<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-5546</journal-id>
<journal-title><![CDATA[Computación y Sistemas]]></journal-title>
<abbrev-journal-title><![CDATA[Comp. y Sist.]]></abbrev-journal-title>
<issn>1405-5546</issn>
<publisher>
<publisher-name><![CDATA[Instituto Politécnico Nacional, Centro de Investigación en Computación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-55462017000300537</article-id>
<article-id pub-id-type="doi">10.13053/cys-21-3-2495</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Automatic Classification of Traced Neurons Using Morphological Features]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Cabrera]]></surname>
<given-names><![CDATA[José D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lorenzo-Ginori]]></surname>
<given-names><![CDATA[Juan V.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Central &#8220;Marta Abreu&#8221; de Las Villas Centro de Investigaciones en Informática ]]></institution>
<addr-line><![CDATA[Santa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<volume>21</volume>
<numero>3</numero>
<fpage>537</fpage>
<lpage>544</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-55462017000300537&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-55462017000300537&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-55462017000300537&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The great advances in the field of neuron tracing have made possible a high availability of free-access data in the Internet, which motivates the realization of automatic classifications. The increase of neuronal reconstruction databases makes the manual classification of neurons a time-consuming and tedious task for the analysts. Classification by human experts is also prone to inter- and intra-analyst variability due to the process&#8217; inherent subjectivity. In this context, the need arises to find new descriptors having discriminative properties which allow separating the various neuron classes, and this constitutes currently an open problem. Such descriptors would contribute to improve the results of automatic classification. In this study the attention is focused on the use of new morphological features in supervised classification of traced neurons. Furthermore, we present a comparative analysis of different supervised learning algorithms oriented to the classification of reconstructed neurons. The results were validated using non-parametric statistical tests and they show the usefulness of the proposed solution.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Neuron tracing]]></kwd>
<kwd lng="en"><![CDATA[morphological features]]></kwd>
<kwd lng="en"><![CDATA[feature selection]]></kwd>
<kwd lng="en"><![CDATA[automatic classification]]></kwd>
<kwd lng="en"><![CDATA[non-parametric tests]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguiar]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Szucs]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Versatile morphometric analysis and visualization of the three-dimensional structure of neurons]]></article-title>
<source><![CDATA[Neuroinformatics]]></source>
<year>2013</year>
<volume>11</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>393-403</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Armañanzas]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ascoli]]></surname>
<given-names><![CDATA[G.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Towards the automatic classification of neurons]]></article-title>
<source><![CDATA[Trends in neurosciences]]></source>
<year>2015</year>
<volume>38</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>307-18</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ascoli]]></surname>
<given-names><![CDATA[G. A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sharing Neuron Data: Carrots, Sticks, and Digital Records]]></article-title>
<source><![CDATA[PLoS Biol]]></source>
<year>2015</year>
<volume>13</volume>
<numero>10</numero>
<issue>10</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calvo]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Santafe]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[scmamp: Statistical Comparison of Multiple Algorithms in Multiple Problems]]></article-title>
<source><![CDATA[The R Journal]]></source>
<year>2016</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cerpa]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Bardeen]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Astudillo]]></surname>
<given-names><![CDATA[C.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Verner]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluating different families of prediction methods for estimating software project outcomes]]></article-title>
<source><![CDATA[Journal of Systems and Software]]></source>
<year>2016</year>
<volume>112</volume>
<page-range>48-64</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cunningham]]></surname>
<given-names><![CDATA[S.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Denize]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A tool for model generation and knowledge acquisition]]></article-title>
<source><![CDATA[Selecting Models from Data]]></source>
<year>1994</year>
<page-range>471-8</page-range><publisher-name><![CDATA[Springer]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cuntz]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Forstner]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Borst]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Häusser]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[One rule to grow them all: a general theory of neuronal branching and its practical application]]></article-title>
<source><![CDATA[PLoS Comput Biol]]></source>
<year>2010</year>
<volume>6</volume>
<numero>8</numero>
<issue>8</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández-Delgado]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Cernadas]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Barro]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Amorim]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Do we need hundreds of classifiers to solve real world classification problems?]]></article-title>
<source><![CDATA[The Journal of Machine Learning Research]]></source>
<year>2014</year>
<volume>15</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3133-81</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Foster]]></surname>
<given-names><![CDATA[K.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Koprowski]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Skufca]]></surname>
<given-names><![CDATA[J.D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Machine learning, medical diagnosis, and biomedical engineering research-commentary]]></article-title>
<source><![CDATA[BioMedical Engineering OnLine]]></source>
<year>2014</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Segura]]></surname>
<given-names><![CDATA[L.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Perez-Marquez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A new mathematical function to evaluate neuronal morphology using the Sholl analysis]]></article-title>
