<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-9532</journal-id>
<journal-title><![CDATA[Revista mexicana de ingeniería biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. ing. bioméd]]></abbrev-journal-title>
<issn>0188-9532</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Ingeniería Biomédica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-95322016000200135</article-id>
<article-id pub-id-type="doi">10.17488/rmib.37.2.1</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desarrollo de un Simulador de los Experimentos Clásicos y Actualizados de Fijación de Voltaje de Hodgkin y Huxley]]></article-title>
<article-title xml:lang="en"><![CDATA[Developing a simulation program for classic and updated Hodgkin and Huxley's voltage clamp experiments]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Lazalde]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Monreal]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Bonilla]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,BUAP Escuela de Biología Laboratorio de Biología Interactiva]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,BUAP Dirección General de Innovación Educativa ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2016</year>
</pub-date>
<volume>37</volume>
<numero>2</numero>
<fpage>135</fpage>
<lpage>148</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-95322016000200135&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-95322016000200135&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-95322016000200135&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los estudios de Hodgkin y Huxley fueron el punto de partida de la generación de modelos matemáticos que explican, reproducen y predicen los resultados experimentales del comportamiento de los canales iónicos sensibles a voltaje del axón. Los altos costos de estos experimentos impiden su implementación en la práctica docente de licenciatura. Una alternativa didáctica son los experimentos virtuales mediante simuladores computacionales. En este trabajo se presenta el desarrollo de un simulador que reproduce paso a paso los experimentos clásicos de Hodgkin y Huxley sobre las conductancias de los canales dependientes de voltaje del axón gigante de calamar. El simulador fue desarrollado en lenguaje Visual Basic ver 5.0 para ambiente Wiindows® . Está formado de cuatro módulos: (1) simulación de corrientes iónicas; (2) experimentos clásicos de Hodgkin y Huxley; (3) versión actual del modelo; (4) potenciales de acción. Consta de pantallas de interfaz que permiten simular y calcular los valores de las variables relacionadas con la conductancia de los canales. El usuario puede realizar una cantidad ilimitada de experimentos virtuales que le facilitarán la comprensión del tema.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Hodgkin and Huxley &#769;s works were the starting point to generating mathematical models for explain, reproduce the experimental results and predict the behavior of voltage-sensitive ion channels in the axon. The high costs of these experiments avoid its implementation in teaching degree. An educational alternative is virtual experiments using computer simulations. In this work the development of a simulator that reproduces step by step the classic experiments of Hodgkin and Huxley on the conductance of voltage-dependent channels in squid giant axon is presented. The simulator was developed in Visual Basic language, ver 5.0 for Windows environment. It consists of four modules: (1) ionic currents simulation; (2) classical Hodgkin and Huxley &#769;s experiments; (3) current version model; (4) action potentials. It comprises connecting interface screens that allow simulate and compute the values of the variables associated with the channel conductance. The user can perform an unlimited number of virtual experiments that will facilitate the understanding of the subject.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hodgkin y Huxley]]></kwd>
<kwd lng="es"><![CDATA[simulación biofísica]]></kwd>
<kwd lng="es"><![CDATA[experimentos virtuales]]></kwd>
<kwd lng="es"><![CDATA[canales iónicos]]></kwd>
<kwd lng="en"><![CDATA[Hodgkin and Huxley]]></kwd>
<kwd lng="en"><![CDATA[biophysics simulation]]></kwd>
<kwd lng="en"><![CDATA[virtual experiments]]></kwd>
<kwd lng="en"><![CDATA[ion channels]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Alternative paradigms for ion channelopathies: Disorders of ion channel membrane trafficking and posttranslational modification]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Curran]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mohler]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Annu. Rev. Physiol.]]></source>
<year>2015</year>
<volume>77</volume>
<page-range>.1-9.20</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neurological channel- opathies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kullmann]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann. Rev. Neurosci.]]></source>
<year>2010</year>
<volume>33</volume>
<page-range>151-72</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Teaching basic principles of neuroscience with computer simulations]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Av-Ron]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Byrne]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Baxter]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
</person-group>
<source><![CDATA[JUNE]]></source>
<year>2006</year>
<volume>4</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>A40-52</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<article-title xml:lang=""><![CDATA[An quantitative electro- physiology training resource for simulation-based teaching and learning]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Demir]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
</person-group>
<source><![CDATA[Conf. Proc. IEEE Eng. Med. Biol. Soc. IEEE]]></source>
<year>2004</year>
<volume>7</volume>
<page-range>5169-71</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Electrophysiology course with quantitative method]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Qing-li]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
</person-group>
<source><![CDATA[ITIME]]></source>
<year>2009</year>
<volume>1</volume>
<page-range>706-10</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alegría-Baños]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Álvares-Romo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Arredondo-Mendoza]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Manual de prácticas de laboratorio de fisiología]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Theory and simulation in neuroscience]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gerstner]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Sprekeler]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Deco]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2012</year>
<volume>338</volume>
<page-range>60-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Teaching and learning the Hodgkin-Huxley model based on software developed in NEURON&#8217;s programming language hoc]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[OE]]></given-names>
</name>
<name>
<surname><![CDATA[Zurek]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
</person-group>
<source><![CDATA[BMC Med. Educ]]></source>
<year>2013</year>
<volume>13</volume>
<numero>70</numero>
<issue>70</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carnevale]]></surname>
<given-names><![CDATA[NT]]></given-names>
</name>
<name>
<surname><![CDATA[Hines]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<source><![CDATA[The neuron book]]></source>
<year>2006</year>
<publisher-loc><![CDATA[New York, NY ]]></publisher-loc>
