<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-6266</journal-id>
<journal-title><![CDATA[Acta universitaria]]></journal-title>
<abbrev-journal-title><![CDATA[Acta univ]]></abbrev-journal-title>
<issn>0188-6266</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Guanajuato, Dirección de Investigación y Posgrado]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-62662025000100109</article-id>
<article-id pub-id-type="doi">10.15174/au.2025.4187</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[CellCorticalDisplastic: simulador educativo de la recuperación de la desensibilización del receptor N-metil-D-aspartato]]></article-title>
<article-title xml:lang="en"><![CDATA[CellCorticalDisplastic: educational simulator for the recovery from desensitization of N-methyl-D-aspartate receptor]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Monreal]]></surname>
<given-names><![CDATA[Marleni]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Bonilla]]></surname>
<given-names><![CDATA[María Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero Pérez]]></surname>
<given-names><![CDATA[Jessica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Lazalde]]></surname>
<given-names><![CDATA[Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernábe Loranca]]></surname>
<given-names><![CDATA[María Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Escuela de Artes Plásticas y Audiovisuales ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Facultad de Ciencias Biológicas ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Facultad de Ciencias de la Computación ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>35</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-62662025000100109&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-62662025000100109&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-62662025000100109&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El receptor N-metil-D-aspartato (NMDA) constituye un componente importante de las sinapsis excitatorias. No existen simuladores educativos que aborden la recuperación de la desensibilización del receptor NMDA. En este contexto, se ha concebido un simulador educativo orientado a la enseñanza de este proceso. Para interesar a los alumnos, se basó en registros electrofisiológicos de la recuperación de la desensibilización en tres tipos de células de la corteza de un paciente pediátrico con displasia cortical: neuronas localizadas fuera de la corteza displásica (NO-CD), neuronas de la corteza displásica aparentemente normales (CD-aparentemente normales) y neuronas citomegálicas de la corteza displásica (CD-citomegálicas). El simulador reproduce la recuperación de la desensibilización de cada una de estas células, validando los procesos modelados. El modelo matemático implementado permitió estimar teóricamente la concentración de calcio interno en los experimentos reportados. El simulador cuenta con un conjunto de lecciones que introduce al alumno en el tema y permite realizar prácticas virtuales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The receptor N-methyl-D-aspartate (NMDA) is a key component of excitatory synapses. Currently, there are no educational simulators addressing the recovery from the desensitization of the NMDA receptor. In this context, an educational simulator has been developed to facilitate the teaching of this process. To engage students, the simulator is based on electrophysiological recordings of recovery from desensitization in three types of cortical cells from a pediatric patient with cortical dysplasia: neurons located outside the dysplastic cortex (non-CD normal-appearing), neurons from the dysplastic cortex with an apparently normal morphology (CD normal-appearing), and cytomegalic neurons from the dysplastic cortex (CD cytomegalic). The simulator reproduces the recovery from desensitization for each of these cell types, validating the modeled processes. The implemented mathematical model enabled a theoretical estimation of intracellular calcium concentration based on the reported experiments. Additionally, the simulator includes a set of lessons that introduce students to the subject and allows them to perform virtual practical exercises.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Simuladores educativos]]></kwd>
<kwd lng="es"><![CDATA[receptor NMDA]]></kwd>
<kwd lng="es"><![CDATA[recuperación de la desensibilización]]></kwd>
<kwd lng="es"><![CDATA[desensibilización]]></kwd>
<kwd lng="en"><![CDATA[Educational simulators]]></kwd>
<kwd lng="en"><![CDATA[NMDA receptor]]></kwd>
<kwd lng="en"><![CDATA[recovery from desensitization]]></kwd>
<kwd lng="en"><![CDATA[desensitization]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akil]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Balice-Gordon]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Koroshetz]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Posey]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Sherer]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Sherman]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Thiels]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuroscience training for the 21st Century]]></article-title>
<source><![CDATA[Neuron]]></source>
<year>2016</year>
<volume>90</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>917-26</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Altimus]]></surname>
<given-names><![CDATA[C. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Marlin]]></surname>
<given-names><![CDATA[B. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Charalambakis]]></surname>
<given-names><![CDATA[N. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Colón-Rodriquez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Glover]]></surname>
<given-names><![CDATA[E. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Izbicki]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Lourenco]]></surname>
<given-names><![CDATA[M. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Makinson]]></surname>
<given-names><![CDATA[R. A.]]></given-names>
</name>
<name>
<surname><![CDATA[McQuail]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Obeso]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Padilla-Coreano]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Wells]]></surname>
