<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412018001200810</article-id>
<article-id pub-id-type="doi">10.24245/gom.v86i12.1814</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diagnóstico prenatal de un feto con doble trisomía con cariotipo 48 XXX +18: reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Prenatal diagnosis of a fetus with double trisomy with karyotype 48 XXX +18: A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casillas-Barrera]]></surname>
<given-names><![CDATA[Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-Morales]]></surname>
<given-names><![CDATA[Martha P]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Farías-Barajas]]></surname>
<given-names><![CDATA[Madaí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Gómez]]></surname>
<given-names><![CDATA[Claudia Nathanael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Morales]]></surname>
<given-names><![CDATA[Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de la Mujer  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de la Mujer  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital de la Mujer  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2018</year>
</pub-date>
<volume>86</volume>
<numero>12</numero>
<fpage>810</fpage>
<lpage>814</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412018001200810&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412018001200810&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412018001200810&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: El diagnóstico prenatal de doble aneuploidia es muy raro, incluso la variante de doble trisomía, que implica la expresion de los cromosomas 18 y X.  CASO CLÍNICO:  Paciente de 43 años, con antecedentes ginecoobstétricos de cuatro embarazos y tres partos, enviada de su centro de salud, en curso del cuarto embarazo. A su ingreso al Hospital de la Mujer, el estudio ecográfico reportó un embarazo de 24.3 semanas de gestación, con feto único, clinodactilia, miembro pélvico derecho con pie equino varo, probable atresia esofágica (ausencia de cámara gástrica, polihidramnios) y cordón umbilical con arteria única. Se estableció el diagnóstico de doble trisomía (48XXX +18) mediante estudio citogenético en líquido amniótico. En la semana 34 acudió al servicio de Urgencias con trabajo de parto en periodo expulsivo y ausencia de vitalidad fetal. La pareja no aceptó el estudio anatomopatológico.  CONCLUSION: El diagnóstico prenatal de doble trisomía es raro de establecer en el segundo trimestre del embarazo; su detección oportuna proporciona información valiosa para establecer el pronóstico fetal y ofrecer asesoría genética adecuada. Este caso quizá corresponde al primero documentado en México y el quinto en todo el mundo, diagnosticado mediante estudio citogenético.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Prenatal diagnosis of double trisomy is rare, particular uncommon simultaneous occurrence of double trisomy involving chromosomes 18 and X.  CLINICAL CASE:  A 43-year-old patient, with a gyneco-obstetric history of four pregnancies and three deliveries, sent from her health center during the fourth pregnancy. Upon admission to the Women's Hospital, the ultrasound study reported a pregnancy of 24.3 weeks of gestation, with a single fetus, clinodactyly, right pelvic member with equinus varus foot, probable esophageal atresia (absence of gastric chamber, polyhydramnios), and umbilical cord. with a single artery. The diagnosis of double trisomy (48XXX +18) was established by cytogenetic study in amniotic fluid. In the week 34, she went to the Emergency Department with labor in the expulsive period and absence of fetal vitality. The couple did not accept the anatomopathological study.  CONCLUSION: Prenatal diagnosis of double trisomy is rare in the second trimester of pregnancy, its detection is important because it provides valuable information to establish the fetal prognosis and provide adequate genetic counseling. This case is relevant because it is probably the first documented in Mexico and the fifth internationally diagnosed prenatally by cytogenetic study.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Doble trisomía]]></kwd>
<kwd lng="es"><![CDATA[aneuploidia]]></kwd>
<kwd lng="es"><![CDATA[trisomía 18]]></kwd>
<kwd lng="es"><![CDATA[trisomía X]]></kwd>
<kwd lng="en"><![CDATA[Double trisomy]]></kwd>
<kwd lng="en"><![CDATA[Aneuploidy]]></kwd>
<kwd lng="en"><![CDATA[Trisomy 18]]></kwd>
<kwd lng="en"><![CDATA[Trisomy X]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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