<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2015000200144</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Infertilidad masculina y fragmentación del ADN espermático: Un problema actual]]></article-title>
<article-title xml:lang="en"><![CDATA[Male infertility and spermatic DNA fragmentation: A current problem]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero-Vásquez]]></surname>
<given-names><![CDATA[Gabriela Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermúdez-Cruz]]></surname>
<given-names><![CDATA[Rosa María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo-Cadena]]></surname>
<given-names><![CDATA[Julieta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma del Estado de México Centro de Investigación en Ciencias Médicas ]]></institution>
<addr-line><![CDATA[Toluca ]]></addr-line>
<country>MX</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Mexico CINVESTAV Departamento de Genética y Biología Molecular]]></institution>
<addr-line><![CDATA[México D.F]]></addr-line>
<country>MX</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2015</year>
</pub-date>
<volume>18</volume>
<numero>2</numero>
<fpage>144</fpage>
<lpage>151</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2015000200144&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2015000200144&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2015000200144&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[El ADN del espermatozoide aporta la mitad del material genético a la descendencia, en la actualidad los parámetros obtenidos a través de un seminograma no dan una información completa sobre el potencial fecundante del semen y la capacidad de dar lugar a un embrión sano y un embarazo evolutivo. Es por ésto que ha aumentado el interés en desarrollar técnicas encaminadas a evaluar la fragmentación del ADN espermático, ya que en cualquier etapa del proceso de la espermatogénesis se puede producir un daño, siendo éste un fenómeno multifactorial y no del todo delimitado. Actualmente la infertilidad es un problema global que va en aumento y se ha demostrado que la calidad del ADN del espermatozoide puede afectar la fecundación; es por ello que la evaluación de la integridad del ADN, además del estudio de los parámetros seminales, puede aportar información adicional acerca de la calidad del espermatozoide, y ser de gran ayuda para identificar las causas de la infertilidad masculina y así orientar de mejor manera a las parejas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Spermatic DNA contributes one half of the genetic material to offspring. Currently, the parameters obtained through a seminogram do not provide complete information on the potential fertilization of the semen and the ability to produce a healthy embryo and an on-going pregnancy. This is the reason why the interest in developing techniques to assess sperm DNA fragmentation has been increased, as damage during spermatogenesis can occur at any stage of the process, this being a multifactorial phenomenon and not entirely delimited yet. Nowadays the infertility is an increasing global problem, and it has been shown that the quality of the DNA in the sperm can affect fertilization; this is why the evaluation of sperm DNA integrity, in addition to the study of the sperm parameters may provide additional information on the quality of the spermatozoa, resulting in great help to identify the causes of male infertility and thus can be used to better guide couples with infertility issues.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ADN espermático]]></kwd>
<kwd lng="es"><![CDATA[calidad del espermatozoide]]></kwd>
<kwd lng="es"><![CDATA[fragmentación del ADN]]></kwd>
<kwd lng="es"><![CDATA[infertilidad]]></kwd>
<kwd lng="es"><![CDATA[semen]]></kwd>
<kwd lng="en"><![CDATA[spermatic DNA]]></kwd>
<kwd lng="en"><![CDATA[sperm quality]]></kwd>
<kwd lng="en"><![CDATA[DNA fragmentation]]></kwd>
<kwd lng="en"><![CDATA[infertility]]></kwd>
<kwd lng="en"><![CDATA[semen]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<collab>WHO</collab>
<source><![CDATA[Biomarkers and Risk Assessment: Concepts and Principle]]></source>
<year>1990</year>
<publisher-name><![CDATA[World Health Organization]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Significance of sperm characteristics in the evaluation of male infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nallella]]></surname>
<given-names><![CDATA[K.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[R.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Aziz]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2006</year>
<volume>85</volume>
<page-range>629-34</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="">
<article-title xml:lang=""><![CDATA[Sperm density and environment]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spira]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Multigner]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Treatment of infertility: the new frotiers]]></source>
<year>1998</year>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Infertile men older than 40 years are at higher risk of sperm DNA damage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alshahrani]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Reprod. Biol. Endocrinol.]]></source>
<year>2014</year>
<volume>12</volume>
<page-range>103</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Enciso]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Alfarawati]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Wells]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>2013</year>
<volume>28</volume>
<page-range>1707-15</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gallegos]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2008</year>
<volume>90</volume>
<page-range>328-34</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cigarette smoking affects sperm plasma membrane integrity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[W.W.]]></given-names>
</name>
</person-group>
<source><![CDATA[Zhonghua Nan Ke Xue]]></source>
<year>2013</year>
<volume>18</volume>
<page-range>1093-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of alcohol and cigarette consumption on human seminal quality]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martini]]></surname>
<given-names><![CDATA[A.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2004</year>
<volume>82</volume>
<page-range>374-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Organophosphorous pesticide exposure alters sperm chromatin structure in Mexican agricultural workers]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez-Peña]]></surname>
