<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412023000500324</article-id>
<article-id pub-id-type="doi">10.24245/gom.v91i5.8393</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Indicación profiláctica de aspirina para prevención de preeclampsia y sus complicaciones en embarazos de alto y moderado riesgo]]></article-title>
<article-title xml:lang="en"><![CDATA[Prophylactic use of aspirin for the prevention of preeclampsia and its complications in high and moderate risk pregnancies.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Félix]]></surname>
<given-names><![CDATA[Lauro Marcoantonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruzado-Ulloa]]></surname>
<given-names><![CDATA[Flavia Avelina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiñones-Colchado]]></surname>
<given-names><![CDATA[Elva Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuya-Candela]]></surname>
<given-names><![CDATA[Edita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Domínguez]]></surname>
<given-names><![CDATA[Sarita Abigail]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda-Prada]]></surname>
<given-names><![CDATA[Anni Stefanny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Mayor de San Marcos Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ Lima]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Mayor de San Marcos  ]]></institution>
<addr-line><![CDATA[ Lima]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Mayor de San Marcos  ]]></institution>
<addr-line><![CDATA[ Lima]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Nacional Mayor de San Marcos  ]]></institution>
<addr-line><![CDATA[ Lima]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>91</volume>
<numero>5</numero>
<fpage>324</fpage>
<lpage>343</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412023000500324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412023000500324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412023000500324&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: Sintetizar la evidencia disponible de los últimos 10 años respecto de la indicación de la aspirina para prevenir la preeclampsia y sus complicaciones en embarazos de alto y moderado riesgo.  METODOLOGÍA: Revisión de cinco bases de datos [Pubmed/Medline, ProQuest, Lilacs, HINARI y Cochrane Central Register of Controlled Trials (CENTRAL)]. Se incluyeron ensayos clínicos aleatorizados, controlados, escritos en español o inglés publicados entre enero de 2010 y enero de 2020. Se emplearon los términos de vocabulario controlado DeCS y MeSH en las distintas interfases. En el caso de ProQuest se introdujeron, además, términos de vocabulario libre. Los detalles de la estrategia de búsqueda se visualizan en anexos.  RESULTADOS: Se identificaron 410 estudios, de los que se seleccionaron 8 que reunieron los criterios de elegibilidad. En dos estudios se encontró un efecto reductor de la aspirina en la incidencia de preeclampsia en comparación con placebo; otros dos estudios encontraron el mismo efecto en la incidencia de preeclampsia con parto pretérmino. No se encontraron estudios con bajo riesgo de sesgo que hubieran reportado un efecto significativo de la aspirina en las complicaciones de preeclampsia, ni en preeclampsia con y sin criterios de severidad.  CONCLUSIONES: La evidencia señala que la aspirina en bajas dosis, indicada antes de las 16 semanas de embarazo, reduce la incidencia de preeclampsia debido a su efecto reductor en el parto pretérmino. A pesar de lo encontrado, la información sigue siendo limitada; de ahí la necesidad de contar con una mayor cantidad de estudios con bajo riesgo de sesgo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE: To synthesize the available evidence of the last 10 years regarding the use of aspirin for the prevention of preeclampsia and its complications in high and moderate risk pregnancies. Methodology: Five electronic databases [Pubmed/Medline, ProQuest, Lilacs, HINARI, and Cochrane Central Register of Controlled Trials (CENTRAL)] were reviewed. Randomized controlled clinical trials in Spanish and English published between 01/01/2010 and 01/01/2020 were considered. The DeCS and MeSH controlled vocabulary terms were used in the different interfaces. In the case of ProQuest, free vocabulary terms were also introduced. The details of the search strategy are displayed in annexes.  RESULTS:  410 studies were identified, of which 8 studies that met the eligibility criteria were selected. 2 studies found a reducing effect of aspirin on the incidence of preeclampsia compared to placebo and another 2 studies found the same effect on the incidence of preeclampsia with preterm delivery. No studies with low risk of bias were found that have reported a significant effect of aspirin on the complications of preeclampsia, nor on preeclampsia with and without criteria of severity.  CONCLUSIONS: there is evidence indicating that low-dose aspirin before 16 weeks of gestation reduces the incidence of preeclampsia, this is due to the reducing impact it has on the incidence of preeclampsia with preterm delivery. Despite the results found, the information is still limited, and it is necessary to have a greater number of studies with low risk of bias.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Preeclampsia]]></kwd>
<kwd lng="es"><![CDATA[aspirina]]></kwd>
<kwd lng="es"><![CDATA[prevención y control]]></kwd>
<kwd lng="es"><![CDATA[embarazo de alto riesgo]]></kwd>
<kwd lng="es"><![CDATA[complicaciones del embarazo]]></kwd>
<kwd lng="en"><![CDATA[Pre-Eclampsia]]></kwd>
<kwd lng="en"><![CDATA[Aspirin]]></kwd>
<kwd lng="en"><![CDATA[prevention and control]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy, High-Risk]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy Complications]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<source><![CDATA[WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience]]></source>
<year>2016</year>
<publisher-name><![CDATA[WHO Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Correa]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Palmeiro]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Soto]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ugarte]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Illanes]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Etiopathogenesis, prediction, and prevention of preeclampsia]]></article-title>
<source><![CDATA[Hypertens Pregnancy]]></source>
<year>2016</year>
<volume>35</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>280-94</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Say]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chou]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gemmill]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Tunçalp]]></surname>
