<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2022000100313</article-id>
<article-id pub-id-type="doi">10.22201/fesz.23958723e.2022.502</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Introducción a los sistemas CRISPR y sus aplicaciones en levaduras]]></article-title>
<article-title xml:lang="en"><![CDATA[Introduction to CRISPR systems and their applications in yeasts]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza-Téllez]]></surname>
<given-names><![CDATA[Benjamín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zamora-Bello]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosas-Paz]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villarreal-Huerta]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fuente]]></surname>
<given-names><![CDATA[Ileana de la]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Segal-Kischinevzky]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[James]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Ciencias Departamento de Biología Celular]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>25</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2022000100313&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2022000100313&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2022000100313&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El sistema de inmunidad adaptativa en bacterias y arqueas, encargado de reconocer las secuencias de DNA invasores, se caracteriza por tener grupos de secuencias palindrómicas cortas repetidas e intercaladas de manera regular por espaciadores (CRISPR). Las proteínas asociadas a CRISPR (Cas) y los RNAs guías complementarios a secuencias específicas del DNA blanco constituyen una de las herramientas de edición genética más utilizadas para modificar a los organismos. En los últimos años se ha incrementado la variedad de los sistemas CRISPR/Cas, adaptándose a microorganismos como las levaduras, que cuentan con potencial biotecnológico. El objetivo de esta revisión es facilitar la comprensión de los conceptos básicos del sistema CRISPR/Cas9 y reconocer algunas de las variedades de esta herramienta molecular que se han implementado de manera exitosa en distintas levaduras. Asimismo, se describen varias de las nuevas tecnologías basadas en CRISPR que están revolucionando la investigación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The adaptive immunity system in bacteria and archaea, responsible for recognizing invasive DNA sequences, is characterized by clustered regularly interspaced short palindromic repeats (CRISPR). CRISPR-associated proteins (Cas) and guide RNAs complementary to specific target DNA sequences are the most widely used gene-editing tools to modify organisms. Currently, the variety of CRISPR/Cas systems has increased, adapting to microorganisms such as yeasts with biotechnological potential. This review aims to facilitate understanding of the basic concepts of the CRISPR/Cas9 system and to recognize some of the varieties of this molecular tool that have been successfully implemented in different yeasts. Likewise, some of the new technologies that are revolutionizing research based on CRISPR are described.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CRISPR]]></kwd>
<kwd lng="es"><![CDATA[Cas9]]></kwd>
<kwd lng="es"><![CDATA[edición genética]]></kwd>
<kwd lng="es"><![CDATA[levaduras]]></kwd>
<kwd lng="es"><![CDATA[ingeniería genética]]></kwd>
<kwd lng="es"><![CDATA[herramientas moleculares]]></kwd>
<kwd lng="en"><![CDATA[CRISPR]]></kwd>
<kwd lng="en"><![CDATA[Cas9]]></kwd>
<kwd lng="en"><![CDATA[gene-editing]]></kwd>
<kwd lng="en"><![CDATA[yeasts]]></kwd>
<kwd lng="en"><![CDATA[genetic engineering]]></kwd>
<kwd lng="en"><![CDATA[molecular tools]]></kwd>
</kwd-group>
</article-meta>
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