<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462024000600368</article-id>
<article-id pub-id-type="doi">10.24875/bmhim.24000048</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Graft-versus-host disease variety toxic epidermal necrolysis. Case report]]></article-title>
<article-title xml:lang="es"><![CDATA[Enfermedad de injerto contra hospedero cutánea variedad necrólisis epidérmica toxica. Reporte de caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zúñiga-Lara]]></surname>
<given-names><![CDATA[Elsa M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zambrano-Virgen]]></surname>
<given-names><![CDATA[César M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaytán-Morales]]></surname>
<given-names><![CDATA[José F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza-Camargo]]></surname>
<given-names><![CDATA[Fredenet O.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Domínguez]]></surname>
<given-names><![CDATA[Yazmin A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Salud Hospital Infantil de México Federico Gómez Servicio de Pediatría]]></institution>
<addr-line><![CDATA[ Mexico City]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Servicio de Trasplante de células progenitoras hematopoyéticas ]]></institution>
<addr-line><![CDATA[ Mexico City]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>81</volume>
<numero>6</numero>
<fpage>368</fpage>
<lpage>371</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462024000600368&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462024000600368&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462024000600368&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: We present the case of a patient who underwent hematopoietic progenitor cell transplantation from a fully compatible unrelated donor and subsequently developed Grade IV skin graft-versus-host disease (GVHD) resembling toxic epidermal necrolysis (TEN).  Clinical case: An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD.  Conclusion: The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Se presenta el caso de paciente post trasplantado de células progenitoras hematopoyéticas de donador no relacionado 100% compatible con desarrollo de enfermedad, injerto contra hospedero cutánea grado IV tipo necrólisis epidérmica tóxica.  Caso clínico: Femenino de 11 años, post trasplantada de células progenitoras hematopoyéticas donador no relacionado 100% compatible realizada el 01.02.23, en su día +35 inicia con lesiones dérmicas exantemáticas en tronco y extremidades, biopsia de piel que reporta atrofia de dermis, vacuolización de la capa basal, queratinocitos apoptóticos confluentes con células inflamatorias mononucleares en dermoepidermis, confirmando así el diagnóstico de enfermedad injerto contra huésped cutánea tipo Necrólisis Epidérmica Tóxica.  Conclusión: Paciente presenta remisión de la sintomatología en un 80%, posterior al manejo dinámico de los inmunosupresores.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Toxic epidermal necrolysis]]></kwd>
<kwd lng="en"><![CDATA[Graft-versus-host disease]]></kwd>
<kwd lng="en"><![CDATA[Hematopoietic stem cell transplantation]]></kwd>
<kwd lng="es"><![CDATA[Necrólisis epidérmica tóxica]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad injerto contra huésped]]></kwd>
<kwd lng="es"><![CDATA[Trasplante de células progenitoras hematopoyéticas]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sheu Song]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Fraile Alonso]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Antaya]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Price]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
<name>
<surname><![CDATA[Funk]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxic epidermal necrolysis-like acute graft-versus-host disease in pediatric bone marrow transplant patients:case series and review of the literature]]></article-title>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2022</year>
<volume>39</volume>
<page-range>889-95</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vera]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Seminario-Vidal]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Graft-vs-host disease and toxic epidermal necrolysis following hematopoietic stem cell transplantation]]></article-title>
<source><![CDATA[Cutis]]></source>
<year>2022</year>
<volume>109</volume>
<page-range>12</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Klein]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kolm]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Nair]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Nägeli]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxic epidermal necrolysis-like acute cutaneous graft-versus-host disease in a stem cell recipient - a diagnostic dilemma]]></article-title>
<source><![CDATA[J Eur Acad Dermatol Venereol]]></source>
<year>2021</year>
<volume>35</volume>
<page-range>7</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goyal]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Delayed presentation of toxic epidermal necrolysis-like cutaneous acute graft-versus-host disease in the setting of recent immunosuppressant discontinuation]]></article-title>
<source><![CDATA[Dermatol Online J]]></source>
<year>2017</year>
<volume>23</volume>
<page-range>1-5</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jeanmonod]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hubbuch]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Grünhage]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Meiser]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rass]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Schilling]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Graft-versus-host disease or toxic epidermal necrolysis:diagnostic dilemma after liver transplantation]]></article-title>
<source><![CDATA[Transpl Infect Dis]]></source>
<year>2012</year>
<volume>14</volume>
<page-range>422-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
