1665-1146 1665-1146 S1665-11462022000400206 10.24875/bmhim.21000186 Mexico Mexico Mexico Mexico Mexico Mexico 00 08 2022 00 08 2022 79 4 206 214

1 2015 48 1063-72 2 2016 37 812-9 3 2019 178 1195-205 4 2019 9 a033258 5 World Health Organization 1991 6 2009 48 473-85 7 Global Burden of Disease (GBD) 2019 8 2019 97 725-8 9 1981 23 493-500 10 2019 20 288-98 11 2020 134 110043 12 2021 12 1277 13 2015 79 2295-9 14 2020 65 43-58 15 2022 141 785-803 16 2005 9 20-5 17 2004 130 541-6 18 Online Mendelian Inheritance in Man OMIM® 2021 19 2012 76 1678-80 20 2013 70 89-97 21 2014 78 2107-12 22 2014 78 1057-60 23 2016 18 364-71 24 2017 101 167-71 25 2020 40 635-43 26 1997 387 80-3 27 2011 32 81-7 28 2016 135 441-50 29 2016 28 705-12 30 2017 348 138-42 31 2020 41 194-207 32 2020 41 143-9 33 2020 9 228 34 2018 97 35 2011 77 573-6 36 2017 123 35-45 37 2020 10 258 38 2015 Toulouse, France