<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462021000500457</article-id>
<article-id pub-id-type="doi">10.24875/bmhim.20000353</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inhibidores de la aromatasa para estatura baja en niños y adolescentes de sexo masculino]]></article-title>
<article-title xml:lang="en"><![CDATA[Aromatase inhibitors for short stature in male children and adolescents]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barajas-Nava]]></surname>
<given-names><![CDATA[Leticia A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castilla-Peón]]></surname>
<given-names><![CDATA[M. Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Asociado Cochrane Unidad de Investigación de Medicina Basada en Evidencias ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Ediciones Médicas ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<volume>78</volume>
<numero>5</numero>
<fpage>457</fpage>
<lpage>460</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462021000500457&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462021000500457&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462021000500457&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Los inhibidores de la aromatasa son fármacos disponibles por vía oral que inhiben la conversión de la testosterona en estradiol. Los estrógenos desempeñan un papel esencial en la maduración del cartílago de crecimiento y del cierre epifisario, evento que marca el final del proceso de crecimiento esquelético. Por este motivo, los inhibidores de la aromatasa se han probado como una intervención para mejorar la talla en niños y adolescentes de sexo masculino mediante el retraso en la maduración esquelética al disminuir la concentración de estradiol en la placa de crecimiento. Se resumen los resultados de una revisión sistemática Cochrane en la cual se evaluaron la eficacia y la seguridad de los inhibidores de la aromatasa para el tratamiento de la estatura baja en niños.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Aromatase inhibitors are orally administered drugs that inhibit the conversion of testosterone to estradiol. Estrogens have an important role in growth plate maturation and epiphyseal closure. Thus, aromatase inhibitors have been used to improve final height in male children and adolescents by delaying skeletal maturation through a decrease in estradiol concentration. The results of a Cochrane systematic review evaluating the efficacy and safety of aromatase inhibitors for the treatment of short stature in children are summarized below.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Inhibidores de la aromatasa]]></kwd>
<kwd lng="es"><![CDATA[Niños varones]]></kwd>
<kwd lng="es"><![CDATA[Talla adulta]]></kwd>
<kwd lng="es"><![CDATA[Revisión sistemática]]></kwd>
<kwd lng="es"><![CDATA[Metaanálisis]]></kwd>
<kwd lng="en"><![CDATA[Aromatase inhibitors]]></kwd>
<kwd lng="en"><![CDATA[Male children]]></kwd>
<kwd lng="en"><![CDATA[Adult height]]></kwd>
<kwd lng="en"><![CDATA[Systematic review]]></kwd>
<kwd lng="en"><![CDATA[Meta-analysis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McGrath]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[O'Grady]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aromatase inhibitors for short stature in male children and adolescents]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2015</year>
<volume>8</volume>
<page-range>CD010888</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paltoglou]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Dimitropoulos]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Kourlaba]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Charmandari]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of treatment with recombinant human growth hormone (rhGH) on linear growth and adult height in children with idiopathic short stature (ISS):a systematic review and meta-analysis]]></article-title>
<source><![CDATA[J Pediatr Endocrinol Metab]]></source>
<year>2020</year>
<volume>33</volume>
<page-range>1577-88</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Deodati]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cianfarani]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of growth hormone therapy on adult height of children with idiopathic short stature:systematic review]]></article-title>
<source><![CDATA[BMJ]]></source>
<year>2011</year>
<volume>342</volume>
<page-range>c7157</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Higgins]]></surname>
<given-names><![CDATA[JPT]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]]]></article-title>
<source><![CDATA[The Cochrane Collaboration]]></source>
<year>2011</year>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="book">
<collab>The Nordic Cochrane Centre. The Cochrane Collaboration</collab>
<source><![CDATA[Review Manager (RevMan) Version 5.3]]></source>
<year>2014</year>
<publisher-loc><![CDATA[Copenhagen ]]></publisher-loc>
<publisher-name><![CDATA[The Nordic Cochrane Centre, The Cochrane Collaboration]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mauras]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ross]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Gagliardi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[YM]]></given-names>
</name>
<name>
<surname><![CDATA[Hossain]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Permuy]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature]]></article-title>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2016</year>
<volume>101</volume>
<page-range>4984-93</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