<given-names><![CDATA[L.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Toxicol. Appl. Pharmacol.]]></source>
<year>2004</year>
<volume>196</volume>
<page-range>108-13</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Elemental composition of human semen is associated with motility and genomic sperm defects among older men]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schmid]]></surname>
<given-names><![CDATA[T.E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>2013</year>
<volume>28</volume>
<page-range>274-82</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menkveld]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The basic semen analysis. Chapter 9]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Oehninger]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kruger]]></surname>
<given-names><![CDATA[T.F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Male Infertility. Diagnosis and treatment]]></source>
<year>2007</year>
<page-range>141-70</page-range><publisher-loc><![CDATA[Oxon, UK ]]></publisher-loc>
<publisher-name><![CDATA[Informa Healthcare]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Semen analysis: its place in modern reproductive medical practice]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[McLachlan]]></surname>
<given-names><![CDATA[R.I.]]></given-names>
</name>
</person-group>
<source><![CDATA[Pathology]]></source>
<year>2003</year>
<volume>35</volume>
<page-range>25-33</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="book">
<collab>WHO</collab>
<source><![CDATA[Laboratory Manual for the examination and Processing of Human Semen]]></source>
<year>2010</year>
<edition>5th</edition>
<publisher-name><![CDATA[World Health Organization press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Human semen analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Comhaire]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Vermeulen]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum Reprod Update]]></source>
<year>1995</year>
<volume>1</volume>
<page-range>343-62</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cocuzza]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Int. Braz. J. Urol.]]></source>
<year>2010</year>
<volume>41</volume>
<page-range>181-3</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Special interest group for andrology basic semen analysis course: a continued focus on accuracy, quality, efficiency and clinical relevance]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barratt]]></surname>
<given-names><![CDATA[C.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Bjorndahl]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Menkveld]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mortimer]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>2011</year>
<volume>26</volume>
<page-range>3207-12</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Efficacy of treatment for unexplained infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guzick]]></surname>
<given-names><![CDATA[D.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil. Steril.]]></source>
<year>1998</year>
<volume>70</volume>
<page-range>207-13</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carrell]]></surname>
<given-names><![CDATA[D.T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Arch. Androl.]]></source>
<year>2003</year>
<volume>49</volume>
<page-range>49-55</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA fragmentation in couples with unexplained recurrent spontaneous abortions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khadem]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Poorhoseyni]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Jalali]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Akbary]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Heydari]]></surname>
<given-names><![CDATA[S.T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Andrologia]]></source>
<year>2014</year>
<volume>46</volume>
<page-range>126-30</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fragmentation of DNA affects the accuracy of the DNA quantitation by the commonly used methods]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sedlackova]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Repiska]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Celec]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Szemes]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Minarik]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biol. Proced. Online]]></source>
<year>2013</year>
<volume>15</volume>
<page-range>5</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[DNA integrity in human spermatozoa: relationships with semen quality]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Irvine]]></surname>
<given-names><![CDATA[D.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Androl.]]></source>
<year>2000</year>
<volume>21</volume>
<page-range>33-44</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Spermatogenesis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Kretser]]></surname>
<given-names><![CDATA[D.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Loveland]]></surname>
<given-names><![CDATA[K.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Meinhardt]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Simorangkir]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Wreford]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>1998</year>
<volume>13</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epigenetics, spermatogenesis and male infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rajender]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Avery]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mutat. Res.]]></source>
<year>2011</year>
<volume>727</volume>
<page-range>62-71</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Human spermatogenesis in vitro: respective effects of follicle-stimulating hormone and testosterone on meiosis, spermiogenesis, and Sertoli cell apoptosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tesarik]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Guido]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Greco]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Clin. Endocrinol. Metab.]]></source>
<year>1998</year>
<volume>83</volume>
<page-range>4467-73</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[DNA integrity is compromised in protamine-deficient human sperm]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aoki]]></surname>
