<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-9532</journal-id>
<journal-title><![CDATA[Revista mexicana de ingeniería biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. ing. bioméd]]></abbrev-journal-title>
<issn>0188-9532</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Ingeniería Biomédica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-95322017000100288</article-id>
<article-id pub-id-type="doi">10.17488/rmib.38.1.24</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Adhesión y proliferación de las células troncales mesenquimales de médula ósea en andamios fibrilares de poli (ácido L-láctico) (PLA)]]></article-title>
<article-title xml:lang="en"><![CDATA[Adhesion and proliferation of bone marrow mesenchymal stem cells onto poli-L lactic acid (PLA) fiber scaffolds]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Granados]]></surname>
<given-names><![CDATA[M.V.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montesinos-Montesinos]]></surname>
<given-names><![CDATA[J.J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Pérez]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM Facultad de Odontología ]]></institution>
<addr-line><![CDATA[ CDMX]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM Facultad de Ciencias ]]></institution>
<addr-line><![CDATA[ CDMX]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,IMSS Centro Médico Nacional Hospital de Oncología]]></institution>
<addr-line><![CDATA[ CDMX]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>38</volume>
<numero>1</numero>
<fpage>288</fpage>
<lpage>296</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-95322017000100288&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-95322017000100288&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-95322017000100288&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los andamios fibrilares han recibido un enorme interés como futuros biomateriales con potencial aplicación en el campo de la biomedicina regenerativa. En este sentido, hemos optimizado los parámetros para la síntesis de diferentes concentraciones (6, 7, y 10 %) de andamios de ácido poli-láctico (PLA) por la técnica de hilado por propulsión de gas (AJS). Dichos andamios fueron caracterizados por Microscopía Electrónica de Barrido (SEM) y por espectrometría Infrarroja con Transformada de Fourier (FTIR). Nuestros resultados mostraron que los andamios son fibrilares con diámetros en escalas nanométricas. Asimismo; se estudió la biocompatibilidad celular in vitro al realizar ensayos de adhesión, proliferación y de interacción célula-material al cultivar células troncales mesenquimales derivadas de médula ósea. Nuestros datos indican que las membranas fibrilares de PLA aumentan la respuesta celular, no son citotóxicas al compararse con las películas delgadas de PLA. Por lo tanto; el método de síntesis propuesto tiene potencial para la fabricación de membranas hiladas con una facilidad de procesamiento y podría ser un prometedor biomaterial económico con futuras aplicaciones en la regeneración de tejidos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Fiber scaffolds have received increasing interest as promising biomaterials for potential application in the field of tissue regeneration. In this sense, we optimized the parameters for the synthesis of different concentrations (6, 7, and 10 %) of poly-lactic acid (PLA) scaffolds by air jet spinning technology (AJS). The PLA scaffolds were characterized by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) analysis. Our results by SEM micrographs showed that scaffolds have a fibrilar morphology with nanoscale diameter of fibers. Biocompatibility assay was observed through an in vitro experiment based on cell attachment, MTT and cell-material interaction assay when culturing bone marrow-derived mesenchymal stem cells onto the PLA spun membrane scaffolds. Our data indicate that fiber membrane of PLA scaffold increase the cellular response, are not cytotoxic when compared to thin films of PLA. Thus; the proposed synthesis method has potential for easy processing of spun fibrilar scaffolds with good biocompatibility and could be a promising economical biomaterial with future potential applications in tissue regeneration.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Andamios]]></kwd>
<kwd lng="es"><![CDATA[Células Troncales Mesenquimales]]></kwd>
<kwd lng="es"><![CDATA[Hilado por propulsión de gas]]></kwd>
<kwd lng="es"><![CDATA[Biocompatibilidad]]></kwd>
<kwd lng="en"><![CDATA[Scaffolds]]></kwd>
<kwd lng="en"><![CDATA[Mesenchymal Stem Cells]]></kwd>
<kwd lng="en"><![CDATA[Air Jet Spinning]]></kwd>
<kwd lng="en"><![CDATA[Biocompatibility]]></kwd>
</kwd-group>
</article-meta>
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