<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2015000200131</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Receptores nucleares: del núcleo al citoplasma]]></article-title>
<article-title xml:lang="en"><![CDATA[Nuclear receptors: from the nucleus to the cytoplasm]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega-Domínguez]]></surname>
<given-names><![CDATA[Bibiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera-Ramírez]]></surname>
<given-names><![CDATA[Marlene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tecalco-Cruz]]></surname>
<given-names><![CDATA[Angeles C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Investigaciones Biomédicas Departamento de Biología Molecular y Biotecnología]]></institution>
<addr-line><![CDATA[México D.F.]]></addr-line>
<country>MX</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2015</year>
</pub-date>
<volume>18</volume>
<numero>2</numero>
<fpage>131</fpage>
<lpage>143</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2015000200131&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2015000200131&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2015000200131&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Los receptores nucleares (RNs) constituyen una familia de factores transcripcionales activados por ligando que regulan la expresión de un gran número de genes de forma dependiente del tipo y contexto celular. La localización subcelular de los RNs es altamente dinámica y repercute sobre sus funciones como factores transcripcionales. En presencia de su ligando específico, los RNs se acumulan en el núcleo para modular la expresión de sus genes blanco. Por ende, la salida desde el núcleo a citoplasma de los RNs disminuye su acumulación nuclear y abate su actividad transcripcional. Por lo tanto, la exportación nuclear constituye un importante mecanismo de regulación de la actividad de los RNs. A pesar de su importancia, el proceso de exportación nuclear de los RNs no ha sido completamente explorado, sin embargo, los estudios que se tienen hasta ahora sugieren la participación de las proteínas CRM-1 y la Calreticulina (CRT) como mediadoras de este proceso. En esta revisión se destaca la exportación nuclear como un mecanismo regulador de las funciones de los RNs y se discuten las características estructurales y funcionales de las exportinas CRM-1 y CRT.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Nuclear receptors (RNs) are a family of transcription factors activated by ligand which regulate the expression of many genes dependent on the cellular type and context. The subcellular localization of RNs is highly dynamic and affects its function as transcriptional factors. In the presence of its specific ligand, the RNs increase in the nucleus to modulate the expression of their target genes. Thus, the exit from nucleus to cytoplasm of RNs decreases its nuclear accumulation and its transcriptional activity. Therefore, nuclear export is an important mechanism regulating the activity of RNs. Despite its importance, the process of nuclear export of RNs has not been fully studied. However, the studies made so far suggest the involvement of the CRM-1 and Calreticulin (CRT) proteins as mediators of this process. In this review, we highlight the nuclear export as a regulatory mechanism to control the functions of RNs and the structural and functional characteristics of CRM-1 and CRT exportins are discussed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CRM&#8211;1]]></kwd>
<kwd lng="es"><![CDATA[CRT]]></kwd>
<kwd lng="es"><![CDATA[exportación nuclear]]></kwd>
<kwd lng="es"><![CDATA[receptores nucleares]]></kwd>
<kwd lng="es"><![CDATA[regulación transcripcional]]></kwd>
<kwd lng="en"><![CDATA[CRM&#8211;1]]></kwd>
<kwd lng="en"><![CDATA[CRT]]></kwd>
<kwd lng="en"><![CDATA[nuclear export]]></kwd>
<kwd lng="en"><![CDATA[nuclear receptors]]></kwd>
<kwd lng="en"><![CDATA[transcriptional regulation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Overview of nomenclature of nuclear receptors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Germain]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Pharmacol. Rev.]]></source>
<year>2006</year>
<volume>58</volume>
<page-range>685-704</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear receptors: decoding metabolic disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sonoda]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Pei]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Evans]]></surname>
<given-names><![CDATA[R.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[FEBS Lett.]]></source>
<year>2008</year>
<volume>582</volume>
<page-range>2-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear receptor coregulators: modulators of pathology and therapeutic targets]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lonard]]></surname>
<given-names><![CDATA[D.M.]]></given-names>
</name>
<name>
<surname><![CDATA[O'Malley]]></surname>
<given-names><![CDATA[B.W.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat. Rev. Endocrinol.]]></source>
<year>2012</year>
<volume>8</volume>
<page-range>598-604</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roshan-Moniri]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer Treat. Rev.]]></source>
<year>2014</year>
<volume>40</volume>
<page-range>1137-52</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear receptors and pathogenesis of pancreatic cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Polvani]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[World J. Gastroenterol.]]></source>
<year>2014</year>
<volume>20</volume>
<page-range>12062-81</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[General molecular biology and architecture of nuclear receptors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pawlak]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lefebvre]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Staels]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr. Top. Med. Chem.]]></source>
<year>2012</year>
<volume>12</volume>
<page-range>486-504</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Signalling through nuclear receptors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tata]]></surname>
<given-names><![CDATA[J.R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat. Rev. Mol. Cell Biol.]]></source>
