<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412020000600402</article-id>
<article-id pub-id-type="doi">10.24245/gom.v88i6.3945</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Melanoma vaginal. Reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Vaginal melanoma. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguirre-García]]></surname>
<given-names><![CDATA[Rosaura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña-Vega]]></surname>
<given-names><![CDATA[Cynthia Jazmín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Figueroa]]></surname>
<given-names><![CDATA[Rafael Buitrón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muñoz-Cortés]]></surname>
<given-names><![CDATA[Sergio Bruno]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alemán-Ceballos]]></surname>
<given-names><![CDATA[Erika]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arrecillas-Zamora]]></surname>
<given-names><![CDATA[Myrna Doris]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud Hospital General de México Dr. Eduardo Liceaga ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Salud Hospital General de México Dr. Eduardo Liceaga ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Secretaría de Salud Hospital General de México Dr. Eduardo Liceaga ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>88</volume>
<numero>6</numero>
<fpage>402</fpage>
<lpage>406</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412020000600402&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412020000600402&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412020000600402&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  ANTECEDENTES: El melanoma vaginal es una alteración excepcional, por lo que el diagnóstico se establece en etapas avanzadas de la enfermedad. El pronóstico a corto plazo es malo y no existen factores de riesgo identificados hasta la fecha.  CASO CLINICO: Paciente de 77 años, acudió a consulta por sangrado transvaginal fétido, de dos meses de evolución. Durante la colposcopia se observó una tumoración en la cara lateral izquierda de la vagina, que se extendía hasta su tercio inferior; la cara anterior estaba hiperpigmentada y friable. De acuerdo con el reporte de citología y la biopsia se estableció el diagnóstico de melanoma invasor. La concentración de marcadores tumorales fue positiva para HMB-45, Ki-67 (20%), MART-1 (Melan-1) y PS-100. La paciente fue enviada al servicio de Oncología para estadificación y tratamiento de la enfermedad.  CONCLUSIONES: La identificación de una tumoración hiperpigmentada en la exploración ginecológica, además de la biopsia dirigida complementada con estudio de inmunohistoquímica, es sugerente de melanoma vaginal. Las pacientes con este tipo de lesión deben atenderse por un equipo médico multidisciplinario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  BACKGROUND: Vaginal melanoma is an exceptional alteration, for which the diagnosis is established in advanced stages of the disease. The short-term prognosis is poor and there are no identified risk factors to date.  CLINICAL CASE:  77-year-old patient, who came to the clinic for fetid transvaginal bleeding, two months old. During colposcopy, a tumor was observed on the left lateral aspect of the vagina, which extended to its lower third; the anterior face was hyperpigmented and friable. Based on the cytology report and biopsy, the diagnosis of invasive melanoma was established. The concentration of tumor markers was positive for HMB-45, Ki 67 (20%), MART-1 (Melan-1) and PS-100. The patient was sent to the Oncology service for staging and treatment of the disease.  CONCLUSIONS:  The identification of a hyperpigmented tumor on gynecological examination, in addition to a directed biopsy, complemented by an immunohistochemical study, is suggestive of vaginal melanoma. Patients with this type of injury should be cared for by a multidisciplinary medical team.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Melanoma vaginal]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="es"><![CDATA[colposcopia]]></kwd>
<kwd lng="es"><![CDATA[melanoma invasor]]></kwd>
<kwd lng="es"><![CDATA[marcadores tumorales]]></kwd>
<kwd lng="es"><![CDATA[biomarcador Ki-67]]></kwd>
<kwd lng="es"><![CDATA[biopsia]]></kwd>
<kwd lng="es"><![CDATA[exploración ginecológica]]></kwd>
<kwd lng="en"><![CDATA[Vaginal melanoma]]></kwd>
<kwd lng="en"><![CDATA[Risk factors]]></kwd>
<kwd lng="en"><![CDATA[Colposcopy]]></kwd>
<kwd lng="en"><![CDATA[Invasive melanoma]]></kwd>
<kwd lng="en"><![CDATA[Tumor markers]]></kwd>
<kwd lng="en"><![CDATA[Ki-67 biomarker]]></kwd>
<kwd lng="en"><![CDATA[biopsy]]></kwd>
<kwd lng="en"><![CDATA[Gynecological examination]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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