<given-names><![CDATA[M. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The next 50 years of neuroscience]]></article-title>
<source><![CDATA[Journal of Neuroscience]]></source>
<year>2020</year>
<volume>40</volume>
<numero>21</numero>
<issue>21</issue>
<page-range>101-6</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[V. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Flores-Hernández]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Cepeda]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Starling]]></surname>
<given-names><![CDATA[A. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lobo]]></surname>
<given-names><![CDATA[M. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Vinters]]></surname>
<given-names><![CDATA[H. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[M. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mathern]]></surname>
<given-names><![CDATA[G. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue]]></article-title>
<source><![CDATA[Cerebral Cortex]]></source>
<year>2004</year>
<volume>14</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>634-46</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aneja]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Jain]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Refractory epilepsy in children]]></article-title>
<source><![CDATA[The Indian Journal of Pediatrics]]></source>
<year>2014</year>
<volume>81</volume>
<page-range>1063-72</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Av-Ron]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Byrne]]></surname>
<given-names><![CDATA[M. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Byrne]]></surname>
<given-names><![CDATA[J. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Baxter]]></surname>
<given-names><![CDATA[D. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[SNNAP: a tool for teaching neuroscience]]></article-title>
<source><![CDATA[Brains, Minds and Media]]></source>
<year>2008</year>
<volume>3</volume>
<page-range>1-11</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berkefeld]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Fakler]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Schulte]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ca2+-activated K+ channels: from protein complexes to function]]></article-title>
<source><![CDATA[Physiological Reviews]]></source>
<year>2010</year>
<volume>90</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1437-59</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bower]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Beeman]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Bower]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Beeman]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Neural Modeling with GENESIS. The Book of GENESIS]]></source>
<year>1995</year>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carnevale]]></surname>
<given-names><![CDATA[N. T.]]></given-names>
</name>
<name>
<surname><![CDATA[Hines]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
</person-group>
<source><![CDATA[The NEURON book]]></source>
<year>2006</year>
<publisher-name><![CDATA[Cambridge University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cepeda]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[V. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[M. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Salamon]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Miyata]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Vinters]]></surname>
<given-names><![CDATA[H. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Mathern]]></surname>
<given-names><![CDATA[G. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis]]></article-title>
<source><![CDATA[Epilepsy &amp; Behavior]]></source>
<year>2006</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>219-35</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cepeda]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[V. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Yamazaki]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Uzgil]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Vinters]]></surname>
<given-names><![CDATA[H. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[M. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mathern]]></surname>
<given-names><![CDATA[G. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia]]></article-title>
<source><![CDATA[Epilepsia]]></source>
<year>2007</year>
<volume>48</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>79-85</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cepeda]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Hurst]]></surname>
<given-names><![CDATA[R. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Flores-Hernández]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández-Echeagaray]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Klapstein]]></surname>
<given-names><![CDATA[G. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Boylan]]></surname>
<given-names><![CDATA[M. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Calvert]]></surname>
<given-names><![CDATA[C. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Jocoy]]></surname>
<given-names><![CDATA[E. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[O. K.]]></given-names>
</name>
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[V. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Vinters]]></surname>
<given-names><![CDATA[H. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Ariano]]></surname>
<given-names><![CDATA[M. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[M. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mathern]]></surname>
<given-names><![CDATA[G. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia]]></article-title>
<source><![CDATA[Journal of Neuroscience Research]]></source>
<year>2003</year>
<volume>72</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>472-86</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Crino]]></surname>
