<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-249X</journal-id>
<journal-title><![CDATA[Journal of the Mexican Chemical Society]]></journal-title>
<abbrev-journal-title><![CDATA[J. Mex. Chem. Soc]]></abbrev-journal-title>
<issn>1870-249X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Química de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-249X2018000400214</article-id>
<article-id pub-id-type="doi">10.29356/jmcs.v62i4.624</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Antiproliferative and Anti-inflammatory Acyl Glucosyl Flavones from the Leaves of Bursera copallifera]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Columba-Palomares]]></surname>
<given-names><![CDATA[María C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villarreal]]></surname>
<given-names><![CDATA[María Luisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marquina]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Estrada]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-López]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zamilpa Alvarez]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarez]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma del Estado de Morelos Facultad de Farmacia ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma del Estado de Morelos Centro de Investigación en Biotecnología ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma del Estado de Morelos Centro de Investigaciones Químicas ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,IMSS Centro de Investigación Biomédica del Sur ]]></institution>
<addr-line><![CDATA[ Morelos]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>62</volume>
<numero>4</numero>
<fpage>214</fpage>
<lpage>224</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-249X2018000400214&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-249X2018000400214&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-249X2018000400214&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract. Bursera copallifera (DC) Bullock (Burseraceae) is a plant species used in folk medicine for the treatment of inflammation (bronchitis, cough). The dichloromethane-methanol extract (DML) of B. copallifera leaves was found to possess important antiproliferative and anti-inflammatory activities. In order to further correlate these activities with the phytochemical components, the bioactivity-guided fractionation of the DML extract allowed the isolation of an active fraction which was constituted of five compounds characterized as luteolin-3(-O-(3((-O-E-p-coumaroyl)-&#945;-L-rhamnopyranoside (1), luteolin-3(-O-(2((-O-E-p-coumaroyl)-&#945;-L-rhamnopyranoside (2), (-amyrin (3), 3-epilupeol (4) and stigmasterol (5). Among the five isolated constituents, the triterpenes 3 and 4, and the sterol 5 have been already well known for their anti-inflammatory properties. Flavone 2 (Luteolin-3(-O-(2((-O-E-p-coumaroyl)-&#945;-L-rhamnopyranoside) was responsible for the antiproliferative activity, showing in vitro cytotoxic activity against MCF-7 human cancer cell line with IC50 value of 13.9 µM. On the other hand flavone (1) exhibited COX-1 inhibition (IC50 = 93 (M). Flavone 1, together with the triterpenes 3 and 4 were the responsible for inhibiting TPA-induced inflammation by inhibiting COX-1 enzyme. Therefore, these results support the traditional use of the infusion made with the leaves of B. copallifera as an anti-inflammatory agent.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen. Bursera copallifera es una planta usada en la medicina tradicional para el tratamiento de la inflamación (bronquitis, tos). Se encontró que el extracto de diclorometano-metanol (DML) obtenido de las hojas de B. copallifera posee importante actividad antiproliferativa y antiinflamatoria. Con el objetivo de correlacionar estas actividades con los componentes químicos, se llevó a cabo el fraccionamiento bio-dirigido del extracto DML, el cual permitió el aislamiento de una fracción activa, la cual estaba constituida de cinco compuestos caracterizados como luteolina-3(-O-(3((-O-E-p-coumaroil)-&#945;-L-ramnopiranósido (1), luteolina-3(-O-(2((-O-E-p-coumaroil)-&#945;-L-ramnopiranósido (2), &#945;-amirina (3), 3-epilupeol (4), y estigmasterol (5). De los cinco constituyentes aislados, se conoce a los triterpenos 3 y 4, y el esterol 5, por sus propiedades antiinflamatorias. La flavona 2 (Luteolina-3(-O-(2((-O-E-p-coumaroil)-&#945;-L-ramnopiranósido) fue responsable de la actividad antiproliferativa, mostrando actividad citotóxica in vitro contra la línea celular humana MCF-7 con un valor de CI50 de 13.9 (M. Por otro lado, la flavona 1, junto con los triterpenos 3 y 4, fueron los responsables de inhibir la inflamación inducida por TPA mediante la inhibición de la enzima COX-1. Estos resultados confirman el uso tradicional de la infusión hecha con las hojas de B. copallifera como un agente antiinflamatorio.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Bursera copallifera]]></kwd>
<kwd lng="en"><![CDATA[Burseraceae]]></kwd>
<kwd lng="en"><![CDATA[anti-inflammatory activity]]></kwd>
<kwd lng="en"><![CDATA[antiproliferative activity]]></kwd>
<kwd lng="en"><![CDATA[acyl glucosyl flavones]]></kwd>
<kwd lng="es"><![CDATA[Bursera copallifera]]></kwd>
<kwd lng="es"><![CDATA[Burseraceae]]></kwd>
<kwd lng="es"><![CDATA[actividad antiinflamatoria]]></kwd>
<kwd lng="es"><![CDATA[actividad antiproliferativa]]></kwd>
<kwd lng="es"><![CDATA[acil glucosil flavonas]]></kwd>
</kwd-group>
</article-meta>
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