<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462021000200152</article-id>
<article-id pub-id-type="doi">10.24875/bmhim.20000103</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dolor óseo generalizado e hipercalcemia en un lactante mayor como síntoma inicial de linfoma linfoblástico de células B]]></article-title>
<article-title xml:lang="en"><![CDATA[Generalized bone pain and hypercalcemia in an infant as an initial symptom of lymphoblastic lymphoma of B cells]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas-Gaspar]]></surname>
<given-names><![CDATA[Héctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán-Ladino]]></surname>
<given-names><![CDATA[Ivonne M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallegos-Gamboa]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velázquez-Isidro]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nevárez-Juárez]]></surname>
<given-names><![CDATA[Laura N.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zapata-Tarrés]]></surname>
<given-names><![CDATA[Marta M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Pediatría Servicio de Oncología Pediátrica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<volume>78</volume>
<numero>2</numero>
<fpage>152</fpage>
<lpage>158</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462021000200152&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462021000200152&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462021000200152&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Los linfomas no Hodgkin son neoplasias heterogéneas derivadas de las células linfohematopoyéticas. Es raro que se presenten antes de los 2 años de edad y la prevalencia es mayor en el sexo masculino.  Caso clínico: Paciente de sexo masculino de 1 año y 11 meses que debutó con dolor en miembros inferiores y superiores, claudicación intermitente, deformidad ósea e hipotonía generalizada, por lo que se sospechaba artritis juvenil. Se trató con antiinflamatorios no esteroideos. Al no haber mejoría, ingresó a otro hospital con adenopatías y nodulaciones en la región escrotal y braquial, y hepatomegalia, por lo que se presumió la activación precoz de la pubertad con evidencia de hipercalcemia. Los estudios radiológicos indicaron una posible displasia ósea. Sin embargo, la tomografía por emisión de positrones detectó zonas compatibles con un proceso maligno. Se diagnosticó linfoma de precursores B. La hipercalcemia es una alteración metabólica que, en presencia de cáncer, se considera un síndrome paraneoplásico. Es un dato clínico excepcional que se puede observar en niños con leucemia linfoblástica aguda.  Conclusiones: El dolor óseo en la edad pediátrica amerita una exploración física minuciosa para realizar un diagnóstico oportuno del cáncer infantil y mejorar el pronóstico del paciente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Non-Hodgkin lymphomas are heterogeneous neoplasms derived from lymphohematopoietic cells, which are rarely found in children &lt; 2 years of age and have a higher prevalence in males.  Case report: One-year and eleven-month-old male patient started with pain in the lower and upper limbs, intermittent claudication, bone deformity, and generalized hypotonia, for which juvenile arthritis was suspected. He received non-steroidal anti-inflammatory drug treatment. As no improvement was reported, he was admitted in a different hospital with lymph nodes and nodulations in the scrotal and brachial region and hepatomegaly. Therefore, early activation of puberty with evidence of hypercalcemia was presumed. Radiological studies indicated possible bone dysplasia; however, positron emission tomography detected areas compatible with malignant process. Precursor B lymphoma was diagnosed. Hypercalcemia is a metabolic disorder considered a paraneoplastic syndrome in the presence of cancer, which is an exceptional clinical finding in children with acute lymphoblastic leukemia.  Conclusions: Bone pain in the pediatric age deserves a thorough physical examination to favor an early diagnosis of childhood cancer and a better prognosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer pediátrico]]></kwd>
<kwd lng="es"><![CDATA[Dolor óseo]]></kwd>
<kwd lng="es"><![CDATA[Hipercalcemia]]></kwd>
<kwd lng="es"><![CDATA[Linfoma linfoblástico]]></kwd>
<kwd lng="en"><![CDATA[Pediatric cancer]]></kwd>
<kwd lng="en"><![CDATA[Bone pain]]></kwd>
<kwd lng="en"><![CDATA[Hypercalcemia]]></kwd>
<kwd lng="en"><![CDATA[Lymphoblastic lymphoma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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