<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021000400011</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i4.4326</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Coriocarcinoma primario del cuello uterino. Enfermedad extremadamente rara: reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Primary choriocarcinoma of uterine cervix. Extremely rare disease, case presentation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cantón-Romero]]></surname>
<given-names><![CDATA[Juan Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo-Garibaldi]]></surname>
<given-names><![CDATA[Óscar Joel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez-López]]></surname>
<given-names><![CDATA[Guillermo Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salas-González]]></surname>
<given-names><![CDATA[Efraín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Jalisciense de Cancerología  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro de Estudios Especializados de Patología  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>4</numero>
<fpage>350</fpage>
<lpage>356</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021000400011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021000400011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021000400011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES:  El embarazo cervical es una localización extremadamente rara, con incidencia de 1 caso por cada 9000 partos. La asociación con coriocarcinoma es aún más rara. La localización más común del coriocarcinoma es el útero; se puede encontrar en la salpinge, la vagina, la vulva, el cuello uterino o la región pélvica. La quimioterapia es sumamente efectiva para tratar pacientes con coriocarcinoma, con tasas de curación del 100% en condiciones de bajo riesgo y 80 a 90% en alto riesgo.  OBJETIVO:  Determinar el grado de enfermedad y contribuir al conocimiento médico del diagnóstico oportuno y el tratamiento multidisciplinario correcto del coriocarcinoma en una presentación extremadamente rara.  CASO CLÍNICO:  Paciente de 36 años, con aborto completo a las 5.4 semanas de gestación, sin evidencia de embarazo intrauterino. Se trató con misoprostol vaginal y, posteriormente, anticonceptivos durante dos meses. La paciente continuó con escaso sangrado transvaginal y dolor pélvico difuso. La tomografía axial abdomino-pélvica evidenció que en el útero había un tumor de 15 cm a la altura del istmo. Los anexos, el hígado y el retroperitoneo se observaron normales; la hormona gonadotropina coriónica fracción beta (&#946;-hGC) se encontró en 225,000 mUI/mL. Ante el diagnóstico clínico de embarazo ístmico-cervical, paridad satisfecha con antecedente de salpingoclasia y probable coriocarcinoma, se procedió a la histerectomía abdominal simple, sin complicaciones. Recibió quimioterapia con metotrexato y etopósido durante 8 semanas. Al concluir el esquema de quimioterapia la &#946;-hGC se encontró en: 1.28 mUI/mL.  CONCLUSIONES:  El coriocarcinoma cervical es poco frecuente; su localización pone en peligro la vida de las pacientes por el alto riesgo de hemorragia, a pesar de tener buen pronóstico y adecuada respuesta a la quimioterapia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND:  Cervical pregnancy is an extremely rare site, with an incidence of 1 in 9000 deliveries. The association with choriocarcinoma is even rarer. The most common location of choriocarcinoma is the uterus; it can be found in the salpingeum, vagina, vulva, cervix or pelvic region. Chemotherapy is highly effective in treating patients with choriocarcinoma, with cure rates of 100% in low-risk conditions and 80 to 90% in high-risk.  OBJECTIVE:  To determine the extent of disease and contribute to medical knowledge of the timely diagnosis and correct multidisciplinary treatment of choriocarcinoma in an extremely rare presentation.  CLINICAL CASE:  36-year-old female patient with complete abortion at 5.4 weeks of gestation, with no evidence of intrauterine pregnancy. She was treated with vaginal misoprostol and, subsequently, contraceptives for two months. The patient continued with scant transvaginal bleeding and diffuse pelvic pain. Abdomino-pelvic axial tomography showed a 15 cm tumor in the uterus at the level of the isthmus. The adnexa, liver and retroperitoneum were normal; chorionic gonadotrophin hormone beta fraction (&#946;-hGC) was found to be 225,000 mIU/mL. Given the clinical diagnosis of isthmic-cervical pregnancy, satisfied parity with a history of salpingoclasia and probable choriocarcinoma, a simple abdominal hysterectomy was performed without complications. She received chemotherapy with methotrexate and etoposide for 8 weeks. At the conclusion of the chemotherapy scheme the &#946;-hGC was found to be: 1.28 mIUI/mL.  CONCLUSIONS:  Cervical choriocarcinoma is rare; its location endangers the life of patients due to the high risk of hemorrhage, despite having good prognosis and adequate response to chemotherapy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Embarazo]]></kwd>
<kwd lng="es"><![CDATA[coriocarcinoma]]></kwd>
<kwd lng="es"><![CDATA[región pélvica]]></kwd>
<kwd lng="es"><![CDATA[embarazo intrauterino]]></kwd>
<kwd lng="es"><![CDATA[misoprostol vaginal]]></kwd>
<kwd lng="es"><![CDATA[anticonceptivos]]></kwd>
<kwd lng="es"><![CDATA[sangrado]]></kwd>
<kwd lng="es"><![CDATA[dolor pélvico]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Choriocarcinoma]]></kwd>
<kwd lng="en"><![CDATA[Pelvic region]]></kwd>
<kwd lng="en"><![CDATA[Intrauterine pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Vaginal misoprostol]]></kwd>
<kwd lng="en"><![CDATA[Contraceptives]]></kwd>
<kwd lng="en"><![CDATA[Bleeding]]></kwd>
<kwd lng="en"><![CDATA[Pelvic pain]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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