<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-249X</journal-id>
<journal-title><![CDATA[Journal of the Mexican Chemical Society]]></journal-title>
<abbrev-journal-title><![CDATA[J. Mex. Chem. Soc]]></abbrev-journal-title>
<issn>1870-249X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Química de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-249X2019000400115</article-id>
<article-id pub-id-type="doi">10.29356/jmcs.v63i4.729</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Cytotoxic and Antitumoral Effects of Bikaverin Isolated from Gibberella fujikuroi on L5178Y Lymphoma Murine Model]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hinojosa-Ventura]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Puebla-Pérez]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallegos-Arreola]]></surname>
<given-names><![CDATA[Martha Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chávez-Parga]]></surname>
<given-names><![CDATA[Ma. del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Estrada]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado-Saucedo]]></surname>
<given-names><![CDATA[Jorge Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guadalajara Centro Universitario de Ciencias Exactas e Ingenierías Departamento de Farmacobiología]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,I.M.S.S. Centro de Investigación Biomédica de Occidente ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Michoacana de San Nicolás de Hidalgo Departamento de Ingeniería Química ]]></institution>
<addr-line><![CDATA[Morelia Michoacán]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma del Estado de Morelos Centro de Investigaciones Químicas ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>63</volume>
<numero>4</numero>
<fpage>115</fpage>
<lpage>122</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-249X2019000400115&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-249X2019000400115&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-249X2019000400115&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract. In this work, bikaverin was isolated from the mycelium of Gibberella fujikuroi and characterized using 1D (1H and 13C) and 2D (HSQC and HMBC) NMR spectroscopy. Its cytotoxic effect on L5178Y lymphoma cells and antitumor effect on BALB/c mice inoculated with L5178Y cells were evaluated. According to the results, bikaverin showed cytotoxic effect against L5178Y lymphoma cells with an IC50 value of 0.23 &#956;g/mL.The tumor evolution, with and without treatment, was observed in the in vivo study; the group without treatment showed 1,280±128 x 105 cells/mL in ascites volume, and the groups treated with bikaverin at the dose of 1.73 mg/kg/day by intraperitoneal (i.p.) and oral administration, decreased significantly the cell density, and showed 391.5±237 x 105 cells/mL and 580±208 x 105 cells/mL, respectively. The results confirm the cytotoxic effect of bikaverin on cancer cell lines and contribute to show the potential of bikaverin as antitumoral compound in BALB/c mice inoculated with L5178Y lymphoma cells.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen. En este trabajo, se reporta el aislamiento de bikaverina a partir del micelio de Gibberella fujikuroi, cuya estructura fue elucidada mediante el uso de la espectroscopia de RMN en 1D (1H y 13C) y 2D (HSQC y HMBC). Se evaluó su efecto citotóxico en células de linfoma L5178Y y su efecto antitumoral en ratones BALB/c inoculados con células L5178Y. De acuerdo con los resultados, la bikaverina mostró efecto citotóxico contra las células de linfoma L5178Y con un valor de CI50 de 0.23 &#956;g/mL. En el estudio in vivo se observó la evolución del tumor, con y sin tratamiento, donde el grupo sin tratamiento mostró 1,280±128 x 105 células/mL en el volumen de ascitis, y los grupos tratados con bikaverina a la dosis de 1.73 mg/kg/día, administrada de forma intraperitoneal (i.p.) y oral disminuyeron significativamente la densidad celular, mostrando 391.5±237 x 105 células/mL y 580±208 x 105 células/mL, respectivamente. Los resultados obtenidos confirman el efecto citotóxico de bikaverina sobre líneas celulares de cáncer y contribuyen a mostrar su potencial como compuesto antitumoral en ratones BALB/c inoculados con células de linfoma L5178Y.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Gibberella fujikuroi]]></kwd>
<kwd lng="en"><![CDATA[bikaverin]]></kwd>
<kwd lng="en"><![CDATA[polyketide]]></kwd>
<kwd lng="en"><![CDATA[cytotoxic and antitumoral effects]]></kwd>
<kwd lng="es"><![CDATA[Gibberella fujikuroi]]></kwd>
<kwd lng="es"><![CDATA[bikaverina]]></kwd>
<kwd lng="es"><![CDATA[policétido]]></kwd>
<kwd lng="es"><![CDATA[efecto citotóxico y antitumoral]]></kwd>
</kwd-group>
</article-meta>
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