<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412017000800525</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores de riesgo asociados con el aumento de progesterona el día de la aplicación de hCG en protocolos de estimulación con un antagonista para fertilización in vitro]]></article-title>
<article-title xml:lang="en"><![CDATA[Risk factors associated with increased progesterone on the day of hCG application in stimulation protocols with an antagonist for in vitro fertilization]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carballo-Mondragón]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roque-Sánchez]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soriano-Ortega]]></surname>
<given-names><![CDATA[KP]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Durán-Monterrosas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kably-Ambe]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles Lomas Centro de Fertilidad del CEPAM ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<volume>85</volume>
<numero>8</numero>
<fpage>525</fpage>
<lpage>530</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412017000800525&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412017000800525&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412017000800525&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: se ha reportado el efecto adverso de la elevación prematura de las concentraciones de progesterona durante la fase folicular de un ciclo de fertilización in vitro. Hasta el momento no existen estudios que evalúen los factores de riesgo asociados con esta elevación.  OBJETIVO: evaluar los factores de riesgo asociados con la elevación prematura de las concentraciones de progesterona durante la fase folicular en ciclos de estimulación ovárica para fertilización in vitro con un fármaco antagonista en esquema flexible.  MATERIALES Y METODOS: estudio retrospectivo, observacional y transversal de ciclos de fertilización in vitro, efectuado en el Centro Mexicano de Fertilidad del CEPAM, de enero de 2009 a febrero de 2014. Criterios de inclusión: pacientes que recibieron un protocolo de estimulación ovárica con un antagonista de GnRH en esquema flexible.  RESULTADOS: se analizaron 469 ciclos de fertilización in vitro. Las principales variables relacionadas con las concentraciones de progesterona el día de la aplicación de hCG fueron: IMC (r=-0.96), estradiol basal (r=0.94), edad de la mujer (r= -0.7) y pico máximo de estradiol (r=0.89). No se encontró correlación con las concentraciones de FSH y LH basales, ni con la dosis total de gonadotropinas.  CONCLUSION: las pacientes de menor edad e IMC, además de concentraciones basales elevadas y pico máximo de estradiol suelen tener concentraciones altas de progesterona el día de la aplicación de hCG.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: It is well known that premature luteinization has a deletereous efecto on the outcome of IVF cycles however there are no reports that evaluate associated risk factor.  OBJECTIVE: To evaluate factors associated to premature luteinization during folicular phase of IVF cycles under antagonist stimulation protocol.  MATERIAL AND METHODS:  This is a comparative, retrospective, observational study. 469 IVF flexible-antagonist protocol cycles were included from January 2009 to February 2014.  RESULTS: We registered 469 IVF cycles. The IMC, basal estradiol, age and estradiol on trigger date showed correlation with premature luteinization. There were no association with basal FSH and LH nor total gonadotropin dose.  CONCLUSION: Lowe age and IMC and higher estradio levels are associated to a higer level of progesterone on trigger date.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[fertilización in vitro]]></kwd>
<kwd lng="es"><![CDATA[progesterona]]></kwd>
<kwd lng="es"><![CDATA[fármaco antagonista]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="en"><![CDATA[In vitro fertilization]]></kwd>
<kwd lng="en"><![CDATA[Progesterone]]></kwd>
<kwd lng="en"><![CDATA[Antagonist drug]]></kwd>
<kwd lng="en"><![CDATA[Risk factors]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Chai]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yeung]]></surname>
<given-names><![CDATA[TW]]></given-names>
</name>
<name>
<surname><![CDATA[Yeung]]></surname>
<given-names><![CDATA[WS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen-thawed embryo transfer in natural cycles]]></article-title>
<source><![CDATA[Fertil Steril]]></source>
<year>2014</year>
<volume>101</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1288-93</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van Vaerenbergh]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Fatemi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Blockeel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Van Lommel]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[In't Veld]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Schuit]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression]]></article-title>
<source><![CDATA[Reprod Biomed Online]]></source>
<year>2011</year>
<volume>22</volume>
<page-range>263-71</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Venetis]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Kolibianakis]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Papanikolaou]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bontis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Devroey]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Tarlatzis]]></surname>
<given-names><![CDATA[BC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Is P elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization A systematic review and meta-analysis]]></article-title>
<source><![CDATA[Hum Reprod Update]]></source>
<year>2007</year>
<volume>13</volume>
<page-range>343-55</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Qiao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zhen]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum progesterone concentration on day of HCG administration and IVF outcome]]></article-title>
<source><![CDATA[Reprod Biomed Online]]></source>
<year>2008</year>
<volume>16</volume>
<page-range>627-31</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Papanikolaou]]></surname>
<given-names><![CDATA[EG]]></given-names>
</name>
<name>
<surname><![CDATA[Kolibianakis]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Pozzobon]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Tank]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Tournaye]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Bourgain]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progesterone rise on the day of human chorionic gonad- otropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer]]></article-title>
<source><![CDATA[Fertil Steril]]></source>
<year>2009</year>
<volume>91</volume>
<page-range>949-52</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Macklon]]></surname>
<given-names><![CDATA[NS]]></given-names>
</name>
<name>
<surname><![CDATA[Stouffer]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Giudice]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fauser BCJM: The Science behind 25 years of Ovarian Stimulation for In Vitro Fertilization]]></article-title>
<source><![CDATA[Endocr Rev]]></source>
<year>2006</year>
<volume>27</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>170-207</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fleming]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jenkins]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The source and implications of progesterone rise during the follicular phase of assisted reproduction cycle]]></article-title>
<source><![CDATA[Reprod Biomed Online]]></source>
<year>2010</year>
<volume>21</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>446-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Lien]]></surname>
<given-names><![CDATA[YR]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[HF]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Shieh]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Yao]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The duration of pre- ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles]]></article-title>
<source><![CDATA[Hum Reprod]]></source>
<year>2012</year>
<volume>27</volume>
<page-range>2036-45</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bosch]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Labarta]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Crespo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Remohi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jenkins]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization analysis of over 4000 cycles]]></article-title>
<source><![CDATA[Hum Reprod]]></source>
<year>2010</year>
<volume>25</volume>
<page-range>2092-100</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fanchin]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Righini]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Olivennes]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[De Ziegler]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Selva]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Frydman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Premature progesterone elevation does not alter oocyte quality in in vitro fertilization]]></article-title>
<source><![CDATA[Fertil Steril]]></source>
<year>1996</year>
<volume>65</volume>
<page-range>1178-83</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