<source><![CDATA[Journal of neuroscience methods]]></source>
<year>2014</year>
<volume>226</volume>
<page-range>103-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gensel]]></surname>
<given-names><![CDATA[J.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Schonberg]]></surname>
<given-names><![CDATA[D.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Alexander]]></surname>
<given-names><![CDATA[J.K.]]></given-names>
</name>
<name>
<surname><![CDATA[McTigue]]></surname>
<given-names><![CDATA[D.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Popovich]]></surname>
<given-names><![CDATA[P.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Semi-automated Sholl analysis for quantifying changes in growth and differentiation of neurons and glia]]></article-title>
<source><![CDATA[Journal of Neuroscience Methods]]></source>
<year>2010</year>
<volume>190</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>71-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gillette]]></surname>
<given-names><![CDATA[T.A]]></given-names>
</name>
</person-group>
<source><![CDATA[Comparative Topological Analysis of Neuronal Arbors via Sequence Representation and Alignment]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Glaser]]></surname>
<given-names><![CDATA[J.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Kording]]></surname>
<given-names><![CDATA[K.P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Development and Analysis of Integrated Neuroscience Data]]></article-title>
<source><![CDATA[Frontiers in Computational Neuroscience]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[McGarry]]></surname>
<given-names><![CDATA[L.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Robles]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Bielza]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Larrañaga]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Yuste]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison between supervised and unsupervised classifications of neuronal cell types: A case study]]></article-title>
<source><![CDATA[Developmental Neurobiology]]></source>
<year>2011</year>
<volume>71</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>71-82</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Halavi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Polavaram]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Donohue]]></surname>
<given-names><![CDATA[D.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Hamilton]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Hoyt]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[K. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Ascoli]]></surname>
<given-names><![CDATA[G. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[NeuroMorpho.Org implementation of digital neuroscience: dense coverage and integration with the NIF]]></article-title>
<source><![CDATA[Neuroinformatics]]></source>
<year>2008</year>
<volume>6</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>241-52</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[M.A]]></given-names>
</name>
</person-group>
<source><![CDATA[Correlation-based feature selection for machine learning]]></source>
<year>1999</year>
<publisher-name><![CDATA[The University of Waikato]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ledderose]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sención]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Salgado]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Arias-Carrión]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Treviño]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A software tool for the analysis of neuronal morphology data]]></article-title>
<source><![CDATA[International Archives of Medicine]]></source>
<year>2014</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leguey]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Bielza]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Larrañaga]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Kastanauskaite]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rojo]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Benavides-Piccione]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[De Felipe]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dendritic branching angles of pyramidal cells across layers of the juvenile rat somatosensory cortex]]></article-title>
<source><![CDATA[Journal of Comparative Neurology]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Carin]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Coifman]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Shain]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Roysam]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantitative arbor analytics: unsupervised harmonic co-clustering of populations of brain cell arbors based on L-measure]]></article-title>
<source><![CDATA[Neuroinformatics]]></source>
<year>2014</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>47-63</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McGarry]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Packer]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fino]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Nikolenko]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Sippy]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Yuste]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantitative classification of somatostatin-positive neocortical interneurons identifies three interneuron subtypes]]></article-title>
<source><![CDATA[Frontiers in neural circuits]]></source>
<year>2010</year>
<volume>4</volume>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parekh]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ascoli]]></surname>
<given-names><![CDATA[G. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantitative Investigations of Axonal and Dendritic Arbors Development, Structure, Function, and Pathology]]></article-title>
<source><![CDATA[The Neuroscientist]]></source>
<year>2015</year>
<volume>21</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>241-54</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scorcioni]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Polavaram]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Ascoli]]></surname>
<given-names><![CDATA[G.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[L-Measure: a Web-accessible tool for the analysis, comparison, and search of digital reconstructions of neuronal morphologies]]></article-title>
<source><![CDATA[Nature protocols]]></source>
<year>2008</year>
<volume>3</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>866-76</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vasques]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Vanel]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Villette]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Cif]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Morphological Neuron Classification Using Machine Learning]]></article-title>
<source><![CDATA[Frontiers in Neuroanatomy]]></source>
<year>2016</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
