<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442019000400174</article-id>
<article-id pub-id-type="doi">10.24875/rmn.m19000067</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores asociados a la enfermedad de Parkinson en pacientes de la Comarca Lagunera, México]]></article-title>
<article-title xml:lang="en"><![CDATA[Factors associated with Parkinson&#8217;s disease in patients from the Comarca Lagunera, Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ventura-Chávez]]></surname>
<given-names><![CDATA[Raymundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyna-Gil]]></surname>
<given-names><![CDATA[Ana I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidades Médicas de Alta Especialidad Departamento de Neurología y Psicología ]]></institution>
<addr-line><![CDATA[Torreón ]]></addr-line>
<country>Coahuila</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Departamento de Medicina Interna Hospital General de Zona n.º 51 Gómez Palacio]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Departamento de Investigación Clínica Centro Médico Nacional 20 de Noviembre]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>20</volume>
<numero>4</numero>
<fpage>174</fpage>
<lpage>179</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442019000400174&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442019000400174&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442019000400174&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La enfermedad de Parkinson (EP) es un padecimiento neurodegenerativo progresivo, incapacitante e incurable; en el 90% de los casos es de etiología poligénica y multifactorial. La Comarca Lagunera es la novena zona más poblada de México, está ubicada en el centro-norte; aquí las concentraciones de arsénico, cadmio y plomo superan en 1-3 órdenes de magnitud los niveles aceptables.  Objetivo: El objetivo de esta investigación fue evaluar la asociación de los factores ambientales en el desarrollo de la EP en esta región.  Material y métodos: Se incluyeron pacientes y sujetos controles de más de 18 años que aceptaron participar firmando el consentimiento informado escrito, oriundos y residentes de la Comarca Lagunera; el diagnóstico de EP se determinó de acuerdo con los Criterios diagnósticos del Banco de Cerebros del Reino Unido; los controles fueron personas sanas y sin antecedentes de enfermedad neurológica. En todos se realizó una evaluación neurológica completa.  Resultados: Se incluyeron 204 personas: 60 con diagnóstico de EP y 144 controles; encontramos que el consumo de tabaco, café y té se asociaban negativamente con el desarrollo de EP, en tanto que la ubicación de la vivienda, la fuente del agua de consumo, y el contacto con pesticidas y plomo no mostraron asociación.  Conclusiones: En concordancia con otros estudios, el tabaquismo, el consumo de café y de té se asociaron negativamente al desarrollo de EP, en tanto que el consumo de agua de pozo, exposición a pesticidas y/o plomo, y tipo de vivienda rural no tuvieron asociación; así, su presunta participación como «detonadores» de la enfermedad sigue siendo controvertida.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Parkinson&#8217;s disease (PD) is a progressive, incapacitating and incurable neurodegenerative disease; in 90% of cases its etiology is polygenic and multifactorial. Comarca Lagunera is the ninth most populated area of Mexico, located in the center-north; its concentrations of arsenic, cadmium and lead exceed in 1-3 orders of magnitude acceptable levels.  Objective: To evaluate the association of environmental factors with the development of PD in this region.  Materials and Methods: Patients and controls were more of 18 years old, they agreed to participate with the signature of the informed consent; they were natives and residents of Lagunera region; PD diagnosis was made according Diagnostic Criteria of the Brain Bank of the United Kingdom; controls were healthy people without history of neurological disease. All of them underwent neurological evaluation.  Results: 204 people were included: 60 persons with PD diagnoses and 144 controls; consumption of tobacco, coffee and tea were associated to negative effect to develop PD, while rural housing, source of water consumption, and the exposition to pesticides and lead were not associated to PD.  Conclusions: In accordance with other studies, smoking, consumption of coffee and tea were protective factors for the development of PE, while consumption water well, exposure to pesticides and/or lead, and rural housing were not associated to PD; so, their presumed participation as &#8220;triggers&#8221; of the disease remains controversial.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad de Parkinson]]></kwd>
<kwd lng="es"><![CDATA[Factores ambientales]]></kwd>
<kwd lng="es"><![CDATA[Área de la Comarca Lagunera]]></kwd>
<kwd lng="en"><![CDATA[Parkinson&#8217;s disease]]></kwd>
<kwd lng="en"><![CDATA[Environmental factors]]></kwd>
<kwd lng="en"><![CDATA[Comarca Lagunera area]]></kwd>
</kwd-group>
</article-meta>
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