<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442021000600224</article-id>
<article-id pub-id-type="doi">10.24875/rmn.21000032</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Depression is associated with CD4 levels in people living with HIV in Ecuador]]></article-title>
<article-title xml:lang="es"><![CDATA[Asociación entre conteo de CD4 y depresión en personas que viven con VIH en Ecuador]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Checa]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navas]]></surname>
<given-names><![CDATA[Eliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valencia]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alcívar]]></surname>
<given-names><![CDATA[Jessica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Especialidades Eugenio Espejo Unidad de Salud Mental ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>22</volume>
<numero>6</numero>
<fpage>224</fpage>
<lpage>228</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442021000600224&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442021000600224&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442021000600224&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: HIV can cause neurotoxicity and neuronal apoptosis, hence the importance of neuropathogenesis mechanisms in HIV. People in AIDS phase with CD4 count under 250, may be at greater risk of suffering from depression.  Objective: Evaluate whether there is a relationship between T-CD4 lymphocyte count and depression in people living with HIV but have not started antiretroviral treatment.  Method: This was a cross-sectional cohort study conducted between October 2020 and January 2021 in the HIV Unit of the Eugenio Espejo Hospital in Quito. A CD4 test was performed, and the Hamilton Depression Scale was used in patients after 1 month of being diagnosed with HIV but before receiving antiretroviral treatment.  Results: A total of 108 subjects were recruited, mainly men (79.6%), of which 82.4% were between 18 and 45 years old. The subjects in the AIDS phase were 25% of which 92.6% presented depression (p = 0.000), it was noted that the older the age, the prevalence of depression increases (p = 0.007). As for the female sex, it seems to have a risk of practically double with respect to men of suffering from depression (p = 0.005).  Conclusions: In our cohort study, at PLWH in Ecuador, patients in AIDS phase present a considerable risk of suffering from depression; at the same time, as the age increases, the probability of presenting depression is greater. As well as, female sex is a risk factor. Therefore, the follow-up of these patients is an essential part of care and treatment process.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: El VIH puede causar neurotoxicidad y apoptosis neuronal, de ahí la importancia de los mecanismos de su neuropatogénesis, las personas en fase de SIDA con conteo de CD4 inferior a 250 pueden tener mayor riesgo de padecer depresión.  Objetivo: Evaluar si existe relación entre el recuento de linfocitos T-CD4 y la depresión en personas viviendo con VIH en pacientes que no han iniciado tratamiento antirretroviral.  Método: Se trata de un estudio de cohorte transversal realizado entre octubre de 2020 y enero de 2021 en la Unidad de VIH del Hospital Eugenio Espejo de Quito. Se realizó una prueba de CD4 y se utilizó la Escala de Depresión de Hamilton en pacientes un mes después de ser diagnosticados con VIH y antes de recibir tratamiento antirretroviral.  Resultados: Se reclutaron 108 sujetos, principalmente hombres (79.6%), de los cuales el 82,4% tenían entre 18 y 45 años. Los sujetos en fase SIDA fueron 25% de los cuales 92.6% presentaron depresión (p = 0.000), a mayor edad aumenta la prevalencia de depresión (p = 0.007). En el sexo femenino el riesgo parece duplicar con respecto a los hombres de padecer depresión (p = 0,005).  Conclusiones: En nuestro estudio de cohorte, en PLWH, los pacientes en fase SIDA presentan un riesgo considerable de padecer depresión, a medida que aumenta la edad, la probabilidad de presentar depresión es mayor y el sexo femenino es un factor de riesgo. Por tanto, el seguimiento de estos pacientes es una parte fundamental del proceso de atención y tratamiento.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[CD4]]></kwd>
<kwd lng="en"><![CDATA[HIV]]></kwd>
<kwd lng="en"><![CDATA[Depression]]></kwd>
<kwd lng="es"><![CDATA[CD4]]></kwd>
<kwd lng="es"><![CDATA[VIH]]></kwd>
<kwd lng="es"><![CDATA[Depresión]]></kwd>
</kwd-group>
</article-meta>
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