<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032019000300274</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Signo de Leser-Trélat, como manifestación inicial en adenocarcinoma gástrico oculto]]></article-title>
<article-title xml:lang="en"><![CDATA[Leser-Trélat sign, as an initial manifestation in hidden gastric adenocarcinoma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Palomar]]></surname>
<given-names><![CDATA[Francisco José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Boyer Duck]]></surname>
<given-names><![CDATA[Estefanía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas Chandomid]]></surname>
<given-names><![CDATA[Estefanía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar Arriaga]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montes de Oca Orellana]]></surname>
<given-names><![CDATA[Claudio Rene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alfeirán Ruiz]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles Pedregal  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Dermatológico &#8220;Dr. Ladislao de la Pascua&#8221;  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Ángeles Pedregal  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Ángeles Pedregal  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>17</volume>
<numero>3</numero>
<fpage>274</fpage>
<lpage>277</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032019000300274&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032019000300274&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032019000300274&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El signo de Leser-Trélat es un síndrome paraneoplásico cutáneo, es una dermatosis explosiva (queratosis seborreica) asociada con malignidad oculta. Paciente masculino de 67 años, inició con dispepsia, aerofagia y reflujo, pérdida de peso. La exploración revela neoformaciones queratósicas en tórax y abdomen, pigmentadas café. En la endoscopia se encontró con adenocarcinoma gástrico. PET/CT metástasis hepáticas. Se realizó esofagogastrectomía con anastomosis esófago-gástrica. La fisiopatología se presume por factores de crecimiento producidos por el tumor. La sobrevida depende del tipo y estadio del tumor primario. Ante la aparición de este signo se recomienda la búsqueda intencionada de neoplasia oculta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The sign of Leser-Trélat is a cutaneous paraneoplastic syndrome; it is an explosive dermatosis (seborrheic keratosis) associated with occult malignancy. Male 67, started with dyspepsia, aerophagia and reflux, weight loss. Physical examination with brown keratotic neoformations, in thorax and abdomen. In the endoscopy was found a gastric adenocarcinoma. PET/CT with liver metastases. Esophagogastrectomy was performed with esophagogastric anastomosis. The pathophysiology is presumed by growth factors produced by the tumor. Survival depends on the type and stage of the primary tumor. When this sign is found, the intentional search for occult neoplasia is recommended.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome paraneoplásico]]></kwd>
<kwd lng="es"><![CDATA[cáncer gástrico]]></kwd>
<kwd lng="es"><![CDATA[queratosis seborreica]]></kwd>
<kwd lng="es"><![CDATA[signo de Leser-Trélat]]></kwd>
<kwd lng="en"><![CDATA[Paraneoplastic syndromes]]></kwd>
<kwd lng="en"><![CDATA[gastric cancer]]></kwd>
<kwd lng="en"><![CDATA[seborrheic keratosis]]></kwd>
<kwd lng="en"><![CDATA[Leser-Trélat sign]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Safa]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Darrieux]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leser-Trélat sign without internal malignancy]]></article-title>
<source><![CDATA[Case Rep Oncol]]></source>
<year>2011</year>
<volume>4</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>175-7</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Turan]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Yesilova]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Yurt]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Koçarslan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leser-Trélat sign: does it really exist?]]></article-title>
<source><![CDATA[Acta Dermatovenerol Croat]]></source>
<year>2013</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>123-7</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Venegas]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Vaccaro]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Abudinén]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Reydet]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Brunie]]></surname>
<given-names><![CDATA[VF]]></given-names>
</name>
<name>
<surname><![CDATA[Arcuch]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Signo de Leser-Trélat asociado a adenocarcinoma gástrico: Caso clínico]]></article-title>
<source><![CDATA[Rev Méd Chile]]></source>
<year>2012</year>
<volume>140</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1585-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ponti]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Luppi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Losi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Giannetti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Seidenari]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers]]></article-title>
<source><![CDATA[J Hematol Oncol]]></source>
<year>2010</year>
<volume>3</volume>
<page-range>2</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dasanu]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Alexandrescu]]></surname>
<given-names><![CDATA[DT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung]]></article-title>
<source><![CDATA[South Med J]]></source>
<year>2009</year>
<volume>102</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>216-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[XH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leser-Trelat sign with primary hepatic carcinoma]]></article-title>
<source><![CDATA[Indian J Dermatol Venereol Leprol]]></source>
<year>2015</year>
<volume>81</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>320-1</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blázquez]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández-López]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández-Canedo]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[de Unamuno]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Martín-Pascual]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Signo de Leser-Trélat asociado a síndrome de Sézary]]></article-title>
<source><![CDATA[Actas Dermosifiliogr]]></source>
<year>2009</year>
<volume>94</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>309-12</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nyati]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kalwaniya]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Jain]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Soni]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sign of Leser-Trélat in association with laryngeal carcinoma]]></article-title>
<source><![CDATA[Indian J Dermatol Venereol Leprol]]></source>
<year>2016</year>
<volume>82</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>112</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sperry]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Wall]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adenocarcinoma of the stomach with eruptive seborrheic keratoses: the sign of Leserp-Trélat]]></article-title>
<source><![CDATA[Cancer]]></source>
<year>1980</year>
<volume>45</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2434-7</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mittal]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[Sonal]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The sign of Leser-Trelat.]]></article-title>
<source><![CDATA[Indian J Dermatol Venereol Leprol]]></source>
<year>2001</year>
<volume>67</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>177</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Mesquita Kde]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Igreja]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Lucas]]></surname>
<given-names><![CDATA[IC]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Paraneoplastic cutaneous manifestations: concepts and updates]]></article-title>
<source><![CDATA[An Bras Dermatol]]></source>
<year>2013</year>
<volume>88</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>9-22</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stollmeier]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rosario]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Mayer]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
<name>
<surname><![CDATA[Frandoloso]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
<name>
<surname><![CDATA[Marques]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Seborrheic keratoses as the first sign of bladder carcinoma: case report of Leser-Trélat sign in a rare association with urinary tract cancer]]></article-title>
<source><![CDATA[Case Rep Med]]></source>
<year>2016</year>
<numero>2016</numero>
<issue>2016</issue>
<page-range>4259190</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tajima]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mitsuoka]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ohtsuka]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Nakayama]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Satoh]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case of hepatocellular carcinoma with the sign of Leser-Trelat: a possible role of a cutaneous marker for internal malignancy]]></article-title>
<source><![CDATA[Jpn J Med]]></source>
<year>1991</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>53-6</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Patton]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Zirwas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nieland-Fisher]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Jukic]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inflammation of seborrheic keratoses caused by cytarabine: a pseudo sign of Leser-Trelat]]></article-title>
<source><![CDATA[J Drugs Dermatol]]></source>
<year>2004</year>
<volume>3</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>565-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