<given-names><![CDATA[V.W.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Androl.]]></source>
<year>2005</year>
<volume>26</volume>
<page-range>741-8</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The protamine family of sperm nuclear proteins]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balhorn]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Genome Biol.]]></source>
<year>2007</year>
<volume>8</volume>
<page-range>227</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Altered protamine expression and diminished spermatogenesis: what is the link?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carrell]]></surname>
<given-names><![CDATA[D.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Emery]]></surname>
<given-names><![CDATA[B.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Hammoud]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod. Update]]></source>
<year>2007</year>
<volume>13</volume>
<page-range>313-27</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The effects of protamine deficiency on ultrastructure of human sperm nucleus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Iranpour]]></surname>
<given-names><![CDATA[F.G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Adv. Biomed. Res.]]></source>
<year>2014</year>
<volume>3</volume>
<page-range>24</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Protamine alterations in human spermatozoa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jodar]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Oliva]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Adv. Exp. Med. Biol.]]></source>
<year>2013</year>
<volume>791</volume>
<page-range>83-102</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Protamine extraction and analysis of human sperm protamine 1/protamine 2 ratio using Acid gel electrophoresis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Aston]]></surname>
<given-names><![CDATA[K.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Carrell]]></surname>
<given-names><![CDATA[D.T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Methods Mol. Biol.]]></source>
<year></year>
<volume>927</volume>
<page-range>445-50</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm chromatin integrity: etiologies and mechanisms of abnormality, assays, clinical importance, preventing and repairing damage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hekmatdoost]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Lakpour]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Sadeghi]]></surname>
<given-names><![CDATA[M.R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Avicenna J. Med. Biotechnol.]]></source>
<year>2009</year>
<volume>1</volume>
<page-range>147-60</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Role of sperm chromatin abnormalities and DNA damage in male infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Said]]></surname>
<given-names><![CDATA[T.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod. Update]]></source>
<year>2003</year>
<volume>9</volume>
<page-range>331-45</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2013</year>
<volume>101</volume>
<page-range>51-7</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Utility of oxidative stress test in the male infertility clinic]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Saleh]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Zhonghua Nan Ke Xue]]></source>
<year>2002</year>
<volume>8</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Contribution of enviromental factors to the risk of male infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oliva A.]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Multigner]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod]]></source>
<year>2011</year>
<volume>16</volume>
<page-range>1768-76</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environment]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Godmann]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lambrot]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kimmins]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Microsc. Res. Tech.]]></source>
<year>2009</year>
<volume>72</volume>
<page-range>603-19</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Testicular size, morphology and spermatogenesis in infertile males with varicocele]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Sikka]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Dev]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Banerjee]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Indian J. Pathol. Microbiol.]]></source>
<year>1988</year>
<volume>31</volume>
<page-range>19-25</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Milne]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Leeson]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Reprod. Biomed. Online]]></source>
<year>2014</year>
<volume>28</volume>
<page-range>684-703</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oxidative stress, DNA damage and the Y chromosome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aitken]]></surname>
<given-names><![CDATA[R.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Krausz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Reproduction]]></source>
<year>2001</year>
<volume>122</volume>
<page-range>497-506</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA damage assessment: a test whose time has come]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Allamaneni]]></surname>
<given-names><![CDATA[S.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2005</year>
<volume>84</volume>
<page-range>850-3</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA damage and male infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koskimies]]></surname>
<given-names><![CDATA[A.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Savander]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ann-Marie]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Kurunmaki]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Duodecim.]]></source>
<year>2011</year>
<volume>126</volume>
<page-range>2837-42</page-range></nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zini]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bielecki]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Phang]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Zenzes]]></surname>
<given-names><![CDATA[M.T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2001</year>
<volume>75</volume>
