<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-5546</journal-id>
<journal-title><![CDATA[Computación y Sistemas]]></journal-title>
<abbrev-journal-title><![CDATA[Comp. y Sist.]]></abbrev-journal-title>
<issn>1405-5546</issn>
<publisher>
<publisher-name><![CDATA[Instituto Politécnico Nacional, Centro de Investigación en Computación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-55462018000401573</article-id>
<article-id pub-id-type="doi">10.13053/cys-22-4-2834</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Modelado de distribución de temperatura de nanopartículas de Fe3O4 para terapia oncológica]]></article-title>
<article-title xml:lang="en"><![CDATA[Modeling of Temperature Distribution of Fe3O4 Nanoparticles for Oncological Therapy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero Coripuna]]></surname>
<given-names><![CDATA[Rosario Lissiet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cordova Fraga]]></surname>
<given-names><![CDATA[Teodoro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Basurto Islas]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villaseñor Mora]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán Cabrera]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guanajuato División de Ciencias e Ingenierías ]]></institution>
<addr-line><![CDATA[León ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Guanajuato División de Ingenierías ]]></institution>
<addr-line><![CDATA[Irapuato-Salamanca ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>1573</fpage>
<lpage>1579</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-55462018000401573&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-55462018000401573&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-55462018000401573&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Las células humanas con cáncer sufren cambios fisiológicos en el rango de temperaturas de 42 °C a 45 °C, provocando por lo tanto la muerte celular por apoptosis. Los métodos para alcanzar estas temperaturas ya han sido investigados debido a su aplicación biomédica. La hipertermia magnética es una terapia oncológica alternativa, sin embargo, la distribución de la temperatura en el tejido transformado sigue siendo poco clara en absoluto y su determinación en el rango de temperatura óptima de 42 °C a 45 °C exige una respuesta. COMSOL Multiphysics es una excelente alternativa para dar solución a esta exigencia. En este trabajo se presenta una simulación de temperatura a partir de varias cantidades de nano partículas. Los resultados preliminares sugieren que el gradiente de temperatura disminuye drásticamente a medida que disminuye el número de nano partículas, de modo que se busca la temperatura óptima y el número de nano partículas de magnetita para tratar eficientemente el volumen del tejido transformado de interés. Como primera conclusión, lo anterior se consiguió obteniendo el número de partículas a utilizar y una distancia efectiva de separación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Human cells with cancer undergo physiological changes at temperatures of 42 °C to 45 °C thereby causing cell death by apoptosis. The methods for achieving these temperatures have already been investigated because of their biomedical application. Magnetic Hyperthermia is an alternative oncology therapy, nevertheless, the temperature distribution in transformed tissue remains unclear at all and its determination in an optimal temperature segment from 42 oC to 45 oC is demanding an answer. COMSOL multiphysics 5.2 is an excellent alternative for giving the answer to the previous question. In this work was made a temperature simulation from several quantities of the nanoparticle. Preliminary results suggest that the temperature gradient drops dramatically as the number of nanoparticles decrease, so that the optimal temperature and nanoparticles number are sought to address efficiently the volume of transformed fabric of interest. As first conclusion, the above was achieved by obtaining the number of particles to be used and an effective separation distance.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[gradiente]]></kwd>
<kwd lng="es"><![CDATA[temperatura]]></kwd>
<kwd lng="es"><![CDATA[hipertermia]]></kwd>
<kwd lng="es"><![CDATA[COMSOL]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas]]></kwd>
<kwd lng="es"><![CDATA[magnetita]]></kwd>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[temperature gradient]]></kwd>
<kwd lng="en"><![CDATA[hyperthermia]]></kwd>
<kwd lng="en"><![CDATA[COMSOL]]></kwd>
<kwd lng="en"><![CDATA[nanoparticles]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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