<given-names><![CDATA[Ö]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Global causes of maternal death: a WHO systematic analysis]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2014</year>
<volume>2</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>E323-33</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bryce-Moncloa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Alegría-Valdivia]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Valenzuela-Rodríguez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Larrauri-Vigna]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Urquiaga-Calderón]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[San Martín-San Martín]]></surname>
<given-names><![CDATA[MG.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hipertensión en el embarazo]]></article-title>
<source><![CDATA[rev. peru. ginecol. obstet]]></source>
<year>2018</year>
<volume>64</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>191-6</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Turbeville]]></surname>
<given-names><![CDATA[Hannah R]]></given-names>
</name>
<name>
<surname><![CDATA[Jennifer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sasser. Preeclampsia beyond pregnancy: long-term consequences for mother and child]]></article-title>
<source><![CDATA[Am J Physiol Renal Physiol]]></source>
<year>2020</year>
<volume>318</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>F1315-26</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yanque-Robles]]></surname>
<given-names><![CDATA[Omar]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical practice guideline for the prevention and management of hypertensive disorders of pregnancy.&#8221; &#8220;Guía de práctica clínica para la prevención y el manejo de la enfermedad hipertensiva del embarazo]]></article-title>
<source><![CDATA[Revista Colombiana de Obstetricia y Ginecologia]]></source>
<year>2022</year>
<volume>73</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>48-141</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ma&#8217;ayeh]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rood]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Kniss]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel Interventions for the Prevention of Preeclampsia]]></article-title>
<source><![CDATA[Curr Hypertens Rep]]></source>
<year>2020</year>
<volume>22</volume>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mirabito]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Neuman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Visser]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Jan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Versmissen]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aspirin for the prevention and treatment of pre&#8208;eclampsia: A matter of COX&#8208;1 and/or COX&#8208;2 inhibition?]]></article-title>
<source><![CDATA[Basic Clin Pharmacol Toxicol]]></source>
<year>2020</year>
<volume>127</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>132-41</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Atallah]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lecarpentier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Goffinet]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Doret-Dion]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gaucherand]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Tsatsaris]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aspirin for prevention of preeclampsia]]></article-title>
<source><![CDATA[Drugs]]></source>
<year>2017</year>
<volume>77</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>1819-31</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Urrútia]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bonfill]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis]]></article-title>
<source><![CDATA[Med Clin (Barc)]]></source>
<year>2010</year>
<volume>135</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>507-11</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jadad]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<name>
<surname><![CDATA[Andrew]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Carroll]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Jenkinson]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[John]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Reynolds]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gavaghan]]></surname>
<given-names><![CDATA[HJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessing the quality of reports of randomized clinical trials: Is blinding necessary?]]></article-title>
<source><![CDATA[Controlled Clinical Trials]]></source>
<year>1996</year>
<volume>17</volume>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mervi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Hannu]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Helena]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Seppo]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Sinikka]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Juha]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study]]></article-title>
<source><![CDATA[Human Reproduction]]></source>
<year>2010</year>
<volume>25</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2972-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ashraf]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the effect of metformin and aspirin on utero placental circulation of pregnant women with PCOS]]></article-title>
<source><![CDATA[Iranian J Reprod Med]]></source>
<year>2012</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>265-70</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villa]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Kajantie]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Räikkönen]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Pesonen]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Hämäläinen]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Vainio]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aspirin in the prevention of pre-eclampsia in high-risk women: a randomized placebo-controlled PREDO Trial and a meta-analysis of randomized trials]]></article-title>
<source><![CDATA[BJOG]]></source>
<year>2012</year>
<volume>120</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>64-74</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ayala]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Ucieda]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hermida]]></surname>
<given-names><![CDATA[RC.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chronotherapy With Low-Dose Aspirin for Prevention of Complications in Pregnancy]]></article-title>
<source><![CDATA[Chronobiology International]]></source>
<year>2013</year>
<volume>30</volume>
