<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-249X</journal-id>
<journal-title><![CDATA[Journal of the Mexican Chemical Society]]></journal-title>
<abbrev-journal-title><![CDATA[J. Mex. Chem. Soc]]></abbrev-journal-title>
<issn>1870-249X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Química de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-249X2025000300531</article-id>
<article-id pub-id-type="doi">10.29356/jmcs.v69i3.2330</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Evaluation of the Apparent Permeability Xoefficient (Papp) of 5-o-&#946;-d galactopyranosyl-7-methoxy-3'-4'-dihydroxy-4-phenylcoumarin in MDCK Cells]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vara-Gama]]></surname>
<given-names><![CDATA[Nancy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rubio-Carrasco]]></surname>
<given-names><![CDATA[Kenneth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Covarrubias]]></surname>
<given-names><![CDATA[Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Niizawa]]></surname>
<given-names><![CDATA[Sol Cristians]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fuentes Noriega]]></surname>
<given-names><![CDATA[Ines]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Faculty of Chemistry Department of Pharmacy]]></institution>
<addr-line><![CDATA[ CDMX]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,National Institute of Genomic Medicine  ]]></institution>
<addr-line><![CDATA[ CDMX]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México Biology Institute ]]></institution>
<addr-line><![CDATA[ CDMX]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>69</volume>
<numero>3</numero>
<fpage>531</fpage>
<lpage>541</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-249X2025000300531&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-249X2025000300531&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-249X2025000300531&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Diabetes mellitus is a common chronic degenerative disease around the world. With the Encuesta Nacional de Salud y Nutrición (ENSANUT or National Health and Nutrition Survey) ranking the disease among the highest in terms of morbidity in Mexico[1], allied to the increase in metabolic syndrome worldwide, the development of new medicines for the treatment of diabetes mellitus is essential. Among these medicines is 5-O-&#946;-D-galactopyranosyl-7-methoxy-3&#8217;-4&#8217;-dihydroxy-4-phenylcoumarin, an organic compound isolated from the leaves of Hintonia latiflora, also known as copalchi [2,3]. An effective preclinical assessment of a drug candidate molecule requires various preclinical tests, including the measurement of apparent permeability in in vitro models. [4-7] Using HPLC-UV, an analytical method was developed and then validated by means of both the FDA validation guidelines for bioanalytical methods (2001) and NOM-177-SSA1-2013 [8,9], with the method found to be reproducible, sensitive, and selective for the determination of 5-O-&#946;-D-galactopyranosyl-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin, which is a phytodrug (4-FC) corresponding to the Madin-Darby canine kidney (MDCK) cell line. The cytotoxicity of the phytodrug was determined for concentrations ranging from 0.1 to 100 &#956;g/mL, [10] using cis-platinum as a positive control (0.01 to 10 &#956;g /mL). The results obtained showed a non-significant cytotoxic effect in a range of 0.10 to 100 µg/mL, while, at concentrations of 4, 8 and, 16 &#956;g/mL, the phytodrug presented a permeation rate (dQ/dt) higher than ranitidine hydrochloride (Ran) and lower than propranolol hydrochloride (Pro), thus suggesting a moderate permeation rate. The present study developed and validated a method for quantifying the analyte of interest, with cytotoxicity (IC50) and permeability tests also carried out in MDCK cells.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La diabetes mellitus es una enfermedad crónico degenerativa común a nivel mundial. En México, la ENSANUT reporta que dicha enfermedad ocupa primeros lugares de morbilidad. [1] El aumento del síndrome metabólico a nivel mundial, hace indispensable el desarrollo de nuevos medicamentos para tratar la diabetes mellitus, tal es el caso de la 5-O -&#946;-D-galactopiranosil-7-metoxi-3&#8217;-4&#8217;-dihidroxi-4-fenilcumarina; un compuesto orgánico aislado de las hojas de Hintonia latiflora conocida como &#8220;Copalchi&#8221; [2,3]. Para una adecuada evaluación a nivel preclínico de moléculas candidatas a fármaco es necesario realizar diversas pruebas a nivel preclínico, entre ellas la permeabilidad aparente en modelos in vitro. [4-7] Se desarrollo y se realizó la validación de un método analítico por HPLC-UV, considerando las guías de validación de Métodos Bioanalíticos por la FDA (2001) y la NOM-177-SSA1-2013. [8,9], el mmétodo resultóser reproducible, sensible y selectivo para la determinación de la 5-O- &#946;-D-galactopiranosil-7-metoxi-3',4'-dihidroxi-4-fenilcumarina un fitofármaco (4-FC) en la línea celular epitelio de riñón canino Madin-Darby (MDCK). Se determinó la citotoxicidad del fitofármaco en un rango de concentraciones de 0.1 a 100 &#956;g/mL, [10] utilizando cis-platino como control positivo (0.01 a 10 &#956;g/mL). Los resultados mostraron un efecto citotóxico no significativo en un rango de 0.10 a 100 µg/mL del fitofármaco a las concentraciones 4, 8 y 16 &#956;g/mL, presentó una velocidad de permeación (dQ/dt) mayor que el clorhidrato de ranitidina (Ran) y menor que el clorhidrato de propranolol (Pro); lo que sugiere una velocidad de permeación moderada para dicho fitofármaco. En este trabajo se desarrollo, se validó el método para la cuantificación del analito de interés, se hizo el estudio de citotoxicidad (IC50) y el estudio de permeabilidad en células MDCK.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cytotoxicity]]></kwd>
<kwd lng="en"><![CDATA[permeability]]></kwd>
<kwd lng="en"><![CDATA[5-o-&#946;-d galactopyranosyl-7-methoxy-3'-4'-dihydroxy-4-phenylcoumarin]]></kwd>
<kwd lng="en"><![CDATA[MDCK]]></kwd>
<kwd lng="en"><![CDATA[Hintonia latiflora]]></kwd>
<kwd lng="es"><![CDATA[Citotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[permeabilidad]]></kwd>
<kwd lng="es"><![CDATA[5-o-&#946;-d galactopyranosil-7-metoxi-3'-4'-dihidroxi-4-fenilcumarina]]></kwd>
<kwd lng="es"><![CDATA[células MDCK]]></kwd>
<kwd lng="es"><![CDATA[Hintonia latiflora]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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