<publisher-name><![CDATA[Cambridge University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Teaching cardiovascular physiology with equivalent electronic circuits in a practically oriented teaching module]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ribaric]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kordas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Adv. Physiol. Educ]]></source>
<year>2011</year>
<volume>35</volume>
<page-range>149-60</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bower]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Beeman]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[The book of GENESIS]]></source>
<year>1998</year>
<edition>2</edition>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[TELOS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Currents carried by sodium and potassium ions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodgkin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Huxley]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Physiol]]></source>
<year>1952</year>
<volume>116</volume>
<page-range>449-72</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The components of membrane conductance in the giant axon of Loligo]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodgkin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Huxley]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Physiol]]></source>
<year>1952</year>
<volume>116</volume>
<page-range>473-96</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The dual effect of membrane potential on sodium conductance in the giant axon of Loligo]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodgkin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Huxley]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Physiol]]></source>
<year>1952</year>
<volume>116</volume>
<page-range>497-506</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Quantitative description of membrane current and its application to conduction and excitation in nerve]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodgkin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Huxley]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Physiol]]></source>
<year>1952</year>
<volume>117</volume>
<page-range>500-44</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Johnston]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
</person-group>
<source><![CDATA[Foundations of cel lular neurophysiology]]></source>
<year>1995</year>
<publisher-loc><![CDATA[Cambridge (Massachusetts) ]]></publisher-loc>
<publisher-name><![CDATA[MIT Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Computer-based alternatives in higher education: past, present and future]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dewhurst]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[ALTEX]]></source>
<year>2006</year>
<volume>23</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>197-201</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Race]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[The Open Learning Handbook]]></source>
<year>1994</year>
<publisher-loc><![CDATA[London ]]></publisher-loc>
<publisher-name><![CDATA[Kogan Page]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Teaching physics in the virtual university: the mechanics toolkit]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heerman]]></surname>
<given-names><![CDATA[DW]]></given-names>
</name>
<name>
<surname><![CDATA[Fuhrmann]]></surname>
<given-names><![CDATA[TT]]></given-names>
</name>
</person-group>
<source><![CDATA[Comput. Phys. Commun]]></source>
<year>2000</year>
<volume>127</volume>
<page-range>11-5</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The use of microcomputer simulations in undergraduate neuro- physiology experiments]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clarke]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[ATLA]]></source>
<year>1987</year>
<volume>14</volume>
<page-range>134-40</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Microcomputer simulations of laboratory experiments in physiology]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dewhurst]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Mehan]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
</person-group>
<source><![CDATA[ATLA]]></source>
<year>1998</year>
<volume>15</volume>
<page-range>280-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparison of the cost-effectiveness of a computer assisted learning program with a tutored demonstration to teach intestinal motility to medical students]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leathard]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
<name>
<surname><![CDATA[Dewhurst]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Assoc. Learn. Technol]]></source>
<year>1995</year>
<volume>3</volume>
<page-range>118- 125</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Do computer simulations of laboratory practicals meet learning needs]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[IE]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends. Pharmacol. Sci]]></source>
<year>2001</year>
<volume>22</volume>
<page-range>71-4</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Alternatives to animal experimentation in biomedical education]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gruber]]></surname>
<given-names><![CDATA[FP]]></given-names>
</name>
<name>
<surname><![CDATA[Dewhurst]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[ALTEX]]></source>
<year>2004</year>
<volume>21</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>33-48</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Actividades de EURCA (European Resource Center for Alternatives in Higher Education) en el desarrollo e implantación de métodos alternativos al uso de animales en docencia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vinardell]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
</person-group>
<source><![CDATA[Edusfarm]]></source>
<year>2007</year>
<volume>2</volume>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[MeISE: Metodología de ingeniería de software educativo]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abud]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev. Int. Educ. Ing]]></source>
<year>2009</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Is it possible to meet the learning objectives of undergraduate pharmacology classes with non-animal models?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dewhurst]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[AATEX]]></source>
<year>2007</year>
<volume>14</volume>
<page-range>21-5</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neurons in action: computer simulations with NeuroLab]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moore]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Stuart]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Undergrad. Neurosc. Educ]]></source>
<year>2004</year>
<volume>2</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>6-7</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Interactive simulators to study the passive properties of the axon and the dendritic tree]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes Lazalde]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Fuchs]]></surname>
<given-names><![CDATA[OL]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev. Mex. Ing. Biomedica]]></source>
<year>2012</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>29-40</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cronin]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Mathematical aspects of Hodgkin-Huxley neural theory]]></source>
<year>1987</year>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[Cambridge University Press]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
