<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412020000700003</article-id>
<article-id pub-id-type="doi">10.24245/gom.v88i7.4167</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Prevalencia de infección por genotipos del virus del papiloma humano en mujeres con atipia de células escamosas de significado incierto]]></article-title>
<article-title xml:lang="en"><![CDATA[Prevalence of infection by genotypes of the PVH in women with ASCUS cytology]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina-Bueno]]></surname>
<given-names><![CDATA[Gonzalo Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de San Agustín  ]]></institution>
<addr-line><![CDATA[Arequipa ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>88</volume>
<numero>7</numero>
<fpage>437</fpage>
<lpage>441</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412020000700003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412020000700003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412020000700003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO:  Estimar la prevalencia de infección por genotipos del virus del papiloma humano en mujeres con atipia de células escamosas de significado incierto.  MATERIALES Y MÉTODO:  Estudio transversal, descriptivo y retrospectivo efectuado mediante el análisis de los registros de la prueba 21-PVH-Genoarray de Hybriobio en mujeres mayores de 18 años, referidas al servicio de Ginecología del Hospital Nacional Carlos Alberto Seguín, durante el año 2018, debido a atipia de células escamosas de significado incierto. Se utilizó el sistema Genoarray-Hybribio para el genotipado. Variables de estudio: genotipos de VPH de alto riesgo, VPH de bajo riesgo y edad. Se estimaron proporciones y razón de momios con IC95%.  RESULTADOS:  Se estudiaron 227 pacientes: 95 resultaron con prueba positiva para VPH (41.8%). La prevalencia de genotipos de alto riesgo fue de 33.9%. Los más frecuentes fueron: 16, 31, 52 y 53. La prevalencia fue de 4.8% para los genotipos de bajo riesgo: 81, 6, 43 y 11, y 3.1% fueron infecciones mixtas. Se registraron 38 mujeres con infección con al menos dos genotipos. Las mujeres mayores de 30 años tuvieron 3 veces más riesgo de infección por genotipos de alto riesgo. La razón de momios fue 3.32 (IC95%: 1.21-9.10) en relación con las menores de 30 años, asociación estadística significativa p &lt; 0.01.  CONCLUSIONES:  La prevalencia global fue: 41.8%, la infección por VPH de alto riesgo en mujeres con atipia de células escamosas de significado incierto fue 33.9%. Los genotipos más prevalentes en infecciones únicas fueron: 16, 31, 52 y 53.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE:  To estimate the prevalence of infection by genotypes of the human papilloma virus in women with squamous cell atypia of unknown significance (ASCUS).  MATERIALS AND METHOD:  Transversal and cross-sectional study of patients referred to the Carlos Alberto Seguín National Hospital, during 2018, for presenting ASCUS cytology, the Genoarray-Hybribio system for genotyping was reported. The study variables were: high-risk HPV genotypes, low-risk HPV, and age. Proportions and odds ratios were estimated with 95% confidence intervals.  RESULTS:  227 patients were studied, of which 95 had a positive test for HPV (41.8%). The prevalence for high-risk genotypes was 33.9%. The most frequent being 16, 31, 52 and 53. The prevalence was 4.8% for low-risk genotypes: 81, 6, 43, and 11, and 3.1% were mixed infections. 38 women had infection with less than two genotypes, women older than 30 years were 3 times more at risk of infection due to high-risk genotypes, Odss ratio 3.32 (95% CI 1.21-9.10) in relation to those younger than 30 years, statistical association significant p &lt;0.01.  CONCLUSIONS:  The overall prevalence was 41.8%, the high-risk HPV infection in women with ASCUS was 33.9%, with the genotypes most prevalent in single infections being 16, 31, 52, and 53.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Prevalencia]]></kwd>
<kwd lng="es"><![CDATA[genotipos]]></kwd>
<kwd lng="es"><![CDATA[mujeres]]></kwd>
<kwd lng="es"><![CDATA[ASCUS]]></kwd>
<kwd lng="es"><![CDATA[infecciones mixtas]]></kwd>
<kwd lng="es"><![CDATA[infección por virus del papiloma]]></kwd>
<kwd lng="en"><![CDATA[Prevalence]]></kwd>
<kwd lng="en"><![CDATA[Genotypes]]></kwd>
<kwd lng="en"><![CDATA[Women]]></kwd>
<kwd lng="en"><![CDATA[ASCUS]]></kwd>
<kwd lng="en"><![CDATA[Mixed Infections]]></kwd>
<kwd lng="en"><![CDATA[Papillomavirus Infection]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arbyn]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis]]></article-title>
<source><![CDATA[Lancet Glob Health]]></source>
<year>2020</year>
<volume>8</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>e191-203</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruni]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings]]></article-title>
<source><![CDATA[J Infect Dis]]></source>
<year>2010</year>
<volume>202</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1789-99</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Walboomers]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human papillomavirus is a necessary cause of invasive cervical cancer worldwide]]></article-title>
<source><![CDATA[J Pathol]]></source>
<year>1999</year>
<volume>189</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>12-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Piñeros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cancer patterns, trends, and transitions in Peru: a regional perspectivel]]></article-title>
