<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442023000400117</article-id>
<article-id pub-id-type="doi">10.24875/rmn.23000006</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Relevance of mitochondrial alterations in the neurodegenerative diseases, an update and discussion of evidence]]></article-title>
<article-title xml:lang="es"><![CDATA[Relevancia de las alteraciones mitocondriales en las enfermedades neurodegenerativas, una actualización y discusión de la evidencia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar-Gamas]]></surname>
<given-names><![CDATA[Carlos F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Abundis]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Crisóstomo]]></surname>
<given-names><![CDATA[Nancy P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz-Hernández]]></surname>
<given-names><![CDATA[Erick N. de la]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Juarez Autonomous University of Tabasco Multidisciplinary Academic Division of Comalcalco Laboratory of Research in Metabolic and Infectious Diseases]]></institution>
<addr-line><![CDATA[ Tabasco]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>24</volume>
<numero>4</numero>
<fpage>117</fpage>
<lpage>125</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442023000400117&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442023000400117&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442023000400117&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Neurodegenerative diseases (ND) are undoubtedly part of the more important health issues worldwide. The loss of independence and decreased quality of life are characteristics of these patients that translate into an economic load on relatives and health services. Although myriad factors or metabolic alterations are blamed as causatives, there is a common defect in almost every ND, mitochondrial dysfunction. Mitochondria are the cell&#8217;s leading energy supplier; therefore, altering its function will affect the cellular function with the energy demand. Defects in mitochondrial mechanisms such as ATP synthesis by the mitochondrial respiratory chain, mitochondrial dynamics, apoptosis regulation, and oxidative stress are described as part of the pathological characteristics of Alzheimer&#8217;s, Parkinson&#8217;s, Huntington&#8217;s diseases, and Amyotrophic Lateral Sclerosis. In this review, we will briefly describe the mitochondrial roles in cell life before analyzing the recently published bibliography that addresses the mitochondrial dysfunction and mitochondrial mechanisms implicated in ND and will discuss a relevant question in the field: is mitochondrial dysfunction a cause or consequence for these diseases?]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las enfermedades neurodegenerativas (EN) son, indudablemente, parte de los problemas de salud más importantes a nivel mundial. La pérdida de la independencia y disminución de la calidad de vida son características de estos pacientes que se traducen en una carga económica tanto para los familiares como para los servicios de salud. Aunque se han culpado a infinidad de factores o alteraciones metabólicas de ser los causantes, existe un defecto en común en casi toda las EN, la disfunción mitocondrial. La mitocondria es el principal proveedor de energía para la célula; por lo tanto, al alterar su función se verá afectada también la función celular en relación a la demanda de energía. Algunos defectos en los mecanismos mitocondriales como son la síntesis de ATP por la cadena respiratoria, la dinámica mitocondrial, la regulación de apoptosis, el estrés oxidativo, etc., se han descrito como parte de las características patológicas de enfermedades como Alzheimer, Parkinson, Huntington y Esclerosis Lateral Amiotrófica. En esta revisión describiremos brevemente las diferentes funciones mitocondriales en la vida de la célula, antes de analizar bibliografía recientemente publicada que aborda la disfunción y los mecanismos mitocondriales implicados en las EN y discutiremos una cuestión relevante en este campo: ¿Es la disfunción mitocondrial la causa o consecuencia de estas enfermedades?]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Neurodegenerative disease]]></kwd>
<kwd lng="en"><![CDATA[Mitochondrial dysfunction]]></kwd>
<kwd lng="en"><![CDATA[Alzheimer disease]]></kwd>
<kwd lng="en"><![CDATA[Parkinson disease]]></kwd>
<kwd lng="en"><![CDATA[Huntington disease]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad neurodegenerativa]]></kwd>
<kwd lng="es"><![CDATA[Disfunción mitocondrial]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Alzheimer]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Parkinson]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Huntington]]></kwd>
</kwd-group>
</article-meta>
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