<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442019000200025</article-id>
<article-id pub-id-type="doi">10.24875/rmn.m19000055</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Guía clínica. Fármacos antiepilépticos de elección para crisis focales y generalizadas en adultos]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical guideline. Antiepileptic drugs of choice for focal and generalized seizures in adult patients with epilepsy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Castaño]]></surname>
<given-names><![CDATA[Leopoldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sentíes-Madrid]]></surname>
<given-names><![CDATA[Horacio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Berumen-Jaik]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Juárez]]></surname>
<given-names><![CDATA[Iris E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,CIMA Centro Internacional de Medicina  ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Infantil Universitario  ]]></institution>
<addr-line><![CDATA[Torreón ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Dr. Manuel Velasco Suárez  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>20</volume>
<numero>2</numero>
<fpage>25</fpage>
<lpage>32</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442019000200025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442019000200025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442019000200025&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El pilar del tratamiento en pacientes con epilepsia son los fármacos antiepilépticos (FAE). En la actualidad se cuenta con un número importante de FAE en México. Para el manejo farmacológico del paciente con epilepsia se debe conocer la farmacocinética de los FAE, dosis, mecanismo de acción y formulaciones. La monoterapia permite la ausencia absoluta de crisis en entre el 70 y el 80% de los pacientes con epilepsias, ya sean focales o generalizadas. Cuando a pesar del uso de un FAE en monoterapia no se logre el control de las crisis epilépticas se debe considerar el uso de un segundo FAE, situación en la cual se propone la combinación en forma empírica de FAE con diferentes mecanismos de acción. En el paciente que persiste con crisis epilépticas con el uso de un FAE adecuado, a dosis adecuadas y con adherencia terapéutica deberá considerarse nuevamente el diagnóstico correcto del tipo de crisis y el diagnóstico diferencial, con una nueva evaluación clínica y de estudios de gabinete.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The mainstay of treatment in patients with epilepsy is the use of antiepileptic drugs (AEDs). Currently, there are a significant number of AEDs in Mexico. For the pharmacological management of the patient with epilepsy, it is important to know the pharmacokinetics, dosage, mechanism of action, and formulations of the AEDs. 70-80% of patients with either focal or generalized seizures are completely seizure free on AED monotherapy. When, despite the use of AED in monotherapy, seizure freedom is not achieved, a second AED should be used; AEDs with different mechanisms of action are empirically combined for this purpose. If a patient persists in having seizures with the use of an adequate AED, at appropriate doses and with therapeutic adherence, a correct diagnosis of the seizure type and a differential diagnosis should be reconsidered using a new clinical evaluation and auxiliary diagnostic tests.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fármacos antiepilépticos]]></kwd>
<kwd lng="es"><![CDATA[Monoterapia]]></kwd>
<kwd lng="es"><![CDATA[Politerapia]]></kwd>
<kwd lng="es"><![CDATA[Adulto]]></kwd>
<kwd lng="en"><![CDATA[Antiepileptic drug]]></kwd>
<kwd lng="en"><![CDATA[Monotherapy]]></kwd>
<kwd lng="en"><![CDATA[Polytherapy]]></kwd>
<kwd lng="en"><![CDATA[Adult]]></kwd>
</kwd-group>
</article-meta>
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