<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1456</journal-id>
<journal-title><![CDATA[Biotecnia]]></journal-title>
<abbrev-journal-title><![CDATA[Biotecnia]]></abbrev-journal-title>
<issn>1665-1456</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ciencias Biológicas y de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-14562020000200050</article-id>
<article-id pub-id-type="doi">10.18633/biotecnia.v22i2.1245</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inhibición de lipasa pancreática por flavonoides: importancia del doble enlace C2=C3 y la estructura plana del anillo C]]></article-title>
<article-title xml:lang="en"><![CDATA[Inhibition of pancreatic lipase by flavonoids: relevance of the C2=C3 double bond and C-ring planarity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martinez-Gonzalez]]></surname>
<given-names><![CDATA[Alejandra Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Sánchez]]></surname>
<given-names><![CDATA[Ángel Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[Laura Alejandra de la]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bustos-Jaimes]]></surname>
<given-names><![CDATA[Ismael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vazquez-Flores]]></surname>
<given-names><![CDATA[Alma A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarez-Parrilla]]></surname>
<given-names><![CDATA[Emilio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Ciudad Juárez Instituto de Ciencias Biomédicas Departamento de Ciencias Químico Biológicas]]></institution>
<addr-line><![CDATA[Ciudad Juárez ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Departamento de Bioquímica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>22</volume>
<numero>2</numero>
<fpage>50</fpage>
<lpage>60</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-14562020000200050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-14562020000200050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-14562020000200050&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Lipasa pancreática es una enzima clave en el metabolismo de lípidos. Los flavonoides son compuestos bioactivos de gran relevancia debido a sus interacciones con enzimas digestivas. Se evaluó la actividad de lipasa pancreática en presencia de flavonoides. Mediante espectroscopía UV Visible se determinó que el mejor inhibidor fue quercetina, seguido de rutina &gt; luteolina &gt; catequina &gt; hesperetina, con valores de IC50 de 10.30, 13.50, 14.70, 28.50 y 30.50 µM, respectivamente. Todos los flavonoides mostraron una inhibición mixta, excepto catequina que mostró una inhibición acompetitiva. La capacidad inhibitoria de los flavonoides se relacionó con propiedades estructurales compartidas entre los distintos flavonoides, como la hidroxilación en las posiciones C5, C7 (anillo A), C2&#8217; y C3&#8217; (anillo B), y el doble enlace entre C2 y C3 (anillo C). Los resultados de inhibición coincidieron con el análisis de la fluorescencia extrínseca. Los estudios de docking molecular indicaron que la interacción entre lipasa pancreática y los flavonoides fue principalmente mediante interacciones hidrofóbicas (pi-stacking). Las interacciones de todos los flavonoides, excepto rutina, se dieron en el mismo sitio (subsitio 1) de la enzima. La insaturación entre C2 y C3 fue determinante para el acomodo de los flavonoides con la enzima, principalmente por interacciones de pi-stacking.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Pancreatic lipase is a key enzyme in lipid metabolism. Flavonoids are bioactive compounds obtained from vegetables with big relevance, due to their intrinsic interaction with digestive enzymes. Pancreatic lipase activity was evaluated in the presence of flavonoids, through UV-Vis spectroscopy. All tested flavonoids showed a mixed-type inhibition, except catechin, which showed a uncompetitive inhibition. The best inhibitor was quercetin followed by rutin &gt; luteolin &gt; catechin &gt; hesperetin, with IC50 values of 10.30, 13.50, 14.70, 28.50 and 30.50 µM, respectively. The flavonoids inhibitory capacity was related to structural properties shared between the different flavonoids, such as the hydroxylation at C5, C7 (ring A), C2&#8217; and C3&#8217; (ring B), and the double bond between C2 and C3 (ring C). The inhibition results are in agreement with the extrinsic fluorescence analysis. Molecular docking studies indicated that the interaction between pancreatic lipase and flavonoids was mainly through hydrophobic interactions (pi-stacking). The interactions of all flavonoids, except rutin, occurred at the same enzyme site (subsite 1). Instauration between C2 and C3 was decisive for the arrangement of flavonoids with the enzyme, mainly due to pi-stacking interactions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Lipasa pancreática]]></kwd>
<kwd lng="es"><![CDATA[flavonoide]]></kwd>
<kwd lng="es"><![CDATA[estructura plana]]></kwd>
<kwd lng="es"><![CDATA[sitio de unión]]></kwd>
<kwd lng="en"><![CDATA[Pancreatic lipase]]></kwd>
<kwd lng="en"><![CDATA[flavonoid]]></kwd>
<kwd lng="en"><![CDATA[planarity]]></kwd>
<kwd lng="en"><![CDATA[binding site]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Acharya]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Madhusudhana]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stability Studies on a Lipase from Bacillus subtilis in Guanidinium Chloride]]></article-title>
<source><![CDATA[Journal of Protein Chemistry]]></source>
<year>2003</year>
<volume>22</volume>
<page-range>51-60</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amat]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Sgamellotti]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Fantacci]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Theoretical Study of the Structural and Electronic Properties of Luteolin and Apigenin Dyes]]></source>
<year>2008</year>
<publisher-loc><![CDATA[Berlin, Heidelberg ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Birari]]></surname>
<given-names><![CDATA[R.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Bhutani]]></surname>
<given-names><![CDATA[K.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pancreatic lipase inhibitors from natural sources: unexplored potential]]></article-title>
<source><![CDATA[Drug Discovery Today]]></source>
<year>2007</year>
<volume>12</volume>
<page-range>879-89</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Birari]]></surname>
<given-names><![CDATA[R.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Gopi Mohan]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Bhutani]]></surname>
<given-names><![CDATA[K.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiobesity and Lipid Lowering Effects of Glycyrrhiza Chalcones: Experimental and Computational Studies]]></article-title>
