<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412025000200031</article-id>
<article-id pub-id-type="doi">10.24245/gom.v93i2.9851</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Comparación de dos esquemas de PGE1 para la inducción del trabajo de parto]]></article-title>
<article-title xml:lang="en"><![CDATA[Comparison of two PGE1 schedules for induction of labor.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Méndez]]></surname>
<given-names><![CDATA[Arlenne]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[Osvaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Santo Tomás  ]]></institution>
<addr-line><![CDATA[Panamá ]]></addr-line>
<country>Panamá</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>93</volume>
<numero>2</numero>
<fpage>31</fpage>
<lpage>39</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412025000200031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412025000200031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412025000200031&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: Comparar un esquema de 3 dosis con otro de máximo 6 dosis de prostaglandina E1 (PGE1) para determinar cuál es más efectivo para alcanzar un puntaje de Bishop favorable, sin incrementar la tasa de cesáreas o los desenlaces perinatales adversos.  MATERIALES Y MÉTODOS: Estudio con asignación al azar, controlado y prospectivo efectuado entre los meses de abril a mayo 2018 en la Maternidad del Hospital Santo Tomás, Panamá. El análisis estadístico se hizo con prueba de &#967;2 para variables cualitativas y con U Mann-Whitney para variables cuantitativas con una p &lt; 0.05.  RESULTADOS:  Se estudiaron 314 pacientes (grupo A: 3 dosis [n = 161] y grupo B: 6 dosis [n = 153]). Las características basales de la población fueron similares en ambos grupos con respecto a las variables reportadas. El análisis del objetivo primario no demostró una diferencia significativa en cuanto a las dosis de PGE1 requeridas para alcanzar un índice de Bishop favorable [3 dosis: 1-2 dosis (0.79) en comparación con 6 dosis: 1-2 dosis (1.10); p = 0.79]. Tampoco surgieron diferencias en relación con las cesáreas [3 dosis: 26.1% comparadas con 6 dosis: 23.5%; RR: 1.11(0.75-1.63); p = 0.79] o la duración del trabajo de parto [3 dosis: 7.7 h (4.7) comparadas con 6 dosis: 7.1 h (4.5); p = 0.19].  CONCLUSIÓN:  El esquema de 25 &#956;g de misoprostol cada 6 horas hasta un máximo de 5 dosis demostró ser seguro para lograr el parto. A pesar de que el esquema de 5 dosis se asoció con una baja incidencia de complicaciones maternas, perinatales y puerperales, los partos exitosos fueron pocos, por lo que 4 dosis pareciera ser una mejor elección en cuanto a la cantidad total recomendada de dosis de PGE1 antes de considerar otras opciones de maduración cervical.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE: To compare a 3-dose regimen with a maximum 6-dose regimen of prostaglandin E1 (PGE1) to determine which is more effective in achieving a favorable Bishop score without increasing the rate of cesarean section or adverse perinatal outcomes.  MATERIALS AND METHODS:  A randomized, controlled, prospective study conducted between April and May 2018 at the Maternity Hospital of Santo Tomás, Panama. Statistical analysis was performed using the a2 chi-square test for qualitative variables and the Mann-Whitney U test for quantitative variables with a p &lt; 0.05.  RESULTS: 314 patients were studied (group A: 3 doses [n = 161] and group B: [6 doses n = 153]). The baseline characteristics of the population were similar in both groups with respect to the reported variables. Analysis of the primary endpoint showed no significant difference in the doses of PGE1 required to achieve a favorable Bishop score [3 doses: 1-2 doses (0.79) versus 6 doses: 1-2 doses (1.10); p = 0.79]. There were also no differences in the number of cesarean sections [3 doses: 26.1% compared to 6 doses: 23.5%; RR: 1.11(0.75-1.63); p = 0.79] or in the duration of labor [3 doses: 7.7 h (4.7) compared to 6 doses: 7.1 h (4.5); p = 0.19].  CONCLUSIONS: The regimen of 25 mg misoprostol every 6 hours up to a maximum of 5 doses was shown to be safe for achieving labor. Although the 5-dose regimen was associated with a low incidence of maternal, perinatal and puerperal complications, there were few successful deliveries, so 4 doses appears to be a better choice in terms of the recommended total number of PGE1 doses before considering other options for cervical ripening.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Inducción del trabajo de parto]]></kwd>
<kwd lng="es"><![CDATA[índice de Bishop]]></kwd>
<kwd lng="es"><![CDATA[misoprostol, prostaglandina E1]]></kwd>
<kwd lng="en"><![CDATA[Induction of labor]]></kwd>
<kwd lng="en"><![CDATA[Bishop index, Misoprostol, Prostaglandin E1]]></kwd>
</kwd-group>
</article-meta>
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