<page-range>674-7</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The effects of different sperm preparation methods and incubation time on the sperm DNA fragmentation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[X.D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Fertil (Camb.)]]></source>
<year>2011</year>
<volume>14</volume>
<page-range>187-91</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[DNA status on thawed semen from fighting bull: a comparison between the SCD and the SCSA tests]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-Pastor]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández-Santos]]></surname>
<given-names><![CDATA[M.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Domínguez-Rebolledo]]></surname>
<given-names><![CDATA[A.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Esteso]]></surname>
<given-names><![CDATA[M.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Garde]]></surname>
<given-names><![CDATA[J.J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Reprod. Domest. Anim.]]></source>
<year>2009</year>
<volume>44</volume>
<page-range>424-31</page-range></nlm-citation>
</ref>
<ref id="B45">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comprehensive analysis of sperm DNA fragmentation by five different assays: TUNEL assay, SCSA, SCD test and alkaline and neutral Comet assay]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ribas-Maynou]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Andrology]]></source>
<year>2013</year>
<volume>1</volume>
<page-range>715-22</page-range></nlm-citation>
</ref>
<ref id="B46">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[COMET, TUNEL, and TEM analysis of an infertile male with short tail sperm]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durmaz]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Turk. Ger. Gynecol. Assoc.]]></source>
<year>2015</year>
<volume>16</volume>
<page-range>54-7</page-range></nlm-citation>
</ref>
<ref id="B47">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fragmentation of sperm DNA using the TUNEL method]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chenlo]]></surname>
<given-names><![CDATA[P.H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Actas Urol. Esp.]]></source>
<year>2014</year>
<volume>38</volume>
<page-range>608-12</page-range></nlm-citation>
</ref>
<ref id="B48">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Flow cytometry TUNEL standardization for assaying sperm DNA fragmentation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Curi]]></surname>
<given-names><![CDATA[S.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Androl.]]></source>
<year>2011</year>
<volume>33</volume>
<page-range>1</page-range></nlm-citation>
</ref>
<ref id="B49">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Human sperm DNA fragmentation: correlation of TUNEL results as assessed by flow cytometry and optical microscopy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Domínguez-Fandos]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Camejo]]></surname>
<given-names><![CDATA[M.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Ballesca]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Oliva]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cytometry A.]]></source>
<year>2007</year>
<volume>71</volume>
<page-range>1011-8</page-range></nlm-citation>
</ref>
<ref id="B50">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Detection of DNA damage in tissue sections by in situ nick translation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chesselet]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
<name>
<surname><![CDATA[MacKenzie]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Hoang]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr. Protoc. Neurosci.]]></source>
<year>2001</year>
<volume>19</volume>
</nlm-citation>
</ref>
<ref id="B51">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gorczyca]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Gong]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Darzynkiewicz]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer Res.]]></source>
<year>1993</year>
<volume>53</volume>
<page-range>1945-51</page-range></nlm-citation>
</ref>
<ref id="B52">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Susceptibility of human sperm to in situ DNA denaturation is strongly correlated with DNA strand breaks identified by single-cell electrophoresis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aravindan]]></surname>
<given-names><![CDATA[G.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Bjordahl]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Jost]]></surname>
<given-names><![CDATA[L.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Evenson]]></surname>
<given-names><![CDATA[D.P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Exp. Cell Res.]]></source>
<year>1997</year>
<volume>236</volume>
<page-range>231-7</page-range></nlm-citation>
</ref>
<ref id="B53">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The comet assay: a comprehensive review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fairbairn]]></surname>
<given-names><![CDATA[D.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Olive]]></surname>
<given-names><![CDATA[P.L.]]></given-names>
</name>
<name>
<surname><![CDATA[O'Neill]]></surname>
<given-names><![CDATA[K.L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mutat. Res.]]></source>
<year>1995</year>
<volume>339</volume>
<page-range>37-59</page-range></nlm-citation>
</ref>
<ref id="B54">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bungum]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Bungum]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Giwercman]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Asian J. Androl.]]></source>
<year>2011</year>
<volume>13</volume>
<page-range>69-75</page-range></nlm-citation>
</ref>
<ref id="B55">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm chromatin structure assay (SCSA)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Evenson]]></surname>
<given-names><![CDATA[D.P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Methods Mol. Biol.]]></source>
<year>2012</year>
<volume>927</volume>
<page-range>147-64</page-range></nlm-citation>
</ref>
<ref id="B56">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparison of the Halosperm test kit with the sperm chromatin structure assay (SCSA) infertility test in relation to patient diagnosis and prognosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Evenson]]></surname>