<source><![CDATA[Phytomedicine]]></source>
<year>2011</year>
<volume>18</volume>
<page-range>795-801</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buchholz]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Melzig]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Polyphenolic Compounds as Pancreatic Lipase Inhibitors]]></article-title>
<source><![CDATA[Planta Medica]]></source>
<year>2015</year>
<volume>81</volume>
<page-range>771-83</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calabrone]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Larocca]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Marzocco]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Martelli]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Rossano]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Total phenols and flavonoids content, antioxidant capacity and lipase inhibition of root and leaf horseradish (Armoracia rusticana) extracts]]></article-title>
<source><![CDATA[Food and Nutrition Sciences]]></source>
<year>2015</year>
<volume>6</volume>
<page-range>64-74</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cerezo]]></surname>
<given-names><![CDATA[A.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Winterbone]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Moyle]]></surname>
<given-names><![CDATA[C.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Needs]]></surname>
<given-names><![CDATA[P.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Kroon]]></surname>
<given-names><![CDATA[P.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular structure&#8208;function relationship of dietary polyphenols for inhibiting VEGF&#8208;induced VEGFR&#8208;2 activity molecular]]></article-title>
<source><![CDATA[Nutrition &amp; Food Research]]></source>
<year>2015</year>
<volume>59</volume>
<page-range>2119-31</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cook]]></surname>
<given-names><![CDATA[N.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Samman]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources]]></article-title>
<source><![CDATA[The Journal of Nutritional Biochemistry]]></source>
<year>1996</year>
<volume>7</volume>
<page-range>66-76</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dalar]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Konczak]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenolic contents, antioxidant capacities and inhibitory activities against key metabolic syndrome relevant enzymes of herbal teas from Eastern Anatolia]]></article-title>
<source><![CDATA[Industrial Crops and Products]]></source>
<year>2013</year>
<volume>44</volume>
<page-range>383-90</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Vivo]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Masetti]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Bottegoni]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Cavalli]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of molecular dynamics and related methods in drug discovery]]></article-title>
<source><![CDATA[Journal of Medicinal Chemistry]]></source>
<year>2016</year>
<volume>59</volume>
<page-range>4035-61</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Egloff]]></surname>
<given-names><![CDATA[M.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Sarda]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Verger]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Cambillau]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Tilbeurgh]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Crystallographic study of the structure of colipase and of the interaction with pancreatic lipase]]></article-title>
<source><![CDATA[Protein Science]]></source>
<year>1995</year>
<volume>4</volume>
<page-range>44-57</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erlund]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology]]></article-title>
<source><![CDATA[Nutrition Research]]></source>
<year>2004</year>
<volume>24</volume>
<page-range>851-74</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gasymov]]></surname>
<given-names><![CDATA[O.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Glasgow]]></surname>
<given-names><![CDATA[B.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ANS fluorescence: Potential to augment the identification of the external binding sites of proteins]]></article-title>
<source><![CDATA[Biochimica et Biophysica Acta]]></source>
<year>2007</year>
<volume>1774</volume>
<page-range>403-11</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gonzales]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Smagghe]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Grootaert]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Zotti]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Raes]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Camp]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure- activity/property relationship-based approach in the study of bioavailability and bioactivity]]></article-title>
<source><![CDATA[Drug Metabolism Reviews]]></source>
<year>2015</year>
<volume>47</volume>
<page-range>175-90</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Halim]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zaroog]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Kadir]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Tayyab]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alcohol-induced structural transitions in the acid-denatured Bacillus licheniformis &#945;-amylase]]></article-title>
<source><![CDATA[Journal of Saudi Chemical Society]]></source>
<year>2017</year>
<volume>21</volume>
<page-range>S349-58</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Harborne]]></surname>
<given-names><![CDATA[J.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plant polyphenols-XI.: The structure of acylated anthocyanins]]></article-title>
<source><![CDATA[Phytochemistry]]></source>
<year>1964</year>
<volume>3</volume>
<page-range>151-60</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hawe]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Sutter]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jiskoot]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extrinsic Fluorescent Dyes as Tools for Protein Characterization]]></article-title>
<source><![CDATA[Pharmaceutical Research]]></source>
<year>2008</year>
<volume>25</volume>
<page-range>1487-99</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Lv]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Yao]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of tea polyphenols on the activities of &#945;-amylase, pepsin, trypsin and lipase]]></article-title>
<source><![CDATA[Food Chemistry]]></source>
<year>2006</year>
