<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1456</journal-id>
<journal-title><![CDATA[Biotecnia]]></journal-title>
<abbrev-journal-title><![CDATA[Biotecnia]]></abbrev-journal-title>
<issn>1665-1456</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ciencias Biológicas y de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-14562024000100201</article-id>
<article-id pub-id-type="doi">10.18633/biotecnia.v26.2287</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La proteína Alfa-1 antitripsina y su papel en la fisiopatología del cáncer]]></article-title>
<article-title xml:lang="en"><![CDATA[Alpha-1-antitrypsin protein and its role in the pathophysiology of cancer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Avalos-Navarro]]></surname>
<given-names><![CDATA[Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Patiño]]></surname>
<given-names><![CDATA[Ramiro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jave-Suárez]]></surname>
<given-names><![CDATA[Luis Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Uribe]]></surname>
<given-names><![CDATA[Emmanuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guadalajara Departamento de Ciencias Médicas y de la Vida ]]></institution>
<addr-line><![CDATA[Ocotlán Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social División de Inmunología ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>26</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-14562024000100201&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-14562024000100201&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-14562024000100201&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La proteína &#945;1-AT posee una amplia gama de funciones biológicas, su función principal es proteger al pulmón contra las elastasas producidas por los neutrófilos. Sin embargo, también está relacionada con diferentes procesos patológicos, como el cáncer. Entre los tipos de cáncer a los que se ha asociado se encuentra cáncer de mama, próstata, pulmón, cuello uterino, vejiga y colorrectal, entre otros. Asimismo, diferentes estudios han reportado concentraciones aumentadas en los pacientes con cáncer en comparación con sujetos control. Además, la proteína &#945;1-AT ha sido propuesta como un posible biomarcador en diferentes tipos de cáncer y se ha relacionado con la progresión tumoral. Actualmente, los mecanismos fisiopatológicos y moleculares de la &#945;1-AT en el cáncer aun no son claros. Sin embargo, podría estar participando en diferentes procesos biológicos y moleculares en el microambiente tumoral, lo que podría ser una causa del aumento de la concentración sistémica. En conclusión, el presente trabajo se enfoca en describir la estructura de la &#945;1-AT y recopilar sus funciones más relevantes en procesos fisiológicos y patológicos, como el cáncer.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The &#945;1-AT protein has a wide range of biological functions, mainly protecting the lung against elastases produced by neutrophils. However, it is also related to different pathological processes, such as cancer. Among the types of cancer with which it has been associated are breast, prostate, lung, cervical, bladder and colorectal cancer, among others. Likewise, different studies have reported increased concentrations in cancer patients compared to control subjects. Furthermore, the &#945;1-AT protein has been proposed as a possible biomarker in different types of cancer, and has been related to tumor progression. Currently, the pathophysiological and molecular mechanisms of &#945;1-AT in cancer are still unclear. However, it could be participating in different biological and molecular processes in the tumor microenvironment, which could be a cause of the increase in systemic concentration. In conclusion, the present work focuses on describing the structure of &#945;1-AT and collecting its most relevant functions in physiological and pathological processes, such as cancer.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Antiproteasa]]></kwd>
<kwd lng="es"><![CDATA[Progresión tumoral]]></kwd>
<kwd lng="es"><![CDATA[Inflamación]]></kwd>
<kwd lng="es"><![CDATA[Matriz extracelular]]></kwd>
<kwd lng="es"><![CDATA[Respuesta inmune]]></kwd>
<kwd lng="en"><![CDATA[Antiprotease]]></kwd>
<kwd lng="en"><![CDATA[Tumoral progression]]></kwd>
<kwd lng="en"><![CDATA[Inflammation]]></kwd>
<kwd lng="en"><![CDATA[Extracellular matrix]]></kwd>
<kwd lng="en"><![CDATA[Immune response]]></kwd>
</kwd-group>
</article-meta>
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