<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0484-7903</journal-id>
<journal-title><![CDATA[Revista mexicana de anestesiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. anestesiol.]]></abbrev-journal-title>
<issn>0484-7903</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Anestesiología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0484-79032021000100043</article-id>
<article-id pub-id-type="doi">10.35366/97776</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Consideraciones analgésicas sobre el manejo del dolor agudo en el adulto mayor]]></article-title>
<article-title xml:lang="en"><![CDATA[Considerations for acute pain analgesic management in the elderly]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Covarrubias-Gómez]]></surname>
<given-names><![CDATA[Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Pérez]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Templos-Esteban]]></surname>
<given-names><![CDATA[Luz A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Collada Estrada]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición «Salvador Zubirán» Departamento de Medicina del Dolor y Paliativa ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Rehabilitación División de Anestesiología y Clínica del Dolor ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital General «Dr. Manuel Gea González» División de Cuidados Paliativos y Clínica del Dolor ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro Estatal de Cancerología de Chihuahua Departamento de Cuidados Paliativos ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Chihuahua</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>44</volume>
<numero>1</numero>
<fpage>43</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0484-79032021000100043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0484-79032021000100043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0484-79032021000100043&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En las últimas décadas se ha registrado un aumento dramático en la esperanza de vida. La principal morbilidad de este grupo poblacional son las enfermedades crónico-degenerativas, las cuales frecuentemente se acompañan de dolor. No es de extrañarse que cada vez más pacientes ancianos sean intervenidos quirúrgicamente; hasta 62% de ellos reportan dolor agudo postoperatorio (DAPO) severo. El envejecimiento se asocia a una respuesta reducida al estímulo doloroso, fenómeno conocido como presbialgesia, lo cual se traduce en menores requerimientos analgésicos. Cuando el paciente anciano cuenta con demencia u otras alteraciones de la cognición se deberán utilizar escalas conductuales. Existen diversas condiciones fisiológicas en el anciano que lo hacen propenso a acumulación de fármacos y retraso en su eliminación. Además, existe un riesgo aumentado de interacciones farmacológicas por polifarmacia, hechos que se deberán tener en cuenta al abordar clínicamente el dolor en el paciente geriátrico. Los antiinflamatorios no esteroideos (AINE) son considerados de riesgo en ancianos frágiles por aumentar el riesgo de sangrado, sin mencionar el potencial daño en pacientes nefrópatas o con trastornos de la coagulación. El paracetamol es un analgésico noble a nivel gástrico, renal y cardiovascular. Es considerado primera línea en osteoartrosis degenerativa. Se sugiere no sobrepasar dos gramos al día en ancianos frágiles. Al utilizar analgésicos opioides se sugiere iniciar con la mínima dosis analgésica y escalar lentamente en caso de que el alivio del dolor lo requiera, evitando así efectos adversos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Over the last few decades the elderly population is growing by the second. Most of their illnesses are of the chronic degenerative type, many of which are very painful. Also, more and more elderly patients are requiring surgery for a number of reasons; 62% of these patients will experience severe postoperatory pain. Aging is associated with presbialgesia, which is a reduced response to a noxious stimule. When these patients have dementia or other cognitive impairment conductual scales such must be utilized. There elderly might be more sensitive to analgesic drugs due to various and unique physiological aspects. NSAIDs are considered high risk drugs in fragile elderly patients. Acetaminophen is a safe analgesic drug without many gastrointestinal, renal or cardiovascular secondary effects. Nevertheless, a fragile elderly patient should not receive more than 2 grams daily. When giving opioids, one should start with the minimum dose and titrate slowly when needed in order to avoid adverse effects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dolor]]></kwd>
<kwd lng="es"><![CDATA[agudo]]></kwd>
<kwd lng="es"><![CDATA[dolor postoperatorio]]></kwd>
<kwd lng="es"><![CDATA[adulto mayor]]></kwd>
<kwd lng="es"><![CDATA[geriatría]]></kwd>
<kwd lng="en"><![CDATA[Pain]]></kwd>
<kwd lng="en"><![CDATA[acute pain]]></kwd>
<kwd lng="en"><![CDATA[postoperative pain]]></kwd>
<kwd lng="en"><![CDATA[elderly]]></kwd>
<kwd lng="en"><![CDATA[geriatrics]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="">
<collab>Instituto Nacional de Estadística y Geografía (INEGI)</collab>
<source><![CDATA[Del portal en Internet sección Estadística y tema Población]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Borges-Yáñez]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez-Dantés]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uso de los servicios de salud por la población de 60 años y más en México]]></article-title>
<source><![CDATA[Salud Publica Mex]]></source>
<year>1998</year>
<volume>40</volume>
<page-range>13-23</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Olaiz-Fernández]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rivera-Dommarco]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Shamah-Levy]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Villalpando-Hernández]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández-Ávila]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Encuesta Nacional de Salud y Nutrición 2006]]></source>
<year>2006</year>
<publisher-loc><![CDATA[Cuernavaca, México ]]></publisher-loc>
<publisher-name><![CDATA[Instituto Nacional de Salud Pública]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Valdespino]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Olaiz]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[López-Barajas]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Palma]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Velázquez]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Encuesta Nacional de Salud 2000. Tomo I. Vivienda, población y utilización de servicios de salud]]></source>
