<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-4999</journal-id>
<journal-title><![CDATA[Revista internacional de contaminación ambiental]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Int. Contam. Ambient]]></abbrev-journal-title>
<issn>0188-4999</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Instituto de Ciencias de la Atmósfera y Cambio Climático]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-49992022000100128</article-id>
<article-id pub-id-type="doi">10.20937/rica.54342</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inhibición in vitro de la metanogénesis ruminal de una dieta alta en grano con lovastatina]]></article-title>
<article-title xml:lang="en"><![CDATA[In vitro inhibition of rumen methanogenesis of a high-grain diet using lovastatin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ábrego-García]]></surname>
<given-names><![CDATA[Amaury]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Poggi-Varaldo]]></surname>
<given-names><![CDATA[Héctor Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Robles-González]]></surname>
<given-names><![CDATA[Vania Shuhua]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ríos-Leal]]></surname>
<given-names><![CDATA[Elvira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ponce-Noyola]]></surname>
<given-names><![CDATA[Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calva-Calva]]></surname>
<given-names><![CDATA[Graciano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estrada-Bárcenas]]></surname>
<given-names><![CDATA[Daniel Alfonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza-Vargas]]></surname>
<given-names><![CDATA[Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Politécnico Nacional Departamento de Biotecnología y Bioingeniería ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Tecnológica de la Mixteca Instituto de Hidrología ]]></institution>
<addr-line><![CDATA[Huajuapan de León Oaxaca]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Colección Nacional de Cepas Microbianas y Cultivos Celulares  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Medicina Genómica Unidad de Secuenciación e Identificación de Polimorfismos ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>38</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-49992022000100128&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-49992022000100128&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-49992022000100128&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Uno de los mayores impactos ambientales de la ganadería es la emisión de metano entérico, un potente gas de efecto invernadero. En este contexto, se han evaluado algunos compuestos antimetanogénicos tales como la lovastatina (LOV), un inhibidor de la hidroximetilglutaril-CoA reductasa, enzima clave para la síntesis de membrana en arqueas metanogénicas. Esta podría ser una opción para mitigar las emisiones de metano ruminal. Sin embargo, los experimentos in vitro son escasos y no existe un criterio general sobre la mitigación de metano con LOV en estas condiciones. Por lo tanto, el objetivo de esta investigación fue evaluar el efecto in vitro de la LOV sobre la metanogénesis y características de la fermentación ruminal, así como comparar los resultados con aquellos de la monensina (MON) y el ácido bromoetano sulfónico (BES). Se realizó una prueba in vitro en lote. Se utilizó una ración alta en grano, fluido ruminal de bovinos y tres inhibidores metanogénicos. El diseño experimental fue completamente al azar con tres tratamientos (LOV, MON, BES) y un testigo sin inhibidor. En este trabajo la LOV mostró efectos alentadores sobre la mitigación de la metanogénesis en la fermentación ruminal (43.56 %) sin afectar la producción total y perfil de AGV. Sin embargo, la dosis para obtener este resultado fue mayor en comparación con las de los otros tratamientos. La MON fue la más efectiva con relación a la concentración/inhibición de la metanogénesis, seguida del BES. Ambos tratamientos presentaron cambios en el perfil de AGV.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT One of the greatest environmental impacts from livestock is caused by enteric methane emissions, a powerful greenhouse gas. In this context, some anti-methanogenic compounds have been evaluated, such as lovastatin (LOV), which is a hydroxymethylglutaryl-CoA reductase inhibitor, a key enzyme for membrane synthesis of methanogenic archaea. This could be an option to mitigate methane emissions from ruminants. However, there are few in vitro studies and there is no general agreement about the methane mitigation by LOV under these conditions. Thus, the objective of this work was to evaluate the effect of LOV on in vitro methanogenesis and fermentation characteristics in comparison with monensin (MON) and bromoethane sulfonic acid (BES). An in vitro batch incubation was carried out using a high-grain diet and bovine rumen fluid. The experimental design was completely randomized with three treatments, LOV, MON, BES, and a control with no inhibitor. The results demonstrated a favorable effect of LOV on rumen fermentation pattern in terms of methane mitigation (43.56 % inhibition) without affecting the volatile fatty acids (VFA) profile. However, the dose of LOV to obtain this result was very high compared to the doses used in the other treatments. MON was the most effective treatment based on the concentration/inhibition of methanogenesis, followed by the BES; although, both compounds were associated to changes in the VFA profile.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácido bromoetano sulfónico]]></kwd>
<kwd lng="es"><![CDATA[metano]]></kwd>
<kwd lng="es"><![CDATA[monensina]]></kwd>
<kwd lng="es"><![CDATA[rumen]]></kwd>
<kwd lng="en"><![CDATA[bromoethane sulfonic acid]]></kwd>
<kwd lng="en"><![CDATA[methane]]></kwd>
<kwd lng="en"><![CDATA[monensin]]></kwd>
<kwd lng="en"><![CDATA[rumen]]></kwd>
</kwd-group>
</article-meta>
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