<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442020000100003</article-id>
<article-id pub-id-type="doi">10.24875/rmn.19000102</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Differences in stroke patterns and outcomes between cancer and non-cancer patients]]></article-title>
<article-title xml:lang="es"><![CDATA[Diferencias y desenlaces acorde al patrón de presentación de eventos vasculares cerebrales (EVC) en pacientes con cáncer y sin cáncer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cacho-Díaz]]></surname>
<given-names><![CDATA[Bernardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spínola-Maroño]]></surname>
<given-names><![CDATA[Héctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza-Olivas]]></surname>
<given-names><![CDATA[Laura G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salmerón-Moreno]]></surname>
<given-names><![CDATA[Karen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monroy-Sosa]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cantú-Brito]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Candelaria-Hernández]]></surname>
<given-names><![CDATA[Myrna G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Cancerología Neuro-Oncology Unit ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Neurology and Psychiatry ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Cancerología Research Unit ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<volume>21</volume>
<numero>1</numero>
<fpage>3</fpage>
<lpage>8</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442020000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442020000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442020000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: One in 10 patients with stroke concurrently has cancer; however, the impact of their combination on survival has not been well established; consequently, stroke and cancer are likely to have unrecognized associations.  Objective: The objective of the study was to compare the stroke risk factors, presentations, and outcomes between stroke patients with and without cancer, to recognize this as an added hazard element that might impact mortality rates.  Methods: Data were prospectively acquired at a cancer referral center from March 2011 to February 2018. Patients with histologically confirmed diagnosis of cancer, who were sent for neuro-oncology consultation and showed evidence by MRI of suffering a stroke during follow-up were compared with a previously reported cohort of patients with stroke and similar demographic characteristics (RENAMEVASC and PREMIER studies), employing Student's t-test after determining the mean and standard deviation using Hazen's equation.  Results: A total of 270 patients with cancer-related stroke were compared to 2000 patients with non-cancer stroke. Stroke risk factors for the cohort of patients with cancer were dyslipidemia, alcohol abuse, and tobacco use, with a median follow-up after the stroke of 13.8 months. Mortality rates at 30 and 90-days were similar between both groups; however, at 6 and 12-months they were higher in patients with cancer-related stroke (6 months: 37 vs. 23%, RR 1.62, p &lt; 0.0001; 12 months: 43 vs. 29%, RR 1.48, p = 0.00001).  Conclusion: Mid-term and long-term survival rates were worse in cancer patients with stroke compared with those without cancer.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Uno de cada 10 pacientes que sufre un EVC tiene algún tipo de cáncer concomitante, sin embargo, el impacto de esta combinación no ha sido bien establecido. En consecuencia, es probable que el EVC y el cáncer presenten asociaciones no reconocidas.  Objetivo: Comparar factores de riesgo, formas de presentación y desenlace en pacientes con cáncer y sin cáncer que sufrieron EVC, en función de reconocerlo como elemento adicional de riesgo que puede impactar sobre las tasas de mortalidad.  Métodos: Se recopilaron datos prospectivamente en un centro de referencia oncológico desde marzo 2011 a febrero 2018. Pacientes con diagnóstico de cáncer confirmado por histopatología que fueron enviados a consulta de neuro-oncología y evidenciaron por medio de IRM algún tipo de EVC durante el seguimiento, se compararon contra una cohorte previamente reportada de pacientes con EVC sin relación a cáncer y características demográficas similares (estudios RENAMEVASC y PREMIER), empleando t de Student después de determinar la media y la desviación estándar con la ecuación de Hozo.  Resultados: Se comparó un total de 270 pacientes con EVC relacionado a cáncer contra 2,000 pacientes con EVC. Los factores de riesgo de EVC para la cohorte de pacientes con cáncer fueron dislipidemia, abuso de alcohol y uso de tabaco, con una mediana de seguimiento de 13.8 meses después del EVC. La tasa de mortalidad a 30 y 90 días fue similar en ambos grupos; sin embargo, a 6 y 12 meses fue mayor en el grupo de EVC relacionado a cáncer (6 meses: 37% vs. 23%, RR 1.62, p &lt; 0.0001; 12 meses: 43% vs. 29%, RR 1.48, p = 0.00001).  Conclusión: A mediano y largo plazo las tasas de supervivencia empeoraron en pacientes con EVC relacionado a cáncer.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[Stroke]]></kwd>
<kwd lng="en"><![CDATA[Survival]]></kwd>
<kwd lng="en"><![CDATA[Mortality rates]]></kwd>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[Evento vascular cerebral]]></kwd>
<kwd lng="es"><![CDATA[Supervivencia]]></kwd>
<kwd lng="es"><![CDATA[Tasa de supervivencia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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