<year>2003</year>
<publisher-loc><![CDATA[Cuernavaca, Morelos, México ]]></publisher-loc>
<publisher-name><![CDATA[Instituto Nacional de Salud Pública]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guevara-López]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Covarrubias-Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández-Ortiz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Desarrollo de los parámetros de práctica para el manejo del dolor agudo]]></article-title>
<source><![CDATA[Rev Mex Anest]]></source>
<year>2004</year>
<volume>27</volume>
<page-range>200-4</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Hernández]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experiencia mexicana de la Unidad de Dolor Agudo: Instituto Mexicano del Seguro Social (IMSS)]]></article-title>
<source><![CDATA[Rev Mex Anest]]></source>
<year>2013</year>
<volume>36</volume>
<page-range>S176-8</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sauaia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Min]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Leber]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Erbacher]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Abrams]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Fink]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Postoperative pain management in elderly patients: correlation between adherence to treatment guidelines and patient satisfaction]]></article-title>
<source><![CDATA[J Am Geriatr Soc]]></source>
<year>2005</year>
<volume>53</volume>
<page-range>274-82</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leininger]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Managing pain in the older adult patient]]></article-title>
<source><![CDATA[Topics Emerg Med]]></source>
<year>2002</year>
<volume>24</volume>
<page-range>10-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="book">
<collab>Instituto Mexicano del Seguro Social</collab>
<source><![CDATA[Guía de Práctica Clínica: Manejo de síndromes geriátricos asociados a complicaciones postoperatorias]]></source>
<year></year>
<publisher-name><![CDATA[Catálogo maestro de GPC: IMSS-612-13]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guevara-López]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Covarrubias-Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Delille-Fuentes]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández-Ortiz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Carrillo-Esper]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Moyao-García]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Parámetros de práctica para el manejo del dolor agudo perioperatorio]]></article-title>
<source><![CDATA[Cir Cir]]></source>
<year>2005</year>
<volume>73</volume>
<page-range>223-32</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruckenthal]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of pain in the elderly adult]]></article-title>
<source><![CDATA[Clin Geriatr Med]]></source>
<year>2008</year>
<volume>24</volume>
<page-range>213-36</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Catananti]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gambassi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pain assessment in the elderly]]></article-title>
<source><![CDATA[Surg Oncol]]></source>
<year>2010</year>
<volume>19</volume>
<page-range>140-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McCleane]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacological pain management in the elderly patient]]></article-title>
<source><![CDATA[Clin Interv Aging]]></source>
<year>2007</year>
<volume>2</volume>
<page-range>637-43</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Faria]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Caramelli]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Alvarenga]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Galhardoni]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Siqueira]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The assessment and management of pain in the demented and non-demented elderly patient]]></article-title>
<source><![CDATA[Arq Neuropsiquiatr]]></source>
<year>2011</year>
<volume>69</volume>
<page-range>387-94</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kremer]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Atkinson]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Ignelzi]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Measurement of pain: patient preference does not confound pain measurement]]></article-title>
<source><![CDATA[Pain]]></source>
<year>1981</year>
<volume>10</volume>
<page-range>241-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wynne]]></surname>
<given-names><![CDATA[CF]]></given-names>
</name>
<name>
<surname><![CDATA[Ling]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Remsburg]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of pain assessment instruments in cognitively intact and cognitively impaired nursing home residents]]></article-title>
<source><![CDATA[Geriatr Nurs]]></source>
<year>2000</year>
<volume>21</volume>
<page-range>20-3</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herr]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Spratt]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Mobily]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
<name>
<surname><![CDATA[Richardson]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pain intensity assessment in older adults: use of experimental pain to compare psychometric properties and usability of selected pain scales with younger adults]]></article-title>
<source><![CDATA[Clin J Pain]]></source>
<year>2004</year>
<volume>20</volume>
<page-range>207-19</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stuppy]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The faces pain scale: reliability and validity with mature adults]]></article-title>
<source><![CDATA[Appl Nurs Res]]></source>
<year>1998</year>
<volume>11</volume>
<page-range>84-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Herr]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pain intensity assessment: a comparison of selected pain intensity scales for use in cognitively intact and cognitively impaired African American older adults]]></article-title>
<source><![CDATA[Pain Manag Nurs]]></source>
<year>2003</year>
<volume>4</volume>
<page-range>87-95</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hadjistavropoulos]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Herr]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Prkachin]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Craig]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lukas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pain assessment in elderly adults with dementia]]></article-title>