<volume>101</volume>
<page-range>1178-82</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heim]]></surname>
<given-names><![CDATA[K.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Tagliaferro]]></surname>
<given-names><![CDATA[A.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Bobilya]]></surname>
<given-names><![CDATA[D.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships]]></article-title>
<source><![CDATA[The Journal of Nutritional Biochemistry]]></source>
<year>2002</year>
<volume>13</volume>
<page-range>572-84</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[F.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Yin]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Zeng]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Caffeoylquinic acids competitively inhibit pancreatic lipase through binding to the catalytic triad]]></article-title>
<source><![CDATA[International Journal of Biological Macromolecules]]></source>
<year>2015</year>
<volume>80</volume>
<page-range>529-35</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[W.Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[Y.Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Natural phenolic compounds from medicinal herbs and dietary plants: Potential use for cancer prevention]]></article-title>
<source><![CDATA[Nutrition and Cancer]]></source>
<year>2009</year>
<volume>62</volume>
<page-range>120</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kokotos]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of digestive lipases by 2-oxo amide triacylglycerol analogues]]></article-title>
<source><![CDATA[Journal of Molecular Catalysis B: Enzymatic]]></source>
<year>2003</year>
<volume>22</volume>
<page-range>255-69</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kuhnert]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Dairpoosh]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Jaiswal]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Matei]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Deshpande]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Golon]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Nour]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Karaköse]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Hourani]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?]]></article-title>
<source><![CDATA[Journal of Chemical Biology]]></source>
<year>2011</year>
<volume>4</volume>
<page-range>109-16</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[J.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Yoon]]></surname>
<given-names><![CDATA[N.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[B.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[S.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Gopalan]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Jeong]]></surname>
<given-names><![CDATA[H.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[S.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[D.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[S.W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Response characterization of a fiber optic sensor array with dyecoated planar waveguide for detection of volatile organic compounds]]></article-title>
<source><![CDATA[Sensors]]></source>
<year>2014</year>
<volume>14</volume>
<page-range>11659-71</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Yuan]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Ning]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interaction between four flavonoids and trypsin: effect on the characteristics of trypsin and antioxidant activity of flavonoids]]></article-title>
<source><![CDATA[International Journal of Food Science &amp; Technology]]></source>
<year>2014</year>
<volume>49</volume>
<page-range>1063-9</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y.Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Fei]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Probing the interaction between 3 flavonoids and pancreatic lipase by methods of fluorescence spectroscopy and enzymatic kinetics]]></article-title>
<source><![CDATA[European Food Research and Technology]]></source>
<year>2011</year>
<volume>233</volume>
<page-range>63-9</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lo Piparo]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Scheib]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Frei]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Williamson]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Grigorov]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Chou]]></surname>
<given-names><![CDATA[C.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flavonoids for controlling starch digestion: Structural requirements for inhibiting human &#945;-amylase]]></article-title>
<source><![CDATA[Journal of Medicinal Chemistry]]></source>
<year>2008</year>
<volume>51</volume>
<page-range>3555-61</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martinez-Gonzalez]]></surname>
<given-names><![CDATA[A.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Alvarez-Parrilla]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Sánchez]]></surname>
<given-names><![CDATA[Á.G.]]></given-names>
</name>
<name>
<surname><![CDATA[de la Rosa]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Núñez-Gastélum]]></surname>
<given-names><![CDATA[J.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Vazquez-Flores]]></surname>
<given-names><![CDATA[A.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez-Aguilar]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In Vitro Inhibition of pancreatic lipase by polyphenols: A kinetic, fluorescence spectroscopy and molecular docking study]]></article-title>
<source><![CDATA[Food Technology and Biotechnology]]></source>
<year>2017</year>
<volume>55</volume>
<page-range>519-30</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martinez-Gonzalez]]></surname>
<given-names><![CDATA[A.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Sánchez]]></surname>
<given-names><![CDATA[Á.G.]]></given-names>
</name>
<name>
<surname><![CDATA[de la Rosa]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bustos-Jaimes]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Alvarez-Parrilla]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of &#945;-amylase by flavonoids: Structure activity relationship (SAR)]]></article-title>
<source><![CDATA[Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy]]></source>
<year>2019</year>
<volume>206</volume>
<page-range>437-47</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martinez-Gonzalez]]></surname>
<given-names><![CDATA[A.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Sánchez]]></surname>
