<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442022000200071</article-id>
<article-id pub-id-type="doi">10.24875/rmn.21000020</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Role of the hypoxia-inducible factor (HIF) in the process of neurogenesis at the hippocampal level]]></article-title>
<article-title xml:lang="es"><![CDATA[Papel del factor inducible por hipoxia (HIF) en el proceso de neurogénesis a nivel hipocampal]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramirez-Rincón]]></surname>
<given-names><![CDATA[Clara L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,University of the Valley of Mexico School of Health Sciences ]]></institution>
<addr-line><![CDATA[Zapopan Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>23</volume>
<numero>2</numero>
<fpage>71</fpage>
<lpage>77</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442022000200071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442022000200071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442022000200071&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Hypoxia-induced factor 1 (HIF-1) plays a fundamental role in the response to low oxygen tension, since it regulates the expression of a wide variety of genes, whose products participate in processes such as angiogenesis, energy metabolism, erythropoiesis, and cell proliferation as well as in the process of neurogenesis, which involves various stages, such as proliferation of neuronal stem cells, migration, differentiation, survival of new neurons, and integration of the same. Among the many intrinsic and extrinsic molecular signals that regulate the production of new neurons from progenitor cells in the adult in the central nervous system (CNS), hypoxic damage plays an important role in the maintenance and function of stem cells in development and disease.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El factor 1 inducido por hipoxia (HIF-1) juega un papel fundamental en la respuesta a la baja tensión de oxígeno, ya que regula la expresión de una amplia variedad de genes cuyos productos participan en procesos como la angiogénesis, el metabolismo energético, la eritropoyesis y la proliferación celular. También participa en el proceso de neurogénesis, que involucra diversas etapas, como la proliferación de células madre neuronales, migración, diferenciación, supervivencia de nuevas neuronas e integración de las mismas. Entre las muchas señales moleculares intrínsecas y extrínsecas que regulan la producción de nuevas neuronas a partir de células progenitoras en el adulto en el sistema nervioso central (SNC), el daño hipóxico juega un papel importante en el mantenimiento y la función de las células madre en el desarrollo y la enfermedad.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[HIF]]></kwd>
<kwd lng="en"><![CDATA[Neurogénesis]]></kwd>
<kwd lng="en"><![CDATA[Hippocampus]]></kwd>
<kwd lng="en"><![CDATA[Hypoxic]]></kwd>
<kwd lng="en"><![CDATA[Wnt-catenin]]></kwd>
<kwd lng="es"><![CDATA[HIF]]></kwd>
<kwd lng="es"><![CDATA[Neurogénesis]]></kwd>
<kwd lng="es"><![CDATA[Hipocampo]]></kwd>
<kwd lng="es"><![CDATA[Hipoxia]]></kwd>
<kwd lng="es"><![CDATA[Wnt-catenina]]></kwd>
</kwd-group>
</article-meta>
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