<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442021000500180</article-id>
<article-id pub-id-type="doi">10.24875/rmn.21000010</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Mucuna pruriens as adjunct therapy to levodopa in advanced Parkinson's disease]]></article-title>
<article-title xml:lang="es"><![CDATA[Mucuna pruriens como terapia adjunta a levodopa en enfermedad de Parkinson avanzada]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Botello-Villagrana]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martinez-Ramirez]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico y de Estudios Superiores de Monterrey Escuela de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Monterrey NL]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<volume>22</volume>
<numero>5</numero>
<fpage>180</fpage>
<lpage>183</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442021000500180&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442021000500180&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442021000500180&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Parkinson's disease (PD) is a neurodegenerative disorder whose treatment in advanced stages is often complex and challenging. The treatment goal at this stage is to provide greater clinical stability, with less "off" time and longer "on" time. Mucuna pruriens (MP) is a legume plant traditionally used in Ayurvedic medicine for Parkinsonian-type diseases. This plant contains a diversity of elements, among which levodopa stands out.  Objective: We explored the effect of MP as adjunct therapy to levodopa in a PD patient.  Methods: We report the case of a 42-year-old woman with PD in advanced stages due to motor fluctuations and dyskinesias. Due to the progression of her disease, the limitations that it generates and the economic inability to opt for other therapies such as surgical treatments, we used MP as an adjunct therapy to levodopa.  Results: MP produces a clinical motor effect similar to conventional levodopa. MP shortened the time to reach the "on" state and prolonged this state without exacerbating dyskinesias. Psychiatric side effects were observed only with high dosages of MP.  Conclusions: MP shows to be a promising adjunct therapy to levodopa in advanced PD patients without access to other conventional therapies.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La enfermedad de Parkinson (EP) es un trastorno neurodegenerativo cuyo tratamiento en etapas avanzadas suele ser complejo y desafiante. El objetivo del tratamiento en esta etapa es proporcionar una mayor estabilidad clínica, con menos tiempo de "apagado" y más tiempo de "encendido". Mucuna pruriens (MP) es una planta leguminosa utilizada tradicionalmente en la medicina ayurvédica para las enfermedades de tipo parkinsoniano. Esta planta contiene diversidad de elementos, entre los que destaca la levodopa.  Objetivo: Exploramos el efecto de la MP como terapia coadjuvante a levodopa en un paciente con EP.  Métodos: Presentamos el caso de una mujer de 42 años con EP en estadios avanzados por fluctuaciones motoras y discinesias. Debido a la progresión de su enfermedad, las limitaciones que genera y la imposibilidad económica de optar por otras terapias como los tratamientos quirúrgicos, utilizamos MP como terapia coadyuvante a la levodopa.  Resultados: La MP produce un efecto clínico motor similar al de levodopa convencional. MP acortó el tiempo para el estado "on" medicamentoso y lo prolongó este mismo estado sin exacerbar las discinesias. Se observaron efectos secundarios psiquiátricos con dosis altas de MP.  Conclusiones: La MP parece ser una terapia coadyuvante prometedora a la levodopa para pacientes con EP avanzada sin acceso a otras terapias convencionales.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Parkinson's disease]]></kwd>
<kwd lng="en"><![CDATA[Mucuna pruriens]]></kwd>
<kwd lng="en"><![CDATA[Levodopa]]></kwd>
<kwd lng="en"><![CDATA[Motor fluctuations]]></kwd>
<kwd lng="en"><![CDATA[Dyskinesia]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Parkinson]]></kwd>
<kwd lng="es"><![CDATA[Mucuna pruriens]]></kwd>
<kwd lng="es"><![CDATA[Levodopa]]></kwd>
<kwd lng="es"><![CDATA[Fluctuaciones motoras]]></kwd>
<kwd lng="es"><![CDATA[Discinesias]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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