<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2022000100306</article-id>
<article-id pub-id-type="doi">10.22201/fesz.23958723e.2022.450</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Uso de la inteligencia artificial en la investigación para el reposicionamiento de fármacos]]></article-title>
<article-title xml:lang="en"><![CDATA[Artificial intelligence in drug repurposing research]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olascoaga-Del Angel]]></surname>
<given-names><![CDATA[Kevin Samael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Konigsberg-Fainstein]]></surname>
<given-names><![CDATA[Mina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Villanueva]]></surname>
<given-names><![CDATA[Jaime]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Díaz-Guerrero]]></surname>
<given-names><![CDATA[Norma Edith]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma Metropolitana Iztapalapa DCBS Posgrado en Biología Experimental]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma Metropolitana Departamento de Ciencias de la Salud Laboratorio de Bioenergética y Envejecimiento Celular]]></institution>
<addr-line><![CDATA[Iztapalapa ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma Metropolitana División de Ciencias Biológicas y de la Salud Departamento de Sistemas Biológicos]]></institution>
<addr-line><![CDATA[Xochimilco ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>25</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2022000100306&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2022000100306&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2022000100306&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El desarrollo de algoritmos para su utilización en la inteligencia artificial y la disponibilidad masiva de datos biomédicos han impulsado y acelerado la investigación, con el resultado de descubrimientos y de tratamientos novedosos utilizando fármacos patentados y aprobados para el tratamiento de diferentes enfermedades. Este proceso se conoce como reposicionamiento de fármacos (REFA), y puede ser abordado por una rama de la inteligencia artificial (IA) conocida como aprendizaje automático (AA). El aprendizaje automático se basa en un conjunto de algoritmos que, combinados con técnicas computacionales bien establecidas en el campo del descubrimiento de fármacos, han sido capaces de dar lugar, con una alta eficacia, a nuevas propiedades y relaciones farmacológicas anteriormente desconocidas. Así, se han identificado nuevos blancos y tratamientos potenciales contra diversos padecimientos como el cáncer, y las enfermedades neurodegenerativas e infecciosas, entre otras. El objetivo de este trabajo de revisión es contribuir a la literatura en español sobre el uso de la inteligencia artificial y el aprendizaje de máquina en la investigación para el reposicionamiento de fármacos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The development of sophisticated artificial intelligence algorithms and the massive availability of biomedical data have driven accelerated research to discover novel treatments using drugs previously developed and approved for other uses. This process is known as drug repositioning (DR), and it can be addressed by a branch of artificial intelligence (AI) known as machine learning (ML). Machine learning is based on a set of algorithms that, combined with well-established computational techniques in the field of drug discovery, have been able to infer new previously unknown pharmacological properties and relationships with high efficiency. Thus, new targets and potential treatments against various diseases such as cancer and neurodegenerative and infectious diseases have been identified. The objective of this review is to contribute to the literature in Spanish on the use of Artificial Intelligence and machine learning in drug repositioning research.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[reposicionamiento de fármacos]]></kwd>
<kwd lng="es"><![CDATA[inteligencia artificial]]></kwd>
<kwd lng="es"><![CDATA[descubrimiento de fármacos]]></kwd>
<kwd lng="es"><![CDATA[aprendizaje automático]]></kwd>
<kwd lng="es"><![CDATA[quimioinformática]]></kwd>
<kwd lng="en"><![CDATA[drug repurposing]]></kwd>
<kwd lng="en"><![CDATA[artificial intelligence]]></kwd>
<kwd lng="en"><![CDATA[drug discovery]]></kwd>
<kwd lng="en"><![CDATA[machine learning]]></kwd>
<kwd lng="en"><![CDATA[chemoinformatics]]></kwd>
</kwd-group>
</article-meta>
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