<source><![CDATA[Lancet Neurol]]></source>
<year>2014</year>
<volume>13</volume>
<page-range>1216-27</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fremptom]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experience assessment and management of pain in people with dementia]]></article-title>
<source><![CDATA[Age Ageing]]></source>
<year>2003</year>
<volume>32</volume>
<page-range>248-51</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bressler]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bahl]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Principles of drug therapy for the elderly patient]]></article-title>
<source><![CDATA[Mayo Clin Proc]]></source>
<year>2003</year>
<volume>78</volume>
<page-range>1564-77</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Power]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recent advances in postoperative pain therapy]]></article-title>
<source><![CDATA[Br J Anaesth]]></source>
<year>2005</year>
<volume>95</volume>
<page-range>43-51</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poisson-Salomon]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[De Chambine]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lory]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Patient-related factors and professional practices associated with postoperative pain]]></article-title>
<source><![CDATA[Rev Epidemiol Sante Publique]]></source>
<year>2005</year>
<volume>53</volume>
<page-range>1S47-56</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McLachlan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bath]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Naganathan]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Hilmer]]></surname>
<given-names><![CDATA[SN]]></given-names>
</name>
<name>
<surname><![CDATA[Le Couteur]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment]]></article-title>
<source><![CDATA[Br J Clin Pharmacol]]></source>
<year>2011</year>
<volume>71</volume>
<page-range>351-64</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Covarrubias-Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[González-García]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Betancourt-Sandoval]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza-Reyes]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El dolor agudo perioperatorio y el paracetamol: una visión basada en la evidencia]]></article-title>
<source><![CDATA[Rev Mex Anest]]></source>
<year>2013</year>
<volume>36</volume>
<page-range>47-55</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Covarrubias-Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Manejo del dolor en el paciente anciano]]></article-title>
<source><![CDATA[Rev Mex Anestesiol]]></source>
<year>2006</year>
<volume>29</volume>
<page-range>S207-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahé]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Bertrand]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Drouet]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Simoneau]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Mazoyer]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bal dit Sollier]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Paracetamol: a hemorrhagic risk factor in patients on warfarin]]></article-title>
<source><![CDATA[Br J Clin Pharmacol]]></source>
<year>2005</year>
<volume>59</volume>
<page-range>371-4</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dharmage]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Allen]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Does regular paracetamol ingestion increase the risk of developing asthma?]]></article-title>
<source><![CDATA[Clin Exp Allergy]]></source>
<year>2011</year>
<volume>41</volume>
<page-range>459-60</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jessurun]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[van Marum]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hermens]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[van Puijenbroek]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Advanced age and female sex as risk factors for high anion gap metabolic acidosis after a drug interaction between paracetamol and flucloxacillin: a case series]]></article-title>
<source><![CDATA[J Am Geriatr Soc]]></source>
<year>2016</year>
<volume>64</volume>
<page-range>e90-3</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kraj&#269;ová]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Matou&#353;ek]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Du&#353;ka]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanism of paracetamol-induced hypotension in critically ill patients: a prospective observational cross-over study]]></article-title>
<source><![CDATA[Aust Crit Care]]></source>
<year>2013</year>
<volume>26</volume>
<page-range>136-41</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gumbrevi&#269;ius]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Sveikata]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sveikatien&#279;]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Stankevi&#269;ius]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity]]></article-title>
<source><![CDATA[Medicina (Kaunas)]]></source>
<year>2012</year>
<volume>48</volume>
<page-range>379-81</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aubrun]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Postoperative morphine administration in the elderly patient]]></article-title>
<collab>French Society of Anesthesia and Resuscitation</collab>
<source><![CDATA[Ann Fr Anesth Reanim]]></source>
<year>2009</year>
<volume>28</volume>
<page-range>e39-41</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fine]]></surname>
<given-names><![CDATA[PG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacological management of persistent pain in older patients]]></article-title>
<source><![CDATA[Clin J Pain]]></source>
<year>2004</year>
<volume>20</volume>
<page-range>220-6</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gagliese]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Jackson]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ritvo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Wowk]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Katz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Age is not an impediment to effective use of patient-controlled analgesia by surgical patients]]></article-title>
<source><![CDATA[Anesthesiology]]></source>
<year>2000</year>
<volume>93</volume>
<page-range>601-10</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
