<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-6266</journal-id>
<journal-title><![CDATA[Acta universitaria]]></journal-title>
<abbrev-journal-title><![CDATA[Acta univ]]></abbrev-journal-title>
<issn>0188-6266</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Guanajuato, Dirección de Investigación y Posgrado]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-62662021000100129</article-id>
<article-id pub-id-type="doi">10.15174/au.2021.2923</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[High fructose corn syrup supplementation progressively increased serum adenosine and inosine: Inosine raising blood pressure and heart rate in rats]]></article-title>
<article-title xml:lang="es"><![CDATA[La suplementación con jarabe de maíz de alta fructosa incrementó progresivamente la adenosina e inosina en suero y la inosina aumentó la presión arterial y la frecuencia cardiaca en ratas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guinzberg]]></surname>
<given-names><![CDATA[Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallardo-Ortíz]]></surname>
<given-names><![CDATA[Itzell A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Guerrero]]></surname>
<given-names><![CDATA[J. Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piña]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villalobos-Molina]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Departamento de Bioquímica]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[ Estado de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Politécnico Nacional Centro de Investigación y de Estudios Avanzados Departamento de Farmacobiología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>31</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-62662021000100129&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-62662021000100129&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-62662021000100129&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract High fructose corn syrup (HFCS) over-consumption underlies the obesity worldwide epidemics. Hepatic fructose metabolism includes fructolysis, lipogenesis, and purines degradation to uric acid. The aim of this study was to evaluate HFCS long-term effects on serum and hepatic adenosine (Ado) and inosine (Ino), as well as in vivo Ino effects on cardiovascular function. Fed male Wistar rats were subjected to 30% HFCS-enriched drinking water for five months (n = 15); every month, nucleosides were determined in serum and in isolated liver perfusate. Three months-old male naive Wistar rats were pithed and cannulated to record blood pressure and heart rate after Ino administration (n = 3). Rats consuming HFCS increased both Ado and Ino progressively in serum and livers&#8217; perfusate; Ino increased cardiovascular function. The progressive Ado and Ino hepatic release by fructose-enriched diet suggests their contribution to raise glycemia through their gluconeogenic activation, and a higher serum Ino concentration might be related to increase in arterial blood pressure.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El sobre consumo de jarabe de maíz de alta fructosa (HFCS) subyace a la epidemia mundial de obesidad. El metabolismo hepático de fructosa incluye fructolisis, lipogénesis y degradación de purinas a ácido úrico. El objetivo del estudio fue evaluar los efectos a largo plazo de HFCS sobre adenosina (Ado) e inosina (Ino) en suero e hígado, así como los efectos in vivo de Ino sobre la función cardiovascular. Se usaron ratas Wistar macho (n = 15) alimentadas que bebieron agua adicionada con 30% HFCS durante cinco meses; cada mes, se determinaron los nucleósidos en suero y en perfusado hepático. Se descerebraron y desmedularon ratas Wistar macho no tratadas de 3 meses (n = 3) y se canularon para registrar la presión arterial y la frecuencia cardiaca post-administración de Ino. Las ratas con HFCS aumentaron Ado e Ino progresivamente en suero y en perfusado hepático; Ino incrementó la función cardiovascular. La liberación hepática de Ado e Ino por dieta enriquecida con fructosa sugiere su contribución para aumentar la glucemia por activación gluconeogénica, y el aumento sérico de Ino puede estar relacionado con hipertensión arterial.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[High fructose corn syrup]]></kwd>
<kwd lng="en"><![CDATA[adenosine]]></kwd>
<kwd lng="en"><![CDATA[inosine]]></kwd>
<kwd lng="en"><![CDATA[rat liver]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular function]]></kwd>
<kwd lng="es"><![CDATA[HFCS]]></kwd>
<kwd lng="es"><![CDATA[adenosina]]></kwd>
<kwd lng="es"><![CDATA[inosina]]></kwd>
<kwd lng="es"><![CDATA[hígado de rata]]></kwd>
<kwd lng="es"><![CDATA[función cardiovascular]]></kwd>
</kwd-group>
</article-meta>
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