lpage>384</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032019000400380&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032019000400380&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032019000400380&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  El síndrome de deleción 22q11.2 es una anomalía cromosómica que origina un cuadro clínico caracterizado por malformaciones congénitas que incluyen defectos cardiacos y endocrinos asociados a anomalías del paladar, dismorfismo facial e inmunodeficiencia.  Caso clínico:  Femenino de 40 años con estenosis aórtica congénita, la cual presenta infecciones faríngeas frecuentes. Se establecieron los diagnósticos de hipoparatiroidismo, hipotiroidismo subclínico asociado con anomalías leves craneofaciales. Se confirmó síndrome de deleción 22q11.2, siendo el principal problema a resolver estenosis aórtica severa a pesar de encontrarse asintomática desde el punto de vista cardiovascular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  The 22q11.2 deletion syndrome is a chromosomal anomaly that causes a clinical picture characterized by congenital malformations that include cardiac and endocrine defects, associated with abnormalities of the palate, facial dysmorphism and immunodeficiency.  Case report:  A 40-year-old female with congenital aortic stenosis, who presents frequent pharyngeal infections, in which the diagnoses of hypoparathyroidism, subclinical hypothyroidism associated with mild craniofacial anomalies were established, corresponding to 22q11.2 deletion syndrome that was confirmed. Her main problem to solve is the severe aortic stenosis despite being asymptomatic from the cardiovascular point of view.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de deleción 22q11.2]]></kwd>
<kwd lng="es"><![CDATA[estenosis congénita de la válvula aórtica]]></kwd>
<kwd lng="en"><![CDATA[22q11.2 deletion syndrome]]></kwd>
<kwd lng="en"><![CDATA[congenital aortic stenosis valvulopathy]]></kwd>
</kwd-group>
</article-meta>
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