<source><![CDATA[The Lancet Oncology]]></source>
<year>2017</year>
<volume>18</volume>
<numero>10</numero>
<issue>10</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robles]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alternative HPV vaccination schedules in Latin America]]></article-title>
<source><![CDATA[Salud Pública Mex]]></source>
<year>2018</year>
<volume>60</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>693-702</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alameda]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Citología en medio líquido (ThinPrep PapTest). Un año de experiencia]]></article-title>
<source><![CDATA[Prog Obstet Ginecol]]></source>
<year>2007</year>
<volume>50</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>197-202</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Srodon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Atypical Squamous Cells, Cannot Exclude High-Grade Squamous Intraepithelial Lesion: Diagnostic Performance, Human Papillomavirus Testing, and Follow-Up Results]]></article-title>
<source><![CDATA[Cancer]]></source>
<year>2006</year>
<volume>108</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>32-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-Portilla]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia de serotipos de VPH de alto riesgo detectados por PCR en pacientes con citología normal del Hospital Regional Adolfo López Mateos, ISSSTE]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2016</year>
<volume>84</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>556-61</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heredia-Caballero]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia y tipificación de genotipos de virus del papiloma humano en mujeres del área metropolitana del Valle de México]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2017</year>
<volume>85</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>809-18</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characteristics of women infected with human papillomavirus in a tertiary Hospital in Beijing China, 2014-2018]]></article-title>
<source><![CDATA[BMC Infect Dis]]></source>
<year>2019</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Manrique-Hinojosa]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detección del virus del papiloma humano en muestras obtenidas mediante técnica de autotoma en un grupo de universitarias peruanas]]></article-title>
<source><![CDATA[Rev. perú. med. exp. salud publica]]></source>
<year>2018</year>
<volume>35</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detección del VPH en mujeres con y sin alteraciones citológicas del cérvix en Castilla y León: estudio poblacional]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2017</year>
<volume>85</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>217-23</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salcedo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human papillomavirus genotypes among females in Mexico: a study from the Mexican Institute for Social Security]]></article-title>
<source><![CDATA[Asian Pac J Cancer Prev]]></source>
<year>2014</year>
<volume>15</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>10061-6</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paz-Zulueta]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia de genotipos no vacunados de alto riesgo del virus del papiloma humano en el programa de detección precoz del cáncer de cuello uterino en Cantabria]]></article-title>
<source><![CDATA[Aten Primaria]]></source>
<year>2016</year>
<volume>48</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>347-55</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres-Ibarra]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Triage strategies in cervical cancer detection in Mexico: Methods of the FRIDA Study]]></article-title>
<source><![CDATA[Salud Publica Mex]]></source>
<year>2016</year>
<volume>58</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>197-210</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández-Montolí]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-term predictors of residual or recurrent cervical intraepithelial neoplasia 2-3 after treatment with a large loop excision of the transformation zone: a retrospective study]]></article-title>
<source><![CDATA[BJOG]]></source>
<year>2020</year>
<volume>127</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>377-87</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tejada]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human papillomavirus vaccine efficacy in the prevention of anogenital warts: Systematic review and meta-analysis]]></article-title>
<source><![CDATA[Salud Publica Mex]]></source>
<year>2017</year>
<volume>59</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>84-94</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Egli-Gany]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human Papillomavirus Genotype distribution and socio-behavioural characteristics in women with cervical pre-cancer and cancer at the start of a human papillomavirus vaccination-programme: The CIN3+ Plus Study]]></article-title>
<source><![CDATA[BMC Cancer]]></source>
<year>2019</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>111</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
