<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442019000200069</article-id>
<article-id pub-id-type="doi">10.24875/rmn.m19000058</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Guía clínica. Suspensión del tratamiento crónico con antiepilépticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical guide: discontinuing chronic antiepileptic drug treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Loy-Gerala]]></surname>
<given-names><![CDATA[María del C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibarra-Bravo]]></surname>
<given-names><![CDATA[Octavio M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Márquez-Estudillo]]></surname>
<given-names><![CDATA[María del R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mena-Barranco]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rogel-Ortiz]]></surname>
<given-names><![CDATA[Francisco J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva-Sánchez]]></surname>
<given-names><![CDATA[Sandra E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villegas-Peña]]></surname>
<given-names><![CDATA[Hilda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Molina-García]]></surname>
<given-names><![CDATA[Avril]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General de Puebla Dr. Eduardo Vázquez Navarro  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Dr. Miguel Silva  ]]></institution>
<addr-line><![CDATA[Morelia Michoacán]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado Hospital Regional de Alta Especialidad ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado Hospital General ]]></institution>
<addr-line><![CDATA[La Paz Baja California Sur]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,PPE  ]]></institution>
<addr-line><![CDATA[Veracruz ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Central Universitario  ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,PPE  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Hospital Infantil de Especialidades  ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>20</volume>
<numero>2</numero>
<fpage>69</fpage>
<lpage>74</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442019000200069&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442019000200069&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442019000200069&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La decisión de continuar o retirar los fármacos antiepilépticos (FAE) debe ser tomada en conjunto por el paciente, la familia y/o los cuidadores y el médico especialista, después de una amplia información y discusión de los riesgos y beneficios de su retirada. El paciente y los familiares deben comprender que hay un riesgo de recurrencia de crisis con y sin FAE y se debe tomar en cuenta el tipo de epilepsia, el pronóstico de esta y el estilo de vida del paciente. El retiro debe ser bajo la supervisión de un especialista (neurólogo clínico) y se considerará cuando se hayan cumplido por los menos dos años sin crisis. El tratamiento será retirado de manera gradual en un lapso de al menos 2-3 meses y se retirarán los antiepilépticos de uno por uno. El retiro de benzodiacepinas y barbitúricos será más lento, en no menos de 6 meses o más. Se deberá tener un acuerdo de que en caso de recaída de crisis se regresará a la última dosis previa a la dosis en la cual se presentó la recaída y se solicitará valoración por el especialista.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The decision to continue or withdraw the antiepileptic drugs (AEDs) should be taken jointly by the patient, family and/or caregivers and the specialist physician, after extensive information and discussion of the risks and benefits of the withdrawal of the AED. The patient and family members must understand that there is a risk of recurrence of seizures with and without AEDs. The type of epilepsy, the prognosis and the patient’s lifestyle should be considered. The withdrawal should be made under the supervision of a specialist (clinical neurologist) and will be considered when they have been fulfilled for at least two years without seizures. The treatment will be gradually withdrawn within a period of at least 2-3 months and the antiepileptics will be removed one by one. Withdrawal of benzodiazepines and barbiturates will be slower, in no &lt;6 months or more. An agreement must be made with respect that in the event of a seizure relapse, the patient will return to the last dose prior to the dose in which the relapse was presented and a clinical neurology interview will also be requested.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Retirar]]></kwd>
<kwd lng="es"><![CDATA[Fármacos antiepilépticos]]></kwd>
<kwd lng="es"><![CDATA[Detener los fármacos antiepilépticos]]></kwd>
<kwd lng="en"><![CDATA[Withdraw]]></kwd>
<kwd lng="en"><![CDATA[Antiepileptic drugs]]></kwd>
<kwd lng="en"><![CDATA[Stop antiepileptic drugs]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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