<given-names><![CDATA[Á.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Vargas-Requena]]></surname>
<given-names><![CDATA[C.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Bustos-Jaimes]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Alvarez-Parrilla]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Polyphenolic compounds and digestive enzymes: In vitro non-covalent interactions]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2017</year>
<volume>22</volume>
<page-range>669</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miled]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Canaan]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Dupuis]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Roussel]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rivière]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Digestive lipases: from three-dimensional structure to physiology]]></article-title>
<source><![CDATA[Biochimie]]></source>
<year>2000</year>
<volume>82</volume>
<page-range>973-6</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pace]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Treviño]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Prabhakaran]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Scholtz]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Protein structure, stability and solubility in water and other solvents]]></article-title>
<source><![CDATA[Philosophical transactions of the Royal Society of London. Series B, Biological Sciences]]></source>
<year>2004</year>
<volume>359</volume>
<page-range>1225-35</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Plumb]]></surname>
<given-names><![CDATA[G.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Price]]></surname>
<given-names><![CDATA[K.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Williamson]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antioxidant properties of flavonol glycosides from tea]]></article-title>
<source><![CDATA[Redox Report]]></source>
<year>1999</year>
<volume>4</volume>
<page-range>13-6</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Proença]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - Activity relationship study]]></article-title>
<source><![CDATA[Food and Chemical Toxicology]]></source>
<year>2017</year>
<volume>111</volume>
<page-range>474-81</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rawel]]></surname>
<given-names><![CDATA[H.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rohn]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kruse]]></surname>
<given-names><![CDATA[H.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Kroll]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Structural changes induced in bovine serum albumin by covalent attachment of chlorogenic acid]]></article-title>
<source><![CDATA[Food Chemistry]]></source>
<year>2002</year>
<volume>78</volume>
<page-range>443-55</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proinflammatory pathways: The modulation by flavonoids]]></article-title>
<source><![CDATA[Medicinal Research Review]]></source>
<year>2015</year>
<volume>35</volume>
<page-range>877-936</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sakulnarmrat]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Konczak]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Composition of native Australian herbs polyphenolic-rich fractions and in vitro inhibitory activities against key enzymes relevant to metabolic syndrome]]></article-title>
<source><![CDATA[Food Chemistry]]></source>
<year>2012</year>
<volume>134</volume>
<page-range>1011-9</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tadera]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Minami]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Takamatsu]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of &#945;-glucosidase and &#945;-amylase by flavonoids]]></article-title>
<source><![CDATA[Journal of Nutritional Science and Vitaminology]]></source>
<year>2006</year>
<volume>52</volume>
<page-range>149-53</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tipton]]></surname>
<given-names><![CDATA[K.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Patterns of enzyme inhibition]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Engel]]></surname>
<given-names><![CDATA[P. C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Enzymology Labfax]]></source>
<year>1996</year>
<page-range>115-71</page-range><publisher-name><![CDATA[BIOS Scientific Publishers]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[van Tilbeurgh]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Bezzine]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Cambillau]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Verger]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Carrière]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Colipase: structure and interaction with pancreatic lipase]]></article-title>
<source><![CDATA[Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids]]></source>
<year>1999</year>
<volume>1441</volume>
<page-range>173-84</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zeng]]></surname>
<given-names><![CDATA[H.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Qu]]></surname>
<given-names><![CDATA[L.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular interactions of flavonoids to pepsin: Insights from spectroscopic and molecular docking studies]]></article-title>
<source><![CDATA[Spectrochimica Acta Part A: Molecular Biomolecular Spectros]]></source>
<year>2015</year>
<volume>151</volume>
<page-range>576-90</page-range></nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Deng]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Ramdath]]></surname>
<given-names><![CDATA[D.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Tang]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[P.X.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on &#945;-glucosidase and pancreatic lipase]]></article-title>
<source><![CDATA[Food Chemistry]]></source>
<year>2015</year>
<volume>172</volume>
<page-range>862-72</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lignin binding to pancreatic lipase and its influence on enzymatic activity]]></article-title>
<source><![CDATA[Food Chemistry]]></source>
<year>2014</year>
<volume>149</volume>
<page-range>99-106</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Jia]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenolic composition, antioxidant properties, and inhibition toward digestive enzymes with molecular docking Analysis of different fractions from Prinsepia utilis royle fruits]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2018</year>
<volume>23</volume>
<page-range>1-21</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
