<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2023000200195</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2023.2.83239</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diversidad y bioactividad de análogos semisintéticos de cannabidiol]]></article-title>
<article-title xml:lang="en"><![CDATA[Diversity and bioactivity of semisynthetic cannabidiol analogs]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Musso]]></surname>
<given-names><![CDATA[Florencia Antonella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional del Sur Instituto de Química del Sur Departamento de Química]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>34</volume>
<numero>2</numero>
<fpage>195</fpage>
<lpage>211</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2023000200195&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2023000200195&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2023000200195&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La especie vegetal Cannabis sativa (Cannabaceae) posee importantes propiedades medicinales gracias a los componentes bioactivos que posee. El fitoestrógeno CBD se puede encontrar en la planta y debido a las características terapéuticas y estructurales de la molécula, lo convierte en un interesante andamio susceptible a numerosas modificaciones sintéticas, con el fin de mejorar su eficacia y potencia terapéutica. Este trabajo proporciona información sobre los distintos análogos sintéticos de CBD descubiertos en los últimos años (2010 - 2021). La búsqueda bibliográfica se realizó en distintas bases de datos, con distintas palabras clave. Dicha búsqueda se limitó a los años 2010 - 2021, y se consideraron revisiones, micro revisiones y meta-análisis de mayor impacto. Se recopilaron alrededor de 40 nuevos análogos sintéticos de CBD y fueron clasificados según el blanco estructural modificado. Estos compuestos poseen una importante bioactividad e incluso, muchos conservan la actividad de su precursor. Sin embargo, en muchos casos, el conocimiento de su mecanismo de acción aún se encuentra en estudio por lo que se necesitan numerosas investigaciones farmacológicas y medicinales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The plant species Cannabis sativa (Cannabaceae) has important medicinal properties due to its bioactive components. The CBD phytoestrogen can be found in the plant and, due to the therapeutic and structural characteristics of the molecule, makes it an interesting scaffold susceptible to numerous synthetic modifications, in order to improve its efficacy and therapeutic potency. This work provides information on the different synthetic analogues of CBD discovered in recent years (2010 - 2021). The bibliographic search was carried out in different databases, with different keywords. This search was limited to the years 2010 - 2021, and reviews, micro-reviews and meta-analyses with the greatest impact were considered. About 40 new synthetic CBD analogs were collected and classified according to the modified structural target. These compounds have significant bioactivity and many even retain the activity of their precursor. However, in many cases the knowledge of its mechanism of action is still under study, which is why numerous pharmacological and medicinal investigations are needed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cannabis]]></kwd>
<kwd lng="es"><![CDATA[fitocannabinoides]]></kwd>
<kwd lng="es"><![CDATA[cannabidiol]]></kwd>
<kwd lng="es"><![CDATA[derivados sintéticos]]></kwd>
<kwd lng="es"><![CDATA[química medicinal]]></kwd>
<kwd lng="en"><![CDATA[Cannabis]]></kwd>
<kwd lng="en"><![CDATA[phytocannabinoids]]></kwd>
<kwd lng="en"><![CDATA[cannabidiol]]></kwd>
<kwd lng="en"><![CDATA[synthetic derivatives]]></kwd>
<kwd lng="en"><![CDATA[medicinal chemistry]]></kwd>
</kwd-group>
</article-meta>
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