<given-names><![CDATA[D.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Wixon]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2005</year>
<volume>84</volume>
<page-range>846-9</page-range></nlm-citation>
</ref>
<ref id="B57">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[TUNEL assay and SCSA determine different aspects of sperm DNA damage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Henkel]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Hoogendijk]]></surname>
<given-names><![CDATA[C.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Bouic]]></surname>
<given-names><![CDATA[P.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Kruger]]></surname>
<given-names><![CDATA[T.F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Andrologia]]></source>
<year>2010</year>
<volume>42</volume>
<page-range>305-13</page-range></nlm-citation>
</ref>
<ref id="B58">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2005</year>
<volume>84</volume>
<page-range>833-42</page-range></nlm-citation>
</ref>
<ref id="B59">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Androl.]]></source>
<year>2003</year>
<volume>24</volume>
<page-range>59-66</page-range></nlm-citation>
</ref>
<ref id="B60">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Increased aneuploidy rate in sperm with fragmented DNA as determined by the sperm chromatin dispersion (SCD) test and FISH analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muriel]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Androl.]]></source>
<year>2007</year>
<volume>28</volume>
<page-range>38-49</page-range></nlm-citation>
</ref>
<ref id="B61">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fertilizing ability of DNA-damaged spermatozoa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahmadi]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ng]]></surname>
<given-names><![CDATA[S.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Exp. Zool.]]></source>
<year>1999</year>
<volume>284</volume>
<page-range>696-704</page-range></nlm-citation>
</ref>
<ref id="B62">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Developmental capacity of damaged spermatozoa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahmadi]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ng]]></surname>
<given-names><![CDATA[S.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>1999</year>
<volume>14</volume>
<page-range>2279-85</page-range></nlm-citation>
</ref>
<ref id="B63">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The significance of sperm nuclear DNA strand breaks on reproductive outcome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spano]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Seli]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Bizzaro]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Manicardi]]></surname>
<given-names><![CDATA[G.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Sakkas]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr. Opin. Obstet. Gynecol.]]></source>
<year>2005</year>
<volume>17</volume>
<page-range>255-60</page-range></nlm-citation>
</ref>
<ref id="B64">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wossidlo]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[EMBO. J.]]></source>
<year>2010</year>
<volume>29</volume>
<page-range>1877-88</page-range></nlm-citation>
</ref>
<ref id="B65">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The ability of sperm selection techniques to remove single- or double-strand DNA damage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Enciso]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Asian J. Androl.]]></source>
<year>2011</year>
<volume>13</volume>
<page-range>764-8</page-range></nlm-citation>
</ref>
<ref id="B66">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Derijck]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[van der Heijden]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Giele]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Philippens]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[de Boer]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Mol. Genet.]]></source>
<year>2008</year>
<volume>17</volume>
<page-range>1922-37</page-range></nlm-citation>
</ref>
<ref id="B67">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm morphological abnormalities as indicators of DNA fragmentation and fertilization in ICSI]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Daris]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Goropevsek]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hojnik]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Vlaisavljevic]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<source><![CDATA[Arch. Gynecol. Obstet.]]></source>
<year>2009</year>
<volume>281</volume>
<page-range>363-7</page-range></nlm-citation>
</ref>
<ref id="B68">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frydman]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2008</year>
<volume>89</volume>
<page-range>92-7</page-range></nlm-citation>
</ref>
<ref id="B69">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm chromatin structure correlates with spontaneous abortion and multiple pregnancy rates in assisted reproduction]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kennedy]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Ahlering]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Sutovsky]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Reprod. Biomed. Online]]></source>
<year>2011</year>
<volume>22</volume>
<page-range>272-6</page-range></nlm-citation>
</ref>
<ref id="B70">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2008</year>
<volume>90</volume>
<page-range>352-9</page-range></nlm-citation>
</ref>
<ref id="B71">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lutton]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[McManus]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[S.E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2010</year>
<volume>95</volume>
<page-range>652-7</page-range></nlm-citation>
</ref>
<ref id="B72">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[An algorithm to predict pregnancy in assisted reproduction]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[S.E.]]></given-names>
</name>
<name>
<surname><![CDATA[O'Connell]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Stevenson]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Thompson-Cree]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[McClure]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>2004</year>
<volume>19</volume>
