<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021000200176</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i2.4445</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome del varón 46 XX. Reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[46 XX male syndrome. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Téllez-Velasco]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar-López Ortiz]]></surname>
<given-names><![CDATA[Carlos Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Soto]]></surname>
<given-names><![CDATA[Oscar Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuapio-Padilla]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar-Trujillo]]></surname>
<given-names><![CDATA[José Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Español (HISPAREP) Clínica de Reproducción Asistida ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Español (HISPAREP) Clínica de Reproducción Asistida ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Español (HISPAREP) Clínica de Reproducción Asistida ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Español (HISPAREP) Clínica de Reproducción Asistida ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Español  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>2</numero>
<fpage>176</fpage>
<lpage>181</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021000200176&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021000200176&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021000200176&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  ANTECEDENTES: El síndrome del varón 46 XX o síndrome De la Chapelle es una causa infrecuente de azoospermia con incidencia de 1 caso por cada 20,000 nacidos vivos masculinos. Se trata de un trastorno en la diferenciación sexual en el que el fenotipo y el sexo cromosómico no corresponden, por lo que no es una causa común de sospecha de azoospermia.  CASO CLÍNICO:  Paciente de 37 años, con deseo de fertilidad, que durante la revisión clínica se le encontró azoospermia en dos ocasiones. En la exploración física se observó atrofia testicular bilateral, con alopecia fronto temporal. El ultrasonido testicular reportó atrofia bilateral y el perfil hormonal: hipogonadismo hipergonadotrófico. Se diagnosticó: azoospermia de causa no obstructiva. El estudio citogenético informó el cariotipo 46 XX en sangre periférica y pérdida del gen SRY en el de hibridación in situ, que estableció el diagnóstico de síndrome De la Chapelle.  CONCLUSIONES: Este síndrome tiene una baja incidencia por lo que pensarlo como causa de azoospermia no obstructiva requiere conocimientos básicos e integración del algoritmo de estudio.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  BACKGROUND: The 46 XX male syndrome or De la Chapelle syndrome is a rare cause of azoospermia with an incidence of 1 case per 20,000 live male births. It is a disorder of sexual differentiation in which the phenotype and chromosomal sex do not correspond, so it is not a common cause of suspected azoospermia.  CLINICAL CASE: A 37-year-old female patient with fertility desire, who was found to have azoospermia on two measurements during clinical examination. Physical examination showed bilateral testicular atrophy, with frontotemporal alopecia. The testicular ultrasound reported bilateral atrophy and the hormonal profile: hypergonadotrophic hypogonadism. Diagnosis: azoospermia of non-obstructive cause. The cytogenetic study reported karyotype 46XX in peripheral blood and loss of the SRY gene in the in situ hybridization study, which established the diagnosis of Chapelle syndrome.  CONCLUSIONS: This syndrome has a low incidence so thinking of it as a cause of nonobstructive azoospermia requires basic knowledge and integration of the study algorithm.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome del varón 46 XX]]></kwd>
<kwd lng="es"><![CDATA[azoospermia]]></kwd>
<kwd lng="es"><![CDATA[diferenciación sexual]]></kwd>
<kwd lng="es"><![CDATA[atrofia testicular]]></kwd>
<kwd lng="es"><![CDATA[hipogonadismo hipergonadotrófico]]></kwd>
<kwd lng="es"><![CDATA[cariotipo]]></kwd>
<kwd lng="es"><![CDATA[hibridización in situ]]></kwd>
<kwd lng="es"><![CDATA[azoospermia no obstructiva]]></kwd>
<kwd lng="en"><![CDATA[46 XX male syndrome]]></kwd>
<kwd lng="en"><![CDATA[Azoospermia]]></kwd>
<kwd lng="en"><![CDATA[Sexual differentiation]]></kwd>
<kwd lng="en"><![CDATA[Testicular atrophy]]></kwd>
<kwd lng="en"><![CDATA[Hypergonadotrophic]]></kwd>
<kwd lng="en"><![CDATA[Karyotype]]></kwd>
<kwd lng="en"><![CDATA[In situ hybridization]]></kwd>
<kwd lng="en"><![CDATA[nonobstructive azoospermia]]></kwd>
</kwd-group>
</article-meta>
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