<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032019000300259</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de X frágil]]></article-title>
<article-title xml:lang="en"><![CDATA[Fragile X syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarro Vidaurri]]></surname>
<given-names><![CDATA[Germán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez Carrillo]]></surname>
<given-names><![CDATA[Luis Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles León División de Pediatría ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Guanajuato Facultad de Medicina de León ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>17</volume>
<numero>3</numero>
<fpage>259</fpage>
<lpage>262</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032019000300259&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032019000300259&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032019000300259&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  El síndrome del X frágil (SXF) es un trastorno hereditario ligado al cromosoma X que afecta sobre todo a hombres y ocasiona de forma principal discapacidad intelectual; la etiología es una mutación por expansión de tripletes de nucleótidos CGG en el gen FMR1 localizado en la región Xq27.3.  Caso clínico:  Preescolar de seis años con retraso psicomotor, caracterizado por lenguaje y funciones cognitivas correspondientes a dos años de edad; con características fenotípicas compatibles con SXF, cuyo cariotipo demostró presencia de mosaicismo para 46,Y fra(X) (q27.3), con problemas asociados de infección de vías aéreas superiores secundarias a reflujo gastroesofágico.  Conclusiones:  El síndrome de X frágil representa la causa más común de retraso mental hereditario, discapacidad intelectual y autismo, además de ser la segunda causa más común de deficiencias mentales asociadas genéticamente, después de la trisomía 21.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Fragile X syndrome is an inherited disease linked to the X chromosome that mainly affects men and that causes principally intellectual disability; its etiology is a mutation by expansion of CGG trinucleotide repeats in the FMR1 gene located at region Xq27.3.  Case report:  Preschool of six years old with psychomotor delay, characterized by language and cognitive functions corresponding to two years of age; with phenotypic characteristics compatible with SXF, whose karyotype showed presence of mosaicism for 46, and fra (X) (q27.3), with associated problems of upper airways infection secondary to gastroesophageal reflux.  Conclusions:  Fragile X syndrome represents the most common cause of hereditary mental retardation, intellectual disability and autism, being the second most common cause of mental deficiencies genetically associated, after trisomy 21.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome del cromosoma X frágil]]></kwd>
<kwd lng="es"><![CDATA[discapacidad intelectual]]></kwd>
<kwd lng="es"><![CDATA[retraso mental hereditario]]></kwd>
<kwd lng="en"><![CDATA[Fragile X syndrome]]></kwd>
<kwd lng="en"><![CDATA[intellectual disability]]></kwd>
<kwd lng="en"><![CDATA[inherited mental retardation]]></kwd>
</kwd-group>
</article-meta>
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