<year>2002</year>
<volume>3</volume>
<page-range>702-10</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear receptors and their selective pharmacologic modulators]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burris]]></surname>
<given-names><![CDATA[T.P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Pharmacol. Rev.]]></source>
<year>2013</year>
<volume>65</volume>
<page-range>710-78</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Signaling by nuclear receptors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sever]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Glass]]></surname>
<given-names><![CDATA[C.K.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cold. Spring. Harb. Perspect. Biol.]]></source>
<year>2013</year>
<volume>5</volume>
<page-range>a016709</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Cao]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Int. J. Mol. Sci.]]></source>
<year>2015</year>
<volume>15</volume>
<page-range>15412-25</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nongenomic actions of steroid hormones]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Losel]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Wehling]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat. Rev. Mol. Cell Biol.]]></source>
<year>2003</year>
<volume>4</volume>
<page-range>46-56</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ligand-induced estrogen receptor alpha degradation by the proteasome: new actors?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Callige]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Richard-Foy]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucl. Recept. Signal.]]></source>
<year>2006</year>
<volume>4</volume>
<page-range>e004</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[MUC1 oncoprotein stabilizes and activates estrogen receptor alpha]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kufe]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Cell]]></source>
<year>2006</year>
<volume>21</volume>
<page-range>295-305</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oh]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[K.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. Biophys. Res. Commun.]]></source>
<year>2013</year>
<volume>430</volume>
<page-range>400-5</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tyagi]]></surname>
<given-names><![CDATA[R.K.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Endocrinol.]]></source>
<year>1998</year>
<volume>12</volume>
<page-range>1684-95</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katagiri]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat. Cell. Biol.]]></source>
<year>2000</year>
<volume>2</volume>
<page-range>435-40</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear hormone receptors and gene expression]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aranda]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Pascual]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Physiol. Rev.]]></source>
<year>2001</year>
<volume>81</volume>
<page-range>1269-304</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The nuclear pore complex and nuclear transport]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wente]]></surname>
<given-names><![CDATA[S.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Rout]]></surname>
<given-names><![CDATA[M.P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cold Spring Harb. Perspect. Biol.]]></source>
<year>2010</year>
<volume>2</volume>
<page-range>562</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Karyopherins and nuclear import]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chook]]></surname>
<given-names><![CDATA[Y.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Blobel]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr. Opin. Struct. Biol.]]></source>
<year>2001</year>
<volume>11</volume>
<page-range>703-15</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRM1-mediated nuclear export: to the pore and beyond]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hutten]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kehlenbach]]></surname>
<given-names><![CDATA[R.H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends Cell Biol.]]></source>
<year>2007</year>
<volume>17</volume>
<page-range>193-201</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Importin alpha: a multipurpose nuclear-transport receptor]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldfarb]]></surname>
<given-names><![CDATA[D.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends Cell Biol.]]></source>
<year>2004</year>
<volume>14</volume>
<page-range>505-14</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[DNA binding domains in diverse nuclear receptors function as nuclear export signals]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Black]]></surname>
<given-names><![CDATA[B.E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr. Biol.]]></source>
<year>2001</year>
<volume>11</volume>
<page-range>1749-58</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The nuclear pore complex]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bagley]]></surname>
<given-names><![CDATA[S.,]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell. Sci.]]></source>
<year>2000</year>
<volume>113</volume>
<page-range>3885-6</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lombardi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell. Biol.]]></source>
<year>2008</year>
<volume>182</volume>
<page-range>327-40</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castoria]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Oncogene]]></source>
<year>2012</year>
<volume>31</volume>
<page-range>4868-77</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Papac-Milicevic]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Circ. Res.]]></source>
<year>2012</year>
<volume>110</volume>
<page-range>e50-63</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grespin]]></surname>
<given-names><![CDATA[M.E.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Biol. Chem.]]></source>
<year>2008</year>
<volume>283</volume>