<page-range>1385-94</page-range></nlm-citation>
</ref>
<ref id="B73">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Redefining the relationship between sperm deoxyribonucleic acid fragmentation as measured by the sperm chromatin structure assay and outcomes of assisted reproductive techniques]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Payne]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2005</year>
<volume>84</volume>
<page-range>356-64</page-range></nlm-citation>
</ref>
<ref id="B74">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fujimoto]]></surname>
<given-names><![CDATA[V.Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Browne]]></surname>
<given-names><![CDATA[R.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Bloom]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Sakkas]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Alikani]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year></year>
<volume>95</volume>
<page-range>1197-204</page-range></nlm-citation>
</ref>
<ref id="B75">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Mitochondrial DNA content in embryo culture medium is significantly associated with human embryo fragmentation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stigliani]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Anserini]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Venturini]]></surname>
<given-names><![CDATA[P.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Scaruffi]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum. Reprod.]]></source>
<year>2013</year>
<volume>28</volume>
<page-range>2652-60</page-range></nlm-citation>
</ref>
<ref id="B76">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Are sperm DNA fragmentation, hyperactivation, and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization and intracytoplasmic sperm injection?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pregl Breznik]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Kovacic]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Vlaisavljevic]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2013</year>
<volume>99</volume>
<page-range>1233-41</page-range></nlm-citation>
</ref>
<ref id="B77">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Origin of DNA damage in ejaculated human spermatozoa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sakkas]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev. Reprod.]]></source>
<year>1999</year>
<volume>4</volume>
<page-range>31-7</page-range></nlm-citation>
</ref>
<ref id="B78">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muratori]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Med.]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B79">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Seminal parameters at different times of reanalysis of the normal semen samples detected in initial examination and their correlation with sperm DNA damage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Zhonghua Nan Ke Xue]]></source>
<year>2013</year>
<volume>19</volume>
<page-range>63-7</page-range></nlm-citation>
</ref>
<ref id="B80">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA fragmentation: awakening the sleeping genome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shaman]]></surname>
<given-names><![CDATA[J.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Yamauchi]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Ward]]></surname>
<given-names><![CDATA[W.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. Soc. Trans.]]></source>
<year>2007</year>
<volume>35</volume>
<page-range>626-8</page-range></nlm-citation>
</ref>
<ref id="B81">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA tests as useful adjuncts to semen analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[S.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Agbaje]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Syst. Biol. Reprod. Med.]]></source>
<year>2008</year>
<volume>54</volume>
<page-range>111-25</page-range></nlm-citation>
</ref>
<ref id="B82">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[J.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Jurisicova]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Meriano]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Casper]]></surname>
<given-names><![CDATA[R.F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>1998</year>
<volume>69</volume>
<page-range>528-32</page-range></nlm-citation>
</ref>
<ref id="B83">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[J.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Jurisicova]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Casper]]></surname>
<given-names><![CDATA[R.F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biol. Reprod.]]></source>
<year>1997</year>
<volume>56</volume>
<page-range>602-7</page-range></nlm-citation>
</ref>
<ref id="B84">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sperm DNA fragmentation negatively correlates with velocity and fertilization rates but might not affect pregnancy rates]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fertil Steril]]></source>
<year>2005</year>
<volume>84</volume>
<page-range>130-40</page-range></nlm-citation>
</ref>
<ref id="B85">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Are we ready to incorporate sperm DNA-fragmentation testing into our male infertility work-up?. A plea for more robust studies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Drobnis]]></surname>
<given-names><![CDATA[E.Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Reprod. Biomed.]]></source>
<year>2015</year>
<volume>30</volume>
<page-range>111-2</page-range></nlm-citation>
</ref>
<ref id="B86">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Human sperm DNA fragmentation and its correlation with conventional semen parameters]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Evgeni]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Charalabopoulos]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Asimakopoulos]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Reprod. Infertil]]></source>
<year>2014</year>
<volume>15</volume>
<page-range>2-14</page-range></nlm-citation>
</ref>
<ref id="B87">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Are sperm chromatin and DNA defects relevant in the clinic?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zini]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Syst. Biol. Reprod. Med.]]></source>
<year>2011</year>
<volume>57</volume>
<page-range>78-85</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
