<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-2768</journal-id>
<journal-title><![CDATA[Polibotánica]]></journal-title>
<abbrev-journal-title><![CDATA[Polibotánica]]></abbrev-journal-title>
<issn>1405-2768</issn>
<publisher>
<publisher-name><![CDATA[Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-27682017000100165</article-id>
<article-id pub-id-type="doi">10.18387/polibotanica.43.7</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Cytotoxic studies and in vitro effects of trans-3,4,4',5-tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth]]></article-title>
<article-title xml:lang="es"><![CDATA[Estudios Citotóxicos y efectos in vitro de trans-3,4,4',5-tetrametoxiestilbeno, compuesto bioactivo aislado de Lonchocarpus punctatus Kunth]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Borges-Argáez]]></surname>
<given-names><![CDATA[Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cáceres-Farfán]]></surname>
<given-names><![CDATA[Mirbella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pedro]]></surname>
<given-names><![CDATA[Nuria De]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cautain]]></surname>
<given-names><![CDATA[Bastien]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Del Palacio]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vicente]]></surname>
<given-names><![CDATA[Francisca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Genilloud]]></surname>
<given-names><![CDATA[Olga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Melguizo]]></surname>
<given-names><![CDATA[Angeles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[El Aouad]]></surname>
<given-names><![CDATA[Noureddine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sansores-Peraza]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Investigación Científica de Yucatán  ]]></institution>
<addr-line><![CDATA[Mérida Yucatán]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación MEDINA  ]]></institution>
<addr-line><![CDATA[ Granada]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Yucatán  ]]></institution>
<addr-line><![CDATA[Mérida Yucatán]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<numero>43</numero>
<fpage>165</fpage>
<lpage>175</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-27682017000100165&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-27682017000100165&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-27682017000100165&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The bioassay-guided fractionation of Lonchocarpus punctatus inflorescence extracts led to the purification of the trans (1) and cis (2) isomers of 3,5-dimethoxystilbene, trans-3,4,4&#8217;,5-tetramethoxystilbene (3), 4,4&#8217;,6&#8217;-trimethoxychalcone (4) and 5- hydroxy-7,4&#8217;-dimethoxyflavone (5) as their main constituents. the structures of the compounds were established by comparing their nuclear magnetic resonance and mass spectrometry data with that from the literature. among these metabolites, trans-3,4,4&#8217;,5-tetramethoxystilbene (3) exhibited potent cytotoxic activity against luminal a (CC50= 2.2 &#956;M), HER2 (CC50= 1.1 &#956;M) and basal triple negative (CC50= 1.8 &#956;M) breast cancer cell lines, but no cytotoxic effects were observed against immortalized hepatocyte cell lines (CC50&gt; 50 &#956;M), and medium (CYP3A4, CYP2C9) and low (CYP2D6) inhibitory properties were observed for P450 isoforms.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El fraccionamiento biodirigido de extractos obtenidos de las inflorescencias de Lonchocarpus punctatus Kunth permitieron la purificación de los isómeros trans (1) y cis (2) de 3,5 dimetoxiestilbeno, trans-3,4,4&#8217;,5- tetrametoxiestilbeno (3) 4,4&#8217;,6&#8217;-trimetoxichalcona (4) y 5-hidroxi-7,4&#8217;-dimetoxiflavona (5) como sus principales constituyentes. Las estructuras de los compuestos fueron establecidas por comparación de sus datos de resonancia magnética nuclear y espectrometría de masas con los reportados en la literatura. De todos los metabolitos aislados, trans-3,4.4&#8217;,5-tetrametoxiestilbeno (3) exhibió potente actividad citotóxica contra las líneas celulares de cáncer luminal a (CC50= 2.2 &#956;M), HEr2 (CC50 = 1.1 &#956;M) y triple negativo basal (CC50= 1.8 &#956;M) pero ningún efecto citotóxico fue observado contra la línea celular inmortalizada de hepatocitos (CC50 &gt; 50 &#956;M), así como propiedades inhibitorias moderadas (CYP3A4, CYP2C9) y bajas (CYP2D6) en las isoformas del citocromo P450.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[inflorescence]]></kwd>
<kwd lng="en"><![CDATA[Lonchocarpus punctatus]]></kwd>
<kwd lng="en"><![CDATA[trans-3,4,4&#8217;,5-tetramethoxystilbene]]></kwd>
<kwd lng="en"><![CDATA[breast cancer cell lines]]></kwd>
<kwd lng="en"><![CDATA[cytochrome P450]]></kwd>
<kwd lng="es"><![CDATA[inflorescencia]]></kwd>
<kwd lng="es"><![CDATA[Lonchocarpus punctatus]]></kwd>
<kwd lng="es"><![CDATA[trans-3,4,4&#8217;,5-tetrametoxistilbene]]></kwd>
<kwd lng="es"><![CDATA[líneas celulares cancerígenas de mama]]></kwd>
<kwd lng="es"><![CDATA[citocromo P450]]></kwd>
</kwd-group>
</article-meta>
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