<page-range>25576-88</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin Is a receptor for nuclear export]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Holaska]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell. Biol.]]></source>
<year>2001</year>
<volume>152</volume>
<page-range>127-40</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A 2.1-A-resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saito]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Matsuura]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Mol. Biol.]]></source>
<year>2013</year>
<volume>425</volume>
<page-range>350-64</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Petosa]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Cell.]]></source>
<year>2004</year>
<volume>16</volume>
</nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Krause]]></surname>
<given-names><![CDATA[K.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Michalak]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cell]]></source>
<year>1997</year>
<volume>88</volume>
<page-range>439-43</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michalak]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Robert Parker]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Opas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cell Calcium.]]></source>
<year>2002</year>
<volume>32</volume>
<page-range>269-78</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michalak]]></surname>
<given-names><![CDATA[M.,]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. J.]]></source>
<year>1992</year>
<volume>285</volume>
<page-range>681-92</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin: one protein, one gene, many functions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michalak]]></surname>
<given-names><![CDATA[M.,]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. J.]]></source>
<year>1999</year>
<volume>344</volume>
<page-range>281-92</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Functional Roles of Calreticulin in Cancer Biology]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[Y.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Weng]]></surname>
<given-names><![CDATA[W.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biomed. Res. Int.]]></source>
<year>2015</year>
<page-range>526524</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Exportin 1 (Crm1p) is an essential nuclear export factor]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stade]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cell]]></source>
<year>1997</year>
<volume>90</volume>
<page-range>1041-50</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Identification of a major polypeptide of the nuclear pore complex]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gerace]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Ottaviano]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Kondor-Koch]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell Biol.]]></source>
<year>1982</year>
<volume>95</volume>
<page-range>826-37</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fornerod]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[EMBO J.]]></source>
<year>1997</year>
<volume>16</volume>
<page-range>807-16</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[mRNA export and cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Siddiqui]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Borden]]></surname>
<given-names><![CDATA[K.L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Wiley Interdiscip. Rev. RNA]]></source>
<year>2012</year>
<volume>3</volume>
<page-range>13-25</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Isolation of sarcoplasmic reticulum proteins]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[MacLennan]]></surname>
<given-names><![CDATA[D.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Yip]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Iles]]></surname>
<given-names><![CDATA[G.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Seeman]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cold Spring Harb. Symp. Quant. Biol.]]></source>
<year>1972</year>
<volume>37</volume>
<page-range>469-77</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fliegel]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Biol. Chem.]]></source>
<year>1989</year>
<volume>264</volume>
<page-range>21522-8</page-range></nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ostwald]]></surname>
<given-names><![CDATA[T.J.]]></given-names>
</name>
<name>
<surname><![CDATA[MacLennan]]></surname>
<given-names><![CDATA[D.H.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Biol. Chem.]]></source>
<year>1974</year>
<volume>249</volume>
<page-range>974-9</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Isolation and Characterization of Cab-63, a Novel Calcium-Binding Protein]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Waisman]]></surname>
<given-names><![CDATA[D.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Salimath]]></surname>
<given-names><![CDATA[B.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Biological Chemistry]]></source>
<year>1985</year>
<volume>260</volume>
<page-range>1652-60</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Koch]]></surname>
<given-names><![CDATA[G.L.]]></given-names>
</name>
</person-group>
<source><![CDATA[EMBO J.]]></source>
<year>1989</year>
<volume>8</volume>
<page-range>3581-6</page-range></nlm-citation>
</ref>
<ref id="B45">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mueller]]></surname>
<given-names><![CDATA[C.F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. Biophys. Res. Commun.]]></source>
<year>2008</year>
<volume>370</volume>
<page-range>669-74</page-range></nlm-citation>
</ref>
<ref id="B46">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Functional specialization of calreticulin domains]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell Biol.]]></source>
<year>2001</year>
<volume>154</volume>
<page-range>961-72</page-range></nlm-citation>
</ref>
<ref id="B47">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin and focal-contact-dependent adhesion]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villagómez]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. Cell Biol.]]></source>
<year>2009</year>
<volume>87</volume>
<page-range>545-56</page-range></nlm-citation>
</ref>
