<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-249X</journal-id>
<journal-title><![CDATA[Journal of the Mexican Chemical Society]]></journal-title>
<abbrev-journal-title><![CDATA[J. Mex. Chem. Soc]]></abbrev-journal-title>
<issn>1870-249X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Química de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-249X2016000400188</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Development and ICH Validation of a RP-HPLC-UV Method for the Quantification of Thimerosal in Topic Creams]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Caballero]]></surname>
<given-names><![CDATA[Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muro-Hidalgo]]></surname>
<given-names><![CDATA[Nancy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-Hipólito]]></surname>
<given-names><![CDATA[Elvia Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villaseñor]]></surname>
<given-names><![CDATA[Alma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Arellano]]></surname>
<given-names><![CDATA[Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Estudios Superiores Cuautitlán Unidad de Investigación Multidisciplinaria]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>60</volume>
<numero>4</numero>
<fpage>188</fpage>
<lpage>193</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-249X2016000400188&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-249X2016000400188&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-249X2016000400188&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: A reversed phase high-performance liquid chromatography (RP-HPLC) method for determination of Thimerosal (TMS) in topical creams was optimized and validated according to the ICH guidelines which include accuracy, precision, selectivity, robustness, limit of detection (LOD), limit of quantification (LOQ), linearity and range. For topical creams, sample treatment is often an overwhelming step essentially due to its oily nature. For the first time a simple and robust extraction procedure for TMS using phosphate buffer (pH 5.5, 0.2M) was successfully developed. This method describes the TMS quantitation by HPLC in a topical product containing 0.01% fluocinolone acetonide (FLA) as the active molecule. The HPLC separation was achieved on a Column Symmetry® and a methanol: phosphate buffer (pH 2.5, 0.05M) 70:30 v/v mobile phase and wavelength 218 nm. Results from both standards and samples showed adequate validation parameters. Noteworthy, linearity was within the range 1.2 - 2.8 µg/ mL. Additionally, robustness and TMS stability were established after sample extraction. The method provides an efficient and safe quality control tool for determination of TMS in topical creams.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Se optimizó y validó un método por cromatografía líquida en fase inversa (RP-HPLC) para la determinación de Thimerosal (TMS) en cremas de uso tópico de acuerdo con las directrices de la ICH, que incluyen exactitud, precisión, selectividad, robustez, límite de detección, límite de cuantificación, linealidad e intervalo. Para cremas tópicas, el tratamiento de la muestra es a menudo un paso abrumador esencialmente debido a su naturaleza oleosa. Por primera vez se desarrolló con éxito, un simple y robusto procedimiento de extracción para TMS usando tampón de fosfato (pH 5.5, 0.2 M). Este método describe la cuantificación TMS por HPLC en un producto tópico que contiene 0.01% acetónido de fluocinolona (FLA) como la molécula activa. La separación por HPLC se logró en una columna Symmetry® y metanol: tampón de fosfato (pH 2.5, 0.05 M) 70:30 v/v y longitud de onda de 218 nm. Los resultados de ambos, patrones y muestras mostraron parámetros de validación adecuados. Es importante hacer notar que se demostró la linealidad 1.2-2.8 µg/mL. Además, se establecieron la robustez y la estabilidad TMS después de la extracción de la muestra. El método proporciona una herramienta de control de calidad eficiente y segura para la determinación de la TMS en cremas tópicas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[thimerosal]]></kwd>
<kwd lng="en"><![CDATA[topical cream]]></kwd>
<kwd lng="en"><![CDATA[RP-HPLC]]></kwd>
<kwd lng="en"><![CDATA[extraction]]></kwd>
<kwd lng="en"><![CDATA[validation]]></kwd>
<kwd lng="es"><![CDATA[timerosal]]></kwd>
<kwd lng="es"><![CDATA[crema tópica]]></kwd>
<kwd lng="es"><![CDATA[RP-HPLC]]></kwd>
<kwd lng="es"><![CDATA[extracción]]></kwd>
<kwd lng="es"><![CDATA[validación]]></kwd>
</kwd-group>
</article-meta>
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