<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-199X</journal-id>
<journal-title><![CDATA[Revista odontológica mexicana]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Odont. Mex]]></abbrev-journal-title>
<issn>1870-199X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Odontología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-199X2008000400184</article-id>
<article-id pub-id-type="doi">10.22201/fo.1870199xp.2008.12.4.15626</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectos de la mezcla de colágena-PVP, sobre el metabolismo y proliferación celular de fibroblastos gingivales humanos cultivados]]></article-title>
<article-title xml:lang="en"><![CDATA[Effects of the combination of collagen-PVP, over metaolism and cellular proliferation of gingival human cultivated fibroblasts]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Penilla Acasuso]]></surname>
<given-names><![CDATA[Izázkun G]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marín González]]></surname>
<given-names><![CDATA[Ma. Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Krötzsch Gómez]]></surname>
<given-names><![CDATA[Edgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salgado Curiel]]></surname>
<given-names><![CDATA[Rosa María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cano Colín]]></surname>
<given-names><![CDATA[Saúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM Facultad de Odontología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Rehabilitación  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Rehabilitación  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,ISSSTE Centro Médico Nacional &#8220;20 de Noviembre&#8221; ]]></institution>
<addr-line><![CDATA[México, D.F. ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2008</year>
</pub-date>
<volume>12</volume>
<numero>4</numero>
<fpage>184</fpage>
<lpage>191</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-199X2008000400184&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-199X2008000400184&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-199X2008000400184&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El propósito del presente estudio fue evaluar el efecto del fibroquel en la proliferación celular y la actividad metabólica en fibroblastos gingivales cultivados, para establecer las condiciones ideales para SU posterior uso en diversos procedimientos quirúrgicos, todo esto debido a que el fibroquel ha sido utilizado por más de 15 ańos en el tratamiento de diversos padecimientos y se han demostrado sus efectos en la aceleración del proceso de cicatrización. A fin de comprobar lo antes mencionado, se derivaron dos líneas celulares de biópsias realizadas en la zona palatina, de dos pacientes. Estas células fueron mantenidas en condiciones regulares de cultivo, una parte de la población celular fue congelada y otra parte fue utilizada para las pruebas de proliferación de actividad metabólica. Los resultados de ambas pruebas mostraron que en ninguna de las condiciones analizadas se afectó el comportamiento de las células de cultivo, en términos de proliferación o actividad metabólica, esto nos lleva a asumir que en la próxima investigación y protocolos clínicos, se usarán las concentraciones de fibroquel utilizadas en este estudio.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The purpose of this study was to evaluate the effect that the Fibroquel has over the cellular proliferation and the metabolic activity from cultivated gingival fibroblasts all this in order to stablished which condition would be the ideal for its posterior use in different surgical procedure, because this drug has been used over 15 years for the treatment of several fibrosant pathologies and it has been shown the effects over the acceleration of the cicatrizal process. In order to reach this goals two cellular lines were derived from palatine zone biopsies from two patients. This cells were kept in standard conditions of culture, this cells were sub-cultivated until the fourth pass, one part of the population was frozen and another part were utilized for the proliferation and metabolic activity assays. The results of both assays shown that none of the fibroquel conditions tested affected the behavior of the culture cells, this in terms of it proliferation or metabolic activity, this lead us to assume that in the next investigation and clinical protocols the concentrations of this drug will be used like we did in this study.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fibroquel]]></kwd>
<kwd lng="es"><![CDATA[fibroblastos gingivales]]></kwd>
<kwd lng="es"><![CDATA[proliferación y metabolismo celulares]]></kwd>
<kwd lng="en"><![CDATA[Fibroquel]]></kwd>
<kwd lng="en"><![CDATA[gingival fibroblasts]]></kwd>
<kwd lng="en"><![CDATA[cellulars proliferation and metabolism]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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