<page-range>260-7</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Odibo]]></surname>
<given-names><![CDATA[AO]]></given-names>
</name>
<name>
<surname><![CDATA[Goetzinger]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Odibo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Tuuli]]></surname>
<given-names><![CDATA[MG.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early prediction and aspirin for prevention of pre-eclampsia (EPAPP) study: a randomized controlled trial]]></article-title>
<source><![CDATA[Ultrasound Obstet Gynecol]]></source>
<year>2015</year>
<volume>46</volume>
<page-range>414-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of regular oral intake of aspirin during pregnancy on pregnancy outcome of high-risk pregnancy-induced hypertension syndrome patients]]></article-title>
<source><![CDATA[Eur Rev Med Pharmacol Sci]]></source>
<year>2016</year>
<volume>20</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>5013-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rolnik]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Poon]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[O&amp;apos;Gorman]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Syngelaki]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Matallana]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2017</year>
<volume>377</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>613-22</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoffman]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2020</year>
<volume>395</volume>
<numero>10220</numero>
<issue>10220</issue>
<page-range>285-93</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Higgins]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0]]></source>
<year>2011</year>
<volume>0</volume>
<numero>0</numero>
<issue>0</issue>
<page-range>1-639</page-range><publisher-name><![CDATA[The Cochrane Collaboration]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Seidler]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Askie]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ray]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimal aspirin dosing for preeclampsia prevention]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2018</year>
<volume>219</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>117-8</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gan]]></surname>
<given-names><![CDATA[Jie]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[Huan]]></given-names>
</name>
<name>
<surname><![CDATA[Qi.]]></surname>
<given-names><![CDATA[Hongbo]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preventing preeclampsia and its fetal complications with low-dose aspirin in East Asians and non-East Asians: A systematic review and meta-analysis]]></article-title>
<source><![CDATA[Hypertension in Pregnancy]]></source>
<year>2016</year>
<volume>35</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>426-35</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Deng]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low-dose aspirin for preventing preeclampsia and its complications: a meta-analysis]]></article-title>
<source><![CDATA[J Clin Hypertens]]></source>
<year>2015</year>
<volume>17</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>567-73</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Zheng]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low-dose aspirin at &#8804;16 weeks of gestation for preventing preeclampsia and its maternal and neonatal adverse outcomes: A systematic review and meta-analysis]]></article-title>
<source><![CDATA[Exp Ther Med]]></source>
<year>2018</year>
<volume>15</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>4361-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chaemsaithong]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Cuenca]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Plana]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gil]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Poon]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Does low-dose aspirin initiated before 11 weeks&amp;apos; gestation reduce the rate of preeclampsia?]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2020</year>
<volume>222</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>437-50</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roberge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2017</year>
<volume>216</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>110-20</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duley]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiplatelet agents for preventing pre-eclampsia and its complications]]></article-title>
<source><![CDATA[The Cochrane database of systematic reviews]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<collab>US Preventive Services Task Force</collab>
<article-title xml:lang=""><![CDATA[Screening for Preeclampsia]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2017</year>
<volume>317</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>1661-7</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roberge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sibai]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[McCaw]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bujold]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low-dose aspirin in early gestation for prevention of preeclampsia and small-for-gestational-age neonates: meta-analysis of large randomized trials]]></article-title>
<source><![CDATA[Am J Perinatol]]></source>
<year>2016</year>
<volume>33</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>781-5</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roberge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bujold]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Nicolaides]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2018</year>
<volume>218</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>287-93</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Igboanugo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mielke]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maternal risk factors for birth asphyxia in low-resource communities. A systematic review of the literature]]></article-title>
<source><![CDATA[J Obstet Gynaecol]]></source>
<year>2020</year>
<volume>40</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1039-55</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="book">
<collab>Instituto Nacional Materno Perinatal</collab>
<source><![CDATA[Guía de Práctica Clínica para la prevención y manejo de Preeclampsia y Eclampsia. Guía de Práctica Clínica]]></source>
<year>2017</year>
<publisher-loc><![CDATA[Lima ]]></publisher-loc>
<publisher-name><![CDATA[INMP]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
