<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-9532</journal-id>
<journal-title><![CDATA[Revista mexicana de ingeniería biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. ing. bioméd]]></abbrev-journal-title>
<issn>0188-9532</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Ingeniería Biomédica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-95322019000100006</article-id>
<article-id pub-id-type="doi">10.17488/rmib.40.1.6</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Más Allá de La Filogenética: Evolución Darwiniana de La Actina]]></article-title>
<article-title xml:lang="en"><![CDATA[Beyond Phylogenetics: Darwinian Evolution of Actin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moret]]></surname>
<given-names><![CDATA[Marcelo A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zebende]]></surname>
<given-names><![CDATA[Gilney]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Phillips]]></surname>
<given-names><![CDATA[James C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Toledo-Marín]]></surname>
<given-names><![CDATA[J. Quetzalcóatl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Naumis]]></surname>
<given-names><![CDATA[Gerardo G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade do Estado da Bahia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,State University of Feira de Santana Department of Physics ]]></institution>
<addr-line><![CDATA[Bahia ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Rutgers University  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>USA</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Física ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>40</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-95322019000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-95322019000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-95322019000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La actina es una proteína que se polimeriza para formar citoesqueletos y cuya función es estabilizar y dirigir el movimiento de las paredes celulares. Es una de las proteínas más estables, habiendo evolucionado poco a partir de algas y levaduras, y muy poco desde los peces. Aquí analizamos la evolución de la actina usando las teorías modernas de las interacciones de conformación proteína-agua, y cómo estas han evolucionado para optimizar las funciones de la proteína. Llegamos a la conclusión de que el fracaso del análisis filogenético para identificar positivamente la evolución darwiniana de las proteínas ha sido causado por las limitaciones técnicas propias del siglo XX. Estas limitaciones pueden ser superadas mediante el escalamiento termodinámico y el promedio modular ambos llevados a niveles técnicos del siglo XXI. Los resultados para la actina son especialmente llamativos y reflejan estructuras duales estables, globulares y polimerizadas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Actin polymerizes to form cytoskeletons which stabilize and direct motion of cellular walls. It is one of the most stable proteins, having evolved little from algae and yeast, and very little from fish. Here we analyze actin evolution using modern theories of water-protein shaping interactions, and how these have evolved to optimize protein functions. We conclude that the failure of phylogenetic analysis to identify positive Darwinian evolution has been caused by 20th century technical limitations. These are overcome using 21st century thermodynamic scaling and modular averaging. The results for actin are especially striking, and reflect dual stable structures, globular and polymerized.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[proteínas]]></kwd>
<kwd lng="es"><![CDATA[evolución Darwiniana]]></kwd>
<kwd lng="es"><![CDATA[actina]]></kwd>
<kwd lng="en"><![CDATA[proteins]]></kwd>
<kwd lng="en"><![CDATA[Darwinian evolution]]></kwd>
<kwd lng="en"><![CDATA[actin]]></kwd>
</kwd-group>
</article-meta>
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