<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-8897</journal-id>
<journal-title><![CDATA[Hidrobiológica]]></journal-title>
<abbrev-journal-title><![CDATA[Hidrobiológica]]></abbrev-journal-title>
<issn>0188-8897</issn>
<publisher>
<publisher-name><![CDATA[Universidad Autónoma Metropolitana, División de Ciencias Biológicas y de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-88972019000300181</article-id>
<article-id pub-id-type="doi">10.24275/uam/izt/dcbs/hidro/2020v29n3/rumahlatu</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Effect of cadmium on the concentration and expression of TNF-&#945; protein in sea urchin Diadema setosum (Leske, 1778)]]></article-title>
<article-title xml:lang="es"><![CDATA[Efecto del cadmio sobre la concentración y expresión de la proteína TNF-&#945; en el erizo marino Diadema setosum (Leske, 1778)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rumahlatu]]></surname>
<given-names><![CDATA[Dominggus]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duran-Corebima]]></surname>
<given-names><![CDATA[Aloysius]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amin]]></surname>
<given-names><![CDATA[Mohamad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rohman]]></surname>
<given-names><![CDATA[Fatchur]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pattimura University Faculty of Teacher Training and Education ]]></institution>
<addr-line><![CDATA[ Ambon]]></addr-line>
<country>Indonesia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,State University of Malang Faculty of Mathematics and Science Department of Biology]]></institution>
<addr-line><![CDATA[ Malang]]></addr-line>
<country>Indonesia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>29</volume>
<numero>3</numero>
<fpage>181</fpage>
<lpage>188</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-88972019000300181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-88972019000300181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-88972019000300181&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: Cadmium (Cd) is a toxic heavy metal present in seawater, and can damage DNA, producing lipid peroxidation, and protein inactivation.  Goals: This research aimed to investigate the effect of Cd on the concentration and expression of TNF-&#945; protein in the Diadema setosum.  Methods:  This study was conducted for 4 weeks in the laboratory of Marine Conservation LIPI Ambon. Experimental Cd concentrations were 0.0, 1.0, 3.0, 6.0, 9.0, and 12.0 µg/L. The experiment was conducted in 6 tanks (100 x 60 x 70 cm3) each one with 7 individuals of D. setosum as 7 biological replicates. The examination of activation and concentration of TNF-&#945; was performed with immunohistochemical techniques as well as indirect ELISA and western blotting at the Laboratory of Medical Physiology of Brawijaya University. The data related to TNF-&#945; protein concentrations were analyzed by one way ANOVA and a Duncan test (p &lt; 0.05).  Results: The results showed that Cd treatment significantly increased the levels of TNF-&#945; protein. There is a linear relationship between Cd concentration and TNF-&#945; protein levels. The level of the TNF-&#945; protein at the concentration of 12 µg/L Cd was the highest.  Conclusions:  The results of this research on the concentration and presence of TNF-&#945; protein indicate that this approach could be implemented as a biomonitoring model of the exposure to Cd at the molecular level using D. setosum as bioindicator species in marine waters.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Antecedentes:  El cadmio (Cd) es un metal pesado tóxico presente en el agua de mar y puede dañar el ADN, produciendo peroxidación de lípidos e inactivación de proteínas.  Objetivos:  Este trabajo tuvo como objetivo investigar el efecto del Cd sobre la concentración y expresión de la proteína TNF-&#945; en Diadema setosum.  Métodos:  Este estudio se realizó durante 4 semanas en el laboratorio de Conservación Marina LIPI Ambon. Las concentraciones experimentales de Cd fueron 0.0, 1.0, 3.0, 6.0, 9.0 y 12.0 µg/L. El experimento se realizó en 6 tanques (100 x 60 x 70 cm3) cada uno con 7 individuos de D. setosum, así como 7 réplicas biológicas. El examen de activación y concentración de TNF-&#945; se realizó con técnicas inmunohistoquímicas, así como ELISA indirecto y western blot en el Laboratorio de Fisiología Médica de la Universidad Brawijaya. Los datos relacionados con las concentraciones de proteína TNF-&#945; se analizaron mediante ANOVA de una vía y una prueba de Duncan (p &lt;0,05).  Resultados:  Los resultados mostraron que el tratamiento con Cd aumentó significativamente los niveles de proteína TNF-&#945;. Existe una relación lineal entre la concentración de Cd y los niveles de proteína TNF-&#945;. El nivel de la proteína TNF-&#945; con la concentración de 12 µg/L de Cd fue el más alto.  Conclusiones:  Los resultados de esta investigación sobre la concentración y presencia de proteína TNF-&#945; indican que este enfoque podría implementarse como un modelo de biomonitoreo de la exposición al Cd a nivel molecular utilizando D. setosum como especie bioindicadora en aguas marinas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[heavy metal cadmium]]></kwd>
<kwd lng="en"><![CDATA[Diadema setosum]]></kwd>
<kwd lng="en"><![CDATA[TNF-&#945; protein]]></kwd>
<kwd lng="en"><![CDATA[biomonitoring]]></kwd>
<kwd lng="es"><![CDATA[cadmio de metales pesados]]></kwd>
<kwd lng="es"><![CDATA[Diadema setosum]]></kwd>
<kwd lng="es"><![CDATA[proteína TNF-&#945;]]></kwd>
<kwd lng="es"><![CDATA[biomonitoreo]]></kwd>
</kwd-group>
</article-meta>
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