<ref id="B48">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Opas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell Physiol.]]></source>
<year>1991</year>
<volume>149</volume>
<page-range>160-71</page-range></nlm-citation>
</ref>
<ref id="B49">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[DeFranco]]></surname>
<given-names><![CDATA[D.B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Endocrinol.]]></source>
<year>1985</year>
<volume>14</volume>
<page-range>40-51</page-range></nlm-citation>
</ref>
<ref id="B50">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[inhibition of signal-mediated nuclear export by direct binding to CRM1]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kudo]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Leptomycin]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Exp. Cell. Res.]]></source>
<year>1998</year>
<volume>242</volume>
<page-range>540-7</page-range></nlm-citation>
</ref>
<ref id="B51">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cytoplasmic localization of the androgen receptor is independent of calreticulin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[M.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Cell Endocrinol.]]></source>
<year>2009</year>
<volume>302</volume>
<page-range>65-72</page-range></nlm-citation>
</ref>
<ref id="B52">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical translation of nuclear export inhibitors in cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Senapedis]]></surname>
<given-names><![CDATA[W.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Baloglu]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Landesman]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Semin. Cancer Biol.]]></source>
<year>2014</year>
<volume>27</volume>
<page-range>74-86</page-range></nlm-citation>
</ref>
<ref id="B53">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gravina]]></surname>
<given-names><![CDATA[G.L.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Hematol. Oncol.]]></source>
<year>2014</year>
<volume>7</volume>
<page-range>46</page-range></nlm-citation>
</ref>
<ref id="B54">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Freedman]]></surname>
<given-names><![CDATA[D.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Cell Biol.]]></source>
<year>1998</year>
<volume>18</volume>
<page-range>7288-93</page-range></nlm-citation>
</ref>
<ref id="B55">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Overexpression of calreticulin contributes to the development and progression of pancreatic cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sheng]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell Physiol.]]></source>
<year>2014</year>
<volume>229</volume>
<page-range>887-97</page-range></nlm-citation>
</ref>
<ref id="B56">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinicopathological significance of calreticulin in breast invasive ductal carcinoma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lwin]]></surname>
<given-names><![CDATA[Z.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mod. Pathol.]]></source>
<year>2010</year>
<volume>23</volume>
<page-range>1559-66</page-range></nlm-citation>
</ref>
<ref id="B57">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Inhibition of glycogen synthase kinase-3beta promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schutz]]></surname>
<given-names><![CDATA[S.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Cronauer]]></surname>
<given-names><![CDATA[M.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Rinnab]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cell Biochem.]]></source>
<year>2010</year>
<volume>109</volume>
<page-range>1192-200</page-range></nlm-citation>
</ref>
<ref id="B58">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Model system to study classical nuclear export signals]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanwal]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[C.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[AAPS PharmSci.]]></source>
<year>2002</year>
<volume>4</volume>
<page-range>E18</page-range></nlm-citation>
</ref>
<ref id="B59">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin: from Ca2+ binding to control of gene expression]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burns]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends Cell Biol.]]></source>
<year>1994</year>
<volume>4</volume>
<page-range>152-4</page-range></nlm-citation>
</ref>
<ref id="B60">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Calreticulin inhibits vitamin D's action on the PTH gene in vitro and may prevent vitamin D's effect in vivo in hypocalcemic rats]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sela-Brown]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Endocrinol.]]></source>
<year>1998</year>
<volume>12</volume>
<page-range>1193-200</page-range></nlm-citation>
</ref>
<ref id="B61">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Retinoid X. receptor dominates the nuclear import and export of the unliganded vitamin D receptor]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Prufer]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Barsony]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol. Endocrinol.]]></source>
<year>2002</year>
<volume>16</volume>
<page-range>1738-51</page-range></nlm-citation>
</ref>
<ref id="B62">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ligand-dependent nucleo-cytoplasmic shuttling of peroxisome proliferator-activated receptors PPARalpha and PPARgamma.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Umemoto]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Fujiki]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Genes Cells]]></source>
<year>2012</year>
<volume>17</volume>
<page-range>576-96</page-range></nlm-citation>
</ref>
<ref id="B63">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nuclear export signal of androgen receptor (NESAR) regulation of androgen receptor level in human prostate cell lines via ubiquitination and proteasome-dependent degradation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gong]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Endocrinology]]></source>
<year>2012</year>
<volume>153</volume>
<page-range>5716-25</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
