<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-5546</journal-id>
<journal-title><![CDATA[Computación y Sistemas]]></journal-title>
<abbrev-journal-title><![CDATA[Comp. y Sist.]]></abbrev-journal-title>
<issn>1405-5546</issn>
<publisher>
<publisher-name><![CDATA[Instituto Politécnico Nacional, Centro de Investigación en Computación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-55462018000401559</article-id>
<article-id pub-id-type="doi">10.13053/cys-22-4-2827</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Tree-based Secondary Structure Interactions Predictor Method for Protein Contact Maps]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintana-Zaez]]></surname>
<given-names><![CDATA[Julio C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Molina-Ruiz]]></surname>
<given-names><![CDATA[Reinaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santiesteban-Toca]]></surname>
<given-names><![CDATA[Cosme E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,University of Ciego de Ávila &#8220;Máximo Gómez Báez&#8221; Faculty of Informatics ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Central University &#8220;Marta Abreu&#8221; Informatics Research Center ]]></institution>
<addr-line><![CDATA[Santa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,University of Ciego de Ávila &#8220;Máximo Gómez Báez&#8221; Bioplantas Research Center ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Central University &#8220;Marta Abreu&#8221; Center of Chemical Reagents ]]></institution>
<addr-line><![CDATA[Santa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>1559</fpage>
<lpage>1571</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-55462018000401559&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-55462018000401559&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-55462018000401559&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Understanding the folding of proteins is one of the most interesting research field for the Bioinformatics. The contact maps constitute an intermediate step in the prediction of the 3D structure of the proteins and allow to represent folding patterns. Currently, the methods used to predict contact maps achieve low precision results, only about 25% of long-range (L/5) contacts are correctly predicted, and their knowledge base is not humanly interpretable. In this paper, we propose an easy implementation multiple classifier for contact maps, which is based on patterns of interaction between secondary structures and employed decision trees as base classifiers. This method is able to naturally reduce the level of imbalance between contact/non-contact classes. In addition, a set of interpretable rules are extracted as a complement to the prediction. The validation of method performance shows that an average of 45% of general contacts are correctly predicted. Moreover, a Z-score comparison of its long-range contacts predictions (L/5) with participant methods in CASP11 competition shows that it is competitive with the state-of-the-art methods.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Contact maps]]></kwd>
<kwd lng="en"><![CDATA[folding patterns]]></kwd>
<kwd lng="en"><![CDATA[decision trees]]></kwd>
<kwd lng="en"><![CDATA[long-range contacts]]></kwd>
</kwd-group>
</article-meta>
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