<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412025000900353</article-id>
<article-id pub-id-type="doi">10.24245/gom.v93i9.319</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Predicción clínica del daño renal en la paciente embarazada y con lupus: un índice para la acción temprana]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical prediction of kidney damage in lupus pregnancy: an index for early intervention.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno Uribe]]></surname>
<given-names><![CDATA[María Nallely]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Velázquez]]></surname>
<given-names><![CDATA[Mary Flor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosales Ortíz]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda Rodríguez]]></surname>
<given-names><![CDATA[Amado]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Star Médica  ]]></institution>
<addr-line><![CDATA[Tlalnepantla Estado de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Médica Sur  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>93</volume>
<numero>9</numero>
<fpage>353</fpage>
<lpage>360</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412025000900353&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412025000900353&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412025000900353&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: Identificar factores clínicos predictores de disfunción renal durante el embarazo en pacientes con lupus eritematoso sistémico y desarrollar un índice predictivo.  MATERIALES Y MÉTODOS: Estudio observacional, analítico y retrospectivo efectuado en pacientes con lupus eritematoso sistémico, embarazadas, sin daño renal al ingreso, atendidas en el Hospital de Ginecoobstetricia 3 del Centro Médico Nacional La Raza. Se hizo un análisis estadístico univariado, bivariado y multivariado mediante regresión logística.  RESULTADOS: Se estudiaron 118 pacientes con lupus, embarazadas, de las que 82 (69.5%) resultaron con disfunción renal. Factores asociados: menor de edad (ORa 0.931, p = 0.047), ausencia de inmunosupresores (ORa 11.582, p = 0.040) y mayor actividad lúpica medida por SLEDAI en el primer trimestre. Se construyó un índice clínico predictivo con sensibilidad del 89%.  CONCLUSIONES: El estudio propone un índice clínico de predicción de disfunción renal en pacientes con lupus eritematoso sistémico, embarazadas, basado en la edad, el tratamiento con inmunosupresores, anticuerpos anti-ADN y actividad lúpica. Su aplicación podrá mejorar el seguimiento perinatal y apoyar decisiones clínicas en poblaciones vulnerables, una vez que esté validado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE: To identify clinical predictors of renal dysfunction during pregnancy in patients with systemic lupus erythematosus (SLE) and to develop a predictive index.  METHODS AND MATERIALS: This observational, analytical, retrospective study was conducted on pregnant patients with systemic lupus erythematosus and no renal damage at admission who were treated at Gynecology and Obstetrics Hospital de Ginecoobstetricia 3 Centro Médico Nacional La Raza. Univariate, bivariate, and multivariate statistical analyses were performed using logistic regression.  RESULTS: A total of 118 pregnant patients with lupus were studied, of whom 82 (69.5%) had renal dysfunction. The associated factors were younger age (ORa = 0.931, p = 0.047), absence of immunosuppressants (ORa = 11.582, p = 0.040), and higher lupus activity, as measured by SLEDAI, in the first trimester. A predictive clinical index with 89% sensitivity was constructed.  CONCLUSIONS: This study proposes a clinical index to predict renal dysfunction in pregnant patients with systemic lupus erythematosus. The index is based on age, treatment with immunosuppressants, anti-DNA antibodies, and lupus activity. Once validated, its application may improve perinatal follow-up and support clinical decisions in vulnerable populations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Lupus eritematoso sistémico]]></kwd>
<kwd lng="es"><![CDATA[embarazo]]></kwd>
<kwd lng="es"><![CDATA[disfunción renal]]></kwd>
<kwd lng="es"><![CDATA[preeclampsia]]></kwd>
<kwd lng="es"><![CDATA[nefritis lúpica]]></kwd>
<kwd lng="en"><![CDATA[Systemic lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Renal dysfunction]]></kwd>
<kwd lng="en"><![CDATA[Preeclampsia]]></kwd>
<kwd lng="en"><![CDATA[Lupus nephritis]]></kwd>
</kwd-group>
</article-meta>
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