<given-names><![CDATA[P. B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Focal cortical dysplasia]]></article-title>
<source><![CDATA[Seminars in Neurology]]></source>
<year>2015</year>
<volume>35</volume>
<numero>03</numero>
<issue>03</issue>
<page-range>201-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Diwakar]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Parasuram]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Medini]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Raman]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Nedungadi]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Wiertelak]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Srivastava]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Achuthan]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Nair]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Complementing neurophysiology education for developing countries via cost-effective virtual labs: case studies and classroom scenarios]]></article-title>
<source><![CDATA[Journal of Undergraduate Neuroscience Education]]></source>
<year>2014</year>
<volume>12</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>130-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Markram]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A brief history of simulation neuroscience]]></article-title>
<source><![CDATA[Frontiers in Neuroinformatics]]></source>
<year>2019</year>
<volume>13</volume>
<page-range>1-28</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Guzmán]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La nueva Licenciatura en Neurociencias de la UNAM: lecciones aprendidas]]></article-title>
<source><![CDATA[Investigación en Educación Médica]]></source>
<year>2019</year>
<volume>8</volume>
<numero>29</numero>
<issue>29</issue>
<page-range>104-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gerstner]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Sprekeler]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Deco]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Theory and simulation in neuroscience]]></article-title>
<source><![CDATA[Science]]></source>
<year>2012</year>
<volume>338</volume>
<numero>6103</numero>
<issue>6103</issue>
<page-range>60-5</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldman]]></surname>
<given-names><![CDATA[M. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Fee]]></surname>
<given-names><![CDATA[M. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Computational training for the next generation of neuroscientists]]></article-title>
<source><![CDATA[Current Opinion in Neurobiology]]></source>
<year>2017</year>
<volume>46</volume>
<page-range>25-30</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Camargo]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Yeboah]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Digan]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Niu]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Reiling]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Soler-Llavina]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Weihofen]]></surname>
<given-names><![CDATA[W. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Shanker]]></surname>
<given-names><![CDATA[Y. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Stams]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Bill]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine]]></article-title>
<source><![CDATA[Scientific Reports]]></source>
<year>2017</year>
<volume>7</volume>
<numero>11608</numero>
<issue>11608</issue>
<page-range>1-13</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Carrillo]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Campillo]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Mendiola]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Investigación traslacional en ciencias de la salud: implicaciones educativas y retos]]></article-title>
<source><![CDATA[Investigación en Educación Médica]]></source>
<year>2018</year>
<volume>7</volume>
<numero>28</numero>
<issue>28</issue>
<page-range>85-97</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herta]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Dorfer]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Surgical treatment for refractory epilepsy]]></article-title>
<source><![CDATA[Journal of Neurosurgical Sciences]]></source>
<year>2019</year>
<volume>63</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>50-60</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Horrigan]]></surname>
<given-names><![CDATA[L. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tackling the threshold concepts in physiology: What is the role of the laboratory class?]]></article-title>
<source><![CDATA[Advances in Physiology Education]]></source>
<year>2018</year>
<volume>42</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>507-15</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Iacobucci]]></surname>
<given-names><![CDATA[G. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Popescu]]></surname>
<given-names><![CDATA[G. K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resident calmodulin primes NMDA receptors for Ca2+-dependent inactivation]]></article-title>
<source><![CDATA[Biophysical Journal]]></source>
<year>2017</year>
<volume>113</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2236-48</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Inglebert]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Debanne]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calcium and spike timing-dependent plasticity]]></article-title>
<source><![CDATA[Frontiers in Cellular Neurophysiology]]></source>
<year>2021</year>
<volume>15</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jahr]]></surname>
<given-names><![CDATA[C. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Stevens]]></surname>
<given-names><![CDATA[C. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A quantitative description of NMDA receptor-channel kinetic behavior]]></article-title>
<source><![CDATA[The Journal of Neuroscience]]></source>
<year>1990</year>
<volume>10</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1830-7</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jahr]]></surname>
<given-names><![CDATA[C. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Stevens]]></surname>
<given-names><![CDATA[C. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics]]></article-title>
<source><![CDATA[The Journal of Neuroscience]]></source>
<year>1990</year>
<volume>10</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>3178-82</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lorenz]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Egelhaaf]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Curricular integration of simulations in neuroscience]]></article-title>
<source><![CDATA[Brains, Minds &amp; Media]]></source>
<year>2008</year>
<volume>3</volume>
<page-range>1-20</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McDougal]]></surname>
<given-names><![CDATA[R. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bulanova]]></surname>
<given-names><![CDATA[A. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lytton]]></surname>
<given-names><![CDATA[W. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reproducibility in computational neuroscience models and simulations]]></article-title>
<source><![CDATA[IEEE Transactions on Biomedical Engineering]]></source>
<year>2016</year>
<volume>63</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2021-35</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meldolesi]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rapidly exchanging Ca2+ stores in neurons: molecular, structural and functional properties]]></article-title>
<source><![CDATA[Progress in Neurobiology]]></source>
<year>2001</year>
<volume>65</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>309-38</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mohsin]]></surname>
<given-names><![CDATA[S. N.]]></given-names>
</name>
<name>
<surname><![CDATA[Grezenko]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Eshete]]></surname>
<given-names><![CDATA[F. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Shrestha]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kamran]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Affaf]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jama]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gasim]]></surname>
<given-names><![CDATA[R. W.]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[D. Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Yadav]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Arif]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[K. C.]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Khaliq]]></surname>
<given-names><![CDATA[A. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bridging development and disruption: comprehensive insights into focal cortical dysplasia and epileptic management]]></article-title>
<source><![CDATA[Cureus]]></source>
<year>2023</year>
<volume>15</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oprisan]]></surname>
<given-names><![CDATA[S. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interdisciplinary curriculum for computational neuroscience at primarily undergraduate institutions]]></article-title>
<source><![CDATA[Journal of Computational Science]]></source>
<year>2022</year>
<volume>61</volume>
<page-range>1-21</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes-Monreal]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Quintero-Pérez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Bonilla]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes-Lazalde]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Flores-Hernández]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lab-NMDAR: simuladores de la electrofisiología básica del receptor NMDA]]></article-title>
<source><![CDATA[Acta Universitaria]]></source>
<year>2022</year>
<volume>32</volume>
<page-range>1-23</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes-Monreal]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Quintero-Pérez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Bonilla]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Escalera]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes-Lazalde]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Theoretical calculation of NMDA receptor desensitization and intracellular calcium determination through simulation]]></source>
<year>2024</year>
</nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sibarov]]></surname>
<given-names><![CDATA[D. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Antonov]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calcium-dependent desensitization of NMDA receptors]]></article-title>
<source><![CDATA[Biochemistry (Moscow)]]></source>
<year>2018</year>
<volume>83</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1173-83</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Szydlowska]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Tymianski]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calcium, ischemia and excitotoxicity]]></article-title>
<source><![CDATA[Cell Calcium]]></source>
<year>2010</year>
<volume>47</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>122-9</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van Vugt]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[van Kerkoerle]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Vartak]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Roelfsema]]></surname>
<given-names><![CDATA[P. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The contribution of AMPA and NMDA receptors to persistent firing in the dorsolateral prefrontal cortex in working memory]]></article-title>
<source><![CDATA[Journal of Neuroscience]]></source>
<year>2020</year>
<volume>40</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2458-70</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vyklický]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calcium&#8208;mediated modulation of N&#8208;methyl&#8208;D&#8208;aspartate (NMDA) responses in cultured rat hippocampal neurones]]></article-title>
<source><![CDATA[The Journal of Physiology]]></source>
<year>1993</year>
